Neuroprotective Effects of Traditional Chinese Medicine Monomers for Spinal Cord Injury in Animal Models:A Systematic Review and Network Meta-Analysis

Abstract

Review question / Objective: 2.1.1 Participants -In rodents (mainly rats), the pathophysiology during SCI is similar to humans, and they are also less expensive and more standardized, making them the most commonly used SCI animal model. Therefore, we included rat models as the experimental animal model without restricting the rat strain. The injury method of SCI used contusion and compression injury. 2.1.2 Interventions -TCM monomers (CUR, TMP, RSV, GS, TIIA). 2.1.3 Control -(1) Positive control: contrasts between different TCM monomers. (2) Negative control: normal saline, vehicle, blank, PBS, DMSO. 2.1.4 Outcome-In rats with SCI, the Basso-Beattie-Bresnahan (BBB) Locomotor Rating Scale score measures motor abilities, which ranges from 0 to 21 (spanning from complete flaccid paraplegia to normal function), and can reflect the recovery of motor function sensitively. 2.1.5 Type of Study -Control studies were included. INPLASY registration number: This protocol was registered with the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) on 22 January 2023 and was last updated on 22 January 2023 (registration number INPLASY202310070).