Neuroprotective Effects of Salidroside on Cerebral Ischemia/Reperfusion-Induced Behavioral Impairment Involves the Dopaminergic System

Zhong, Zhaodong; Han, Jing; Zhang, Jizhou; Xiao, Qing; Chen, Jingyan; Zhang, Kai; Hu, Juan; Chen, Lidian

doi:10.3389/fphar.2019.01433

Cited by 35 publications

(38 citation statements)

References 70 publications

(83 reference statements)

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“…PI3K/Akt, p53, cyclin D1, caspase 3, bad, p55γ, BDNF, TrkB, GSK3β, CREB, claudin-5, NF-κB, HIF-1α (Hu et al, 2012;Song et al, 2012;Zhang et al, 2012;Chai et al, 2013;Zhang et al, 2016b; ( Chang et al, 2015;Chang et al, 2007;Ding et al, 2019;Xu et al, 2017;Yan et al, 2015;Yu, P. et al, 2017;Yu et al, 2016;Zhou et al, 2019) Daurisoline 5, 10, 20 mg/kg Cyt-C, Caspase 3, Caspase 9, SOD, MDA, GSH-Px (Li and Gong 2004;Yang et al, 2009 (Huang et al, 2018;Li et al, 2015;Lu et al, 2018;Xie, C. J. et al, 2018;Xu, N. et al, 2019) (Continued on following page) (Candelario-Jalil et al, 2007;Simao et al, 2012b;Wei et al, 2015;He et al, 2017;Koronowski et al, 2017;Yang et al, 2018b) Ellagic acid 10-100 mg/kg Bax, bcl 2, cyt C, caspase 3, PI3K/Akt, NOS, MDA, wnt/β-catenin, ZO-1, AQP 4, MMP-9 (Kaihua and Jiyu 2020;Liu, Z. B. et al, 2017;Nejad et al, 2015;Wang, F. et al, 2019) Glycoside Liu et al, 2018;Wei et al, 2017;Zhang X. et al, 2019;Zhong et al, 2019;Zuo et al, 2018) Iridoid glycoside Geniposide 5, 10, 20 mg/kg LDH, TNF-α, IL-1β, IL-6, IL-8, IL-18, NLRP3, ASC, caspase-1, raf/mek1/2/ erk1/2, MCP-1, ZO-1, occludin, Claudin-5, β-catenin, PI3K/Akt, Bcl-2/Bax, AchE, NOS, MDA, SOD (Fu et al, 2020;…”

Section: Discussionmentioning

confidence: 99%

“…Many recent reports and reviews have highlighted that salidroside may exert anti-inflammatory, neuroprotective effects and improve cognitive function ( Li, M. et al, 2018 ; Xu, N. et al, 2019 ). Salidroside may involve the modulation of monoamine metabolism in the striatum and substantia nigra pars compacta (SNpc), which may be related to the function of the dopaminergic system in the cerebral I/R brain ( Zhong et al, 2019 ). Many studies reported salidroside protected against cerebral I/R injury via PI3K/Akt pathway, accompanying with Nrf2/NF-κB pathway ( Wei et al, 2017 ; Zhang, Y. et al, 2018 ; Zhang, J. et al, 2019 ; Zuo et al, 2018 ).…”

Section: Methodsmentioning

confidence: 99%

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Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review

Xie

et al. 2021

Front. Pharmacol.

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Natural products have a significant role in the prevention of disease and boosting of health in humans and animals. Stroke is a disease with high prevalence and incidence, the pathogenesis is a complex cascade reaction. In recent years, it’s reported that a vast number of natural products have demonstrated beneficial effects on stroke worldwide. Natural products have been discovered to modulate activities with multiple targets and signaling pathways to exert neuroprotection via direct or indirect effects on enzymes, such as kinases, regulatory receptors, and proteins. This review provides a comprehensive summary of the established pharmacological effects and multiple target mechanisms of natural products for cerebral ischemic injury in vitro and in vivo preclinical models, and their potential neuro-therapeutic applications. In addition, the biological activity of natural products is closely related to their structure, and the structure-activity relationship of most natural products in neuroprotection is lacking, which should be further explored in future. Overall, we stress on natural products for their role in neuroprotection, and this wide band of pharmacological or biological activities has made them suitable candidates for the treatment of stroke.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review

Xie

et al. 2021

Front. Pharmacol.

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“…After going through the remaining full-text articles, 120 articles were excluded for at least one of following reasons: 1) the article was not a research about ischemic stroke; 2) not an in vivo study; 3) the intervention was a combination of RRC with potential effect on ischemic stroke; 4) the study did not access the effects of RRC on the animal model of ischemic stroke; 5) no control group. Finally, 15 eligible studies (Chen et al, 2009; Shi et al, 2012;Chen et al, 2014;Yu et al, 2014;Han et al, 2015;Atochin et al, 2016;Chen et al, 2016;Liu et al, 2018;Zhang et al, 2018;Zuo et al, 2018;Zhong et al, 2019;Li et al, 2020;Zhang et al, 2020;Dong et al, 2021) involving 345 animals were identified (Figure 1).…”

Section: Study Inclusionmentioning

confidence: 99%

“…In traditional Russian (Siberian) folk medicine, Rhodiola rosea L. has been used as an adaptogenic medicinal product for a long time (Ioset et al, 2011), and the plant is useful for increasing mental and physical capacities (Panossian., et al, 2021). Modern pharmacological researchies have revealed multiple bioactivities from Rhodiola rosea L. and its components (RRC) such as anti-oxidative (Zhang et al, 2007), anti-inflammation (Pu et al, 2020), anti-fatigue (Shevtsov et al, 2003), immune enhancement (Tao et al, 2019) and neuroprotective effects (Yu et al, 2008), for treatment of Alzheimer's disease, cardiovascular disease, cognitive dysfunctions, cancer, and stroke (Zhong et al, 2019;Fan et al, 2020). Salidroside, rhodiosin, p-tryosol, pyridrde, rosavin, rhodionin (Zhang et al, 2006) and ferulic acid eicosyl ester (Michels et al, 2018) are the main bioactive compounds in the Rhodiola species.…”

Section: Introductionmentioning

confidence: 99%

Preclinical Evidence and Possible Mechanisms of Rhodiola rosea L. and Its Components for Ischemic Stroke: A Systematic Review and Meta-Analysis

Cai

Mao

et al. 2021

Front. Pharmacol.

