Neuroprotective effects of vitamin <scp>D</scp> in an <scp>Alzheimer's</scp> disease rat model: Improvement of mitochondrial dysfunction via calcium/calmodulin‐dependent protein kinase kinase 2 activation of <scp>Sirtuin1</scp> phosphorylation

Mohanad, Marwa; Mohamed, Shimaa K.; Aboulhoda, Basma E.; Ahmed, Maha A. E.

doi:10.1002/biof.2013

Cited by 6 publications

(1 citation statement)

References 88 publications

(187 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The regulation of mitochondrial function has been seen as helpful in reversing age-related hypertension in young male mice [ 85 ]. Again, due to the known role of mitochondria in neurodegeneration and Alzheimer’s disease in particular, Mohanad et al found that VitD was able to improve the oxidative stress and mitochondrial function in a preclinical model of induced AD, through calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)-mediated phosphorylation of Sirtuin1 (SIRT1) [ 86 ].…”

Section: Vitamin D and Its Potential Impact On The Biological Hallmar...mentioning

confidence: 99%

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Ruggiero,

Tafaro,

Cianferotti

et al. 2024

Nutrients

View full text Add to dashboard Cite

Aging is the result of several complex and multifactorial processes, where several agents contribute to an increased intrinsic vulnerability and susceptibility to age-related diseases. The hallmarks of aging are a set of biological mechanisms that are finely regulated and strictly interconnected, initiating or contributing to biological changes and anticipating several age-related diseases. The complex network of cellular and intercellular connections between the hallmarks might represent a possible target for the research of agents with pleiotropic effects. Vitamin D (VitD) is known to have a positive impact not only on muscle and bone health but also on several extra-skeletal districts, due to the widespread presence of Vitamin D Receptors (VDRs). VitD and VDR could be molecules potentially targeting the hallmarks of the aging network. To date, evidence about the potential effects of VitD on the hallmarks of aging is scarce in humans and mainly based on preclinical models. Although underpowered and heterogeneous, in-human studies seem to confirm the modulatory effect of VitD on some hallmarks of aging and diseases. However, more investigations are needed to clarify the pleiotropic effects of VitD and its impact on the hallmark of aging, hopefully highlighting the courses for translational applications and potential clinical conclusions.

show abstract

Section: Vitamin D and Its Potential Impact On The Biological Hallmar...mentioning

confidence: 99%

Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth

Ruggiero,

Tafaro,

Cianferotti

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

Are the promnestic effects of neurokinin 3 receptor mediated by hippocampal neurogenesis in a Aβ‐induced rat model of Alzheimer's disease?

Koca,

Gormus,

Solak

et al. 2024

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Alzheimer's disease (AD) is an age‐related neurodegenerative disorder characterised by cognitive dysfunction, memory loss and mood changes. Hippocampal neurogenesis has been suggested to play a role in learning and memory. Neurokinin 3 receptor (NK3R) has been shown to be prevalent in the hippocampus region. The aim of the project was to investigate the role of hippocampal neurogenesis in the promnestic effects of NK3R agonist administration in an amyloid beta‐induced AD rat model. Wistar albino rats were divided into control, Alzheimer, NK3R agonist and Alzheimer + NK3R agonist groups. The open field (OF) test and Morris water maze (MWM) test were performed for locomotor activity and memory analysis. Peptide gene expression levels (Nestin, DCX, Neuritin, MASH1, Neun, BDNF) were analysed by quantitative reverse transcription polymerase chain reaction (RT‐PCR). In the OF test, the group–time relationship was found to be statistically different in the parameters of distance travelled and percentage of movement (p < 0.05). In MWM, the time to reach the platform and the time spent in the target quadrant were statistically significant between the groups (p < 0.05). Statistically significant differences were observed in gene expression levels (Nestin, DCX, Neuritin, MASH1) in the hippocampal tissue of rats between the groups (p < 0.05). NK3 receptor agonism favourably affected hippocampal neurogenesis in AD model rats. It was concluded that NK3 receptor agonism in the hippocampus, which is the first affected region in the physiopathology of AD, may be effective in both the formation of neural precursor cells and the reduction of neuronal degeneration. The positive effect of NK3R on cognitive functions may be mediated by hippocampal neurogenesis.

show abstract