Neuroprotective Effects of Rutin in Streptozotocin-Induced Diabetic Rat Retina

Ola, Mohammad Shamsul; Ahmed, Mohammed M.; Ahmad, Rehan; Abuohashish, Hatem M.; Al-Rejaie, Salim S.; Alhomida, Abdullah S.

doi:10.1007/s12031-015-0561-2

Cited by 86 publications

(48 citation statements)

References 56 publications

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“… HFD-STZ-induced type 2 diabetic model Niture 2014 [ 154 ] ↓ Glucose, TBARS, caspase-3 and ↑ insulin, Bcl-2 protein. STZ-induced diabetic rat retina Ola 2015 [ 156 ] Protected pancreatic beta-cell by decreasing oxidative stress. STZ induced diabetic rats Kamalakkannan and Prince 2006 [ 157 ] ↓ MDA levels and ↑ SOD and CAT.…”

Section: Flavonoids and Their Effects On Diabetesmentioning

confidence: 99%

Antidiabetic properties of dietary flavonoids: a cellular mechanism review

2015

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BackgroundNatural food products have been used for combating human diseases for thousands of years. Naturally occurring flavonoids including flavones, flavonols, flavanones, flavonols, isoflavones and anthocyanidins have been proposed as effective supplements for management and prevention of diabetes and its long-term complications based on in vitro and animal models.AimTo summarize the roles of dietary flavonoids in diabetes management and their molecular mechanisms.FindingsTremendous studies have found that flavonoids originated from foods could improve glucose metabolism, lipid profile, regulating the hormones and enzymes in human body, further protecting human being from diseases like obesity, diabetes and their complications.ConclusionIn the current review, we summarize recent progress in understanding the biological action, mechanism and therapeutic potential of the dietary flavonoids and its subsequent clinical outcomes in the field of drug discovery in management of diabetes mellitus.

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Section: Flavonoids and Their Effects On Diabetesmentioning

confidence: 99%

Antidiabetic properties of dietary flavonoids: a cellular mechanism review

2015

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“…MGR is a rutin-glucose conjugate, which is decomposed to rutin or quercetin by digestive enzymes in the small intestine and absorbed as quercetin in the serum [16]. In previous studies, rutin or quercetin showed neuroprotective effects on the rat retina [17,18], retinal function recovery [11,19], and ocular blood flow in animals [11,20]. In particular, quercetin improved dry eye symptoms in mice [21].…”

Section: Discussionmentioning

confidence: 99%

Monoglucosyl rutin facilitates recovery from eyestrain in visual display terminal users: a randomized, placebo-controlled, double-blind, crossover study

Ashigai¹,

Kanaya²,

Fujii³

et al. 2019

Preprint

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BackgroundEyestrain is a serious quality of life problem, especially in the workplace. In particular, work at visual display terminals (VDTs) is a common cause of eyestrain. Currently, there are many workers who work at VDTs and tend to feel eyestrain. Rutin, derived from various food plants such as the Japanese pagoda tree (Styphnolobium japonicum), is a known polyphenol compound. Monoglucosyl rutin (MGR) is a highly water-soluble α-glucose adduct of rutin. Previous studies have demonstrated that rutin improved dry eye and also affected the microvascular blood flow in animal experiments. Based on these findings, we hypothesized that MGR could alleviate eyestrain caused by work at VDTs. In this clinical study, we evaluated whether MGR could improve eyestrain in healthy adults.MethodsThis study was designed as a randomized, placebo-controlled, double-blind, crossover study. Twenty healthy Japanese adults who tended to feel eyestrain were recruited to participate. During the first test period, the participants were asked to drink either a test food containing 377 mg of MGR or a placebo food without MGR. After the food intake, the participants did personal computer work at VDT for 30 min and then relaxed for 20 min. We evaluated the participants’ eyestrain using an objective parameter (high-frequency component 1, HFC1) and subjective parameters (visual analog scale). After 7 days, for the second test period, the participants consumed an alternate food following the same protocol as during the first test period. ResultsThe objective parameter of eyestrain (HFC1) was significantly lower in the MGR group than that in the placebo group. The subjective parameters of eyestrain and waist stiffness were improved in the MGR group in comparison with those in the placebo group.ConclusionsMGR supplementation has the potential to objectively and subjectively improve eyestrain symptoms due to VDT use.

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“…There are reports stating that these compounds confer protection against glutamate-induced apoptosis and ethanol-induced neurotoxicity in hippocampal HT22 cells by reducing caspase 3 activity [46,52]. Ola et al have reported the effectiveness of rutin in ameliorating the levels of neuroprotective factors in streptozotocin-induced diabetic rat retina as it exerts antiapoptotic activity by decreasing the levels of caspase-3 and increasing the levels of Bcl2 [53].…”

Section: Discussionmentioning

confidence: 99%