Neuroprotective effects of three different sizes nanochelating based nano complexes in MPP(+) induced neurotoxicity

Maghsoudi, Amirhossein; Fakharzadeh, Saideh; Hafizi, Maryam; Abbasi, Maryam; Kohram, Fatemeh; Sardab, Shima; Tahzibi, Abbas; Kalanaky, Somayeh; Nazaran, Mohammad Hassan

doi:10.1007/s10495-014-1069-x

Cited by 14 publications

(8 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, BCc1 has had no adverse effects on hemoglobin and red blood cell levels. In addition, BCc1 like previous nanochelation-based structures, Msc1, Pac, Pas, and Paf) 10 , 11 has protected cells against H 2 O 2 -mediated oxidative stress, and also IR spectrum analysis has clearly demonstrated that BCc1 is an organic-hydrocarbon structure. These characters positively affect the nanocomplex biocompatibility.…”

Section: Discussionmentioning

confidence: 70%

See 1 more Smart Citation

BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo

Kalanaky

Hafizi

Fakharzadeh³

et al. 2015

DDDT

Self Cite

View full text Add to dashboard Cite

PurposeIn spite of all the efforts and researches on anticancer therapeutics, an absolute treatment is still a myth. Therefore, it is necessary to utilize novel technologies in order to synthesize smart multifunctional structures. In this study, for the first time, we have evaluated the anticancer effects of BCc1 nanocomplex by vitro and in vivo studies, which is designed based on the novel nanochelating technology.MethodsHuman breast adenocarcinoma cell line (MCF-7) and mouse embryonic fibroblasts were used for the in vitro study. Antioxidant potential, cell toxicity, apoptosis induction, and CD44 and CD24 protein expression were evaluated after treatment of cells with different concentrations of BCc1 nanocomplex. For the in vivo study, mammary tumor-bearing female Balb/c mice were treated with different doses of BCc1 and their effects on tumor growth rate and survival were evaluated.ResultsBCc1 decreased CD44 protein expression and increased CD24 protein expression. It induced MCF-7 cell apoptosis but at the same concentrations did not have negative effects on mouse embryonic fibroblasts viability and protected them against oxidative stress. Treatment with nanocomplex increased survival and reduced the tumor size growth in breast cancer-bearing balb/c mice.ConclusionThese results demonstrate that BCc1 has the capacity to be assessed as a new anticancer agent in complementary studies.

show abstract

Section: Discussionmentioning

confidence: 70%

“… 10 Also Pac, Pas, and Paf nanocomplexes showed neuroprotective effects in the cellular model of Parkinson’s disease. 11 …”

Section: Introductionmentioning

confidence: 99%

BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo

Kalanaky

Hafizi

Fakharzadeh³

et al. 2015

DDDT

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the previous studies, it was revealed that nanochelating-based structures could protect cell viability against oxidative stress. 13,39,40 Numerous studies have reported pivotal role of iron in diabetes and also its complications. Free iron can make a vicious cycle, which progresses more oxidative stress and more inflammation.…”

Section: Discussionmentioning

confidence: 99%

<p>DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats</p>

Fakharzadeh

Kalanaky²,

Hafizi³

et al. 2019

IJN

Self Cite

View full text Add to dashboard Cite

Aims: Despite daily increase in diabetic patients in the world, currently approved medications for this disease, at best, only reduce its progression speed. Using novel technologies is a solution for synthetizing more efficient medicines. In the present study, we evaluated anti-diabetic effects of DIBc, a nano metal-organic framework, which is synthetized based on nanochelating technology. Methods: High-fat diet and streptozotocin-induced diabetic rats were treated by DIBc or metformin for 6 weeks. Results: DIBc decreased plasma glucose, triglyceride, cholesterol, high-density lipoprotein, and low-density lipoprotein compared with diabetic and metformin groups. In DIBc-treated rats, significant homeostasis model assessment of insulin resistance index, malondialdehyde, and tumor necrosis factor-α decrease was observed. H&E staining showed increased islet number and area in DIBc-treated rats compared with diabetic controls. Conclusion: The results showed anti-diabetic effects of nanochelating-based framework. So DIBc, as a nano structure, has the capacity to be evaluated in future studies as a novel antidiabetic agent.

show abstract

“…Recently nanochelating technology [ 15 ] synthetized and introduced novel nano complexes based on a self- assembly method [ 16 , 17 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Nanochelating based nanocomplex, GFc7, improves quality and quantity of human mesenchymal stem cells during in vitro expansion

et al. 2015

Self Cite

View full text Add to dashboard Cite

IntroductionHuman mesenchymal stem cells (hMSCs) have been approved for therapeutic applications. Despite the advances in this field, in vitro approaches are still required to improve the essential indices that would pave the way to a bright horizon for an efficient transplantation in the future. Nanotechnology could help to improve these approaches. Studies signified the important role of iron in stem cell metabolism and efficiency of copper chelation application for stem cell expansion MethodsFor the first time, based on novel Nanochelating technology, we design an iron containing copper chelator nano complex, GFc7 and examined on hMSCs during in vitro expansion. In this study, the hMSCs were isolated, characterized and expanded in vitro in two media (with or without GFc7). Then proliferation, cell viability, cell cycle analysis, surface markers, HLADR, pluripotency genes expression, homing and antioxidative defense at genes and protein expression were investigated. Also we analyzed the spontaneous differentiation and examined osteogenic and lipogenic differentiation. ResultsGFc7 affected the expression of key genes, improving both the stemness and fitness of the cells in a precise and balanced manner. We observed significant increases in cell proliferation, enhanced expression of pluripotency genes and homing markers, improved antioxidative defense, repression of genes involved in spontaneous differentiation and exposing the hMSCs to differentiation medium indicated that pretreatment with GFc7 increased the quality and rate of differentiation.ConclusionsThus, GFc7 appears to be a potential new supplement for cell culture medium for increasing the efficiency of transplantation.

show abstract

Neuroprotective effects of three different sizes nanochelating based nano complexes in MPP(+) induced neurotoxicity

Cited by 14 publications

References 46 publications

BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo

BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo

<p>DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats</p>

Nanochelating based nanocomplex, GFc7, improves quality and quantity of human mesenchymal stem cells during in vitro expansion

Contact Info

Product

Resources

About