Neuroprotective Effects of Salidroside in a Mouse Model of Alzheimer’s Disease

Wang, Hualong; Li, Qiongqiong; Sun, Suya; Chen, Shengdi

doi:10.1007/s10571-020-00801-w

Cited by 43 publications

(26 citation statements)

References 41 publications

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“…In addition, mTOR has been found to be a mammalian target that plays an important role in the formation of AD related memories ( Zhang et al, 2016a ). In a subsequently study, results are similar to Bei et al However, the alteration of mTOR might be influenced by different animal models or drug delivery methods, and the exact mechanisms remain to be investigated ( Wang et al, 2020 ). Additionally, Sal reduces inflammation and brain injury after middle cerebral artery occlusion in rats via PI3K/PKB/Nrf2/NFκB signaling pathway ( Zhang et al, 2019a ).…”

Section: Natural Products For Prevention and Treatment Of Alzheimer’s Disease Based On Pi3k/akt Pathawysupporting

confidence: 68%

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

et al. 2021

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Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, the health problem and economic burden caused by the two diseases also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction and biological processes such as cell proliferation, apoptosis and metabolism. According to reports, it regulates neurotoxicity and mediates the survival of neurons through different substrates such as forkhead box protein Os (FoxOs), glycogen synthase kinase-3β (GSK-3β), and caspase-9. Accumulating evidences indicate that some natural products can play a neuroprotective role by activating PI3K/AKT pathway, providing an effective resource for the discovery of potential therapeutic drugs. This article reviews the relationship between AKT signaling pathway and AD and PD, and discusses the potential natural products based on the PI3K/AKT signaling pathway to treat two diseases in recent years, hoping to provide guidance and reference for this field. Further development of Chinese herbal medicine is needed to treat these two diseases.

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Section: Natural Products For Prevention and Treatment Of Alzheimer’s Disease Based On Pi3k/akt Pathawysupporting

confidence: 68%

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

et al. 2021

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“…Cognitive disorders, such as dementia with AD, raise this bar even further since disorders such as AD are multifactorial in origin. Multiple mechanisms may lead to cognitive impairment and involve cellular injury from β-amyloid (Aβ), tau, excitotoxicity, metabotropic receptors, lipid dysfunction, mitochondrial damage, acetylcholine loss, astrocytic cell injury, oxidative stress, heavy metal disease, and cellular metabolic dysfunction with diabetes mellitus (DM) [3,4,8,14,27,[35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54]. Present strategies to treat cognitive loss with AD involve therapy with cholinesterase inhibitors that may decrease some symptoms but do not alter disease progression [11,15,52,55].…”

Section: Novel Therapeutic Considerations For Cognitive Lossmentioning

confidence: 99%

“…Circadian clock gene pathways through autophagy are reliant upon the mechanistic target of rapamycin (mTOR) [8,86,[150][151][152] (Table 1). mTOR, a 289-kDa serine/threonine protein kinase, is a critical pathway during neurodegenerative disorders and cognitive loss [3,14,50,58,140,[153][154][155]. mTOR is also known as the mammalian target of rapamycin and the FK506-binding protein 12-rapamycin complex-associated protein 1 [14, 87,156,157].…”

Section: Circadian Clock Genes and The Mechanistic Target Of Rapamycinmentioning

confidence: 99%

Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways

Maiese

2021

Biomolecules

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Neurodegenerative disorders affect fifteen percent of the world’s population and pose a significant financial burden to all nations. Cognitive impairment is the seventh leading cause of death throughout the globe. Given the enormous challenges to treat cognitive disorders, such as Alzheimer’s disease, and the inability to markedly limit disease progression, circadian clock gene pathways offer an exciting strategy to address cognitive loss. Alterations in circadian clock genes can result in age-related motor deficits, affect treatment regimens with neurodegenerative disorders, and lead to the onset and progression of dementia. Interestingly, circadian pathways hold an intricate relationship with autophagy, the mechanistic target of rapamycin (mTOR), the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), mammalian forkhead transcription factors (FoxOs), and the trophic factor erythropoietin. Autophagy induction is necessary to maintain circadian rhythm homeostasis and limit cortical neurodegenerative disease, but requires a fine balance in biological activity to foster proper circadian clock gene regulation that is intimately dependent upon mTOR, SIRT1, FoxOs, and growth factor expression. Circadian rhythm mechanisms offer innovative prospects for the development of new avenues to comprehend the underlying mechanisms of cognitive loss and forge ahead with new therapeutics for dementia that can offer effective clinical treatments.

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“…Modern investigations have shown that SLDS has potent protective effects against hepatitis, colitis, skeletal muscle atrophy, and myocardial injury by alleviating excessive inflammation ( Hu B et al, 2014 ; Huang et al, 2019 ; Liu et al, 2019 ; Wang N. et al, 2020 ). Especially, SLDS plays a neuroprotective role in both preclinical models of Alzheimer disease and cerebral ischemia by regulating microglia activation and distribution ( Zhang et al, 2016 ; Liu et al, 2018 ; Wang et al, 2018 ; Zuo et al, 2018 ; Wang H. et al, 2020 ). Studies showed that SLDS could reduce the blood-brain barrier injury by activating the PI3K/Akt signaling pathway, decrease microvascular endothelial cells apoptosis, increase neuron cells viability and promote M2 macrophage/microglial polarization, thus improving functional recovery after cerebral ischemia ( Liuet al, 2018 ; Wang et al, 2018 ; Zuo et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Salidroside Improves Chronic Stress Induced Depressive Symptoms Through Microglial Activation Suppression

Yang

Chen

2021

Front. Pharmacol.

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Depression is a severe neurological disorder highly associated with chronic mental stress stimulation, which involves chronic inflammation and microglial activation in the central nervous system (CNS). Salidroside (SLDS) has been reported to exhibit anti-neuroinflammatory and protective properties on neurological diseases. However, the mechanism underlying the effect of SLDS on depressive symptoms has not been well elaborated. In the present study, the effects of SLDS on depressive behaviors and microglia activation in mice CNS were investigated. Behavioral tests, including Forced swimming test (FST), Open field test (OFT) and Morris water maze (MWM) revealed that SLDS treatment attenuated the depressive behaviors in stress mice. SLDS treatment significantly reduced the microglial immunoreactivity for both Iba-1 and CD68, characteristic of deleterious M1 phenotype in hippocampus of stress mice. Additionally, SLDS inhibited microglial activation involving the suppression of ERK1/2, P38 MAPK and p65 NF-κB activation and thus reduced the expression and release of neuroinflammatory cytokines in stress mice as well as in lipopolysaccharide (LPS)-induced primary microglia. Also, SLDS changed microglial morphology, attachment and reduced the phagocytic ability in LPS-induced primary microglia. The results demonstrated that SLDS treatment could improve the depressive symptoms caused by unpredictable chronic stress, indicating a potential therapeutic application of SLDS in depression treatment by interfering microglia-mediated neuroinflammation.

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Neuroprotective Effects of Salidroside in a Mouse Model of Alzheimer’s Disease

Cited by 43 publications

References 41 publications

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease

Cognitive Impairment and Dementia: Gaining Insight through Circadian Clock Gene Pathways

Salidroside Improves Chronic Stress Induced Depressive Symptoms Through Microglial Activation Suppression

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