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Background:Rhodiola rosea L. has long been used as traditional medicines in Europe and Asia to treat a variety of common conditions and diseases including Alzheimer’s disease, cardiovascular disease, cognitive dysfunctions, cancer, and stroke. Previous studies reported that Rhodiola rosea L. and its components (RRC) improve ischemia stroke in animal models. Here, we conducted a systematic review and meta-analysis for preclinical studies to evaluate the effects of RRC and the probable neuroprotective mechanisms in ischemic stroke.Methods: Studies of RRC on ischemic stroke animal models were searched in seven databases from inception to Oct 2021. The primary measured outcomes included the neural functional deficit score (NFS), infarct volume (IV), brain water content, cell viability, apoptotic cells, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells, B-cell lymphoma-2 (Bcl-2) level and tumor necrosis factor-α (TNF-α) level. The secondary outcome measures were possible mechanisms of RRC for ischemic stroke. All the data were analyzed via RevMan version 5.3.Results: 15 studies involving 345 animals were identified. Methodological quality for each included studies was accessed according to the CAMARADES 10-item checklist. The quality score of studies range from 1 to 7, and the median was 5.53. Pooled preclinical data showed that compared with the controls, RRC could improve NFS (Zea Longa (p < 0.01), modified neurological severity score (mNSS) (p < 0.01), rotarod tests (p < 0.01), IV (p < 0.01), as well as brain edema (p < 0.01). It also can increase cell viability (p < 0.01), Bcl-2 level (p < 0.01) and reduce TNF-α level (p < 0.01), TUNEL-positive cells (p < 0.01), apoptotic cells (p < 0.01).Conclusion: The findings suggested that RRC can improve ischemia stroke. The possible mechanisms of RRC are largely through antioxidant, anti-apoptosis activities, anti-inflammatory, repressing lipid peroxidation, antigliosis, and alleviating the pathological blood brain barrier damage.

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“…Ischemic cerebral vascular disease can cause a different degree of neurological dysfunction and is considered to be a serious threat to public health for its high incidence, high morbidity, high disability, and high mortality characteristics ( Zhong et al, 2019 ; Cai et al, 2021 ). Cerebral ischemia-reperfusion (I/R) injury refers to the phenomenon that the cerebrum suffers from a permanent or transient ischemia and then suddenly restores the blood supply ( Block et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

ATP2B1-AS1 Promotes Cerebral Ischemia/Reperfusion Injury Through Regulating the miR-330-5p/TLR4-MyD88-NF-κB Signaling Pathway

Wang

Tan

Zhu

et al. 2021

Front. Cell Dev. Biol.

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We aim to explore the expression and function of long non-coding RNA (lncRNA) ATP2B1-AS1 in a cerebral ischemia/reperfusion (I/R) injury. In this study, we established a middle cerebral artery occlusion/reperfusion (MCAO/IR) rat model and an OGD/R PC12 cell model to evaluate the expression and role of ATP2B1-AS1 in the cerebral I/R injury. We found that the expression of ATP2B1-AS1 was upregulated in both in vitro and in vivo cerebral I/R injury models. Knockdown of ATP2B1-AS1 increased the cell viability, inhibited apoptosis, and decreased the expressions of inflammation cytokines. The target of ATP2B1-AS1 was predicted and validated to be miR-330-5p. MiR-330-5p abrogated the regulatory effect of ATP2B1-AS1 on cell viability, apoptosis, and cytokines of OGD/R PC12 cells. Furthermore, the results showed that miR-330-5p targeted TLR4, which was also upregulated in the infarcted area of MCAO/IR rats and OGD/R PC12 cells. Overexpression of ATP2B1-AS1 increased the expressions of TLR4, MyD88, and NF-κB p65 of OGD/R PC12 cells, while the effect of ATP2B1-AS1 was abrogated by miR-330-5p. In addition, knockdown of ATP2B1-AS1 decreased the latency time, increased the time of passing the platform position, reduced the cerebral infarct volume, decreased neurological deficit scores, and reduced the number of damaged neurons of MCAO/IR rats that were subjected to the Morris water maze test. Taken together, our study indicates that ATP2B1-AS1 may be an attractive therapeutic target for the treatment of cerebral ischemic injuries.

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Neuroprotective Effects of Salidroside on Cerebral Ischemia/Reperfusion-Induced Behavioral Impairment Involves the Dopaminergic System

Cited by 35 publications

References 70 publications

Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review

Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review

Preclinical Evidence and Possible Mechanisms of Rhodiola rosea L. and Its Components for Ischemic Stroke: A Systematic Review and Meta-Analysis

ATP2B1-AS1 Promotes Cerebral Ischemia/Reperfusion Injury Through Regulating the miR-330-5p/TLR4-MyD88-NF-κB Signaling Pathway

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