Neuroprotective effects of rosuvastatin against traumatic spinal cord injury in rats

Kahveci, Ramazan; Gökçe, Emre Cemal; Gürer, Bora; Gökçe, Aysun; Kısa, Üçler; Cemil, Duran Berker; Sargon, Mustafa F.; Kahveci, Fatih Ozan; Aksoy, Nurkan; Erdoğan, Bülent

doi:10.1016/j.ejphar.2014.07.042

Cited by 15 publications

(11 citation statements)

References 62 publications

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“…Likewise, studies in rats using simvastatin [ 162 , 163 ] and rosuvastatin [ 164 ] have observed similar results. Simvastatin (5–10 mg/kg) treatment post-SCI was associated with improved locomotor activity, normalisation of magnetic resonance imaging, increased glial cell-derived neurotrophic factor (GDNF), BDNF, and VEGF expression, and mobilisation of bone marrow stromal cells [ 162 , 163 ].…”

Section: Statins and Neurological Diseasesupporting

confidence: 52%

“…Simvastatin (5–10 mg/kg) treatment post-SCI was associated with improved locomotor activity, normalisation of magnetic resonance imaging, increased glial cell-derived neurotrophic factor (GDNF), BDNF, and VEGF expression, and mobilisation of bone marrow stromal cells [ 162 , 163 ]. Rosuvastatin administration (20 mg/kg) immediately post-spinal cord injury in rats reduced elevations in TNF-α release, myeloperoxidase activity, nitric oxide levels and caspase-3 activity from caudal spinal cord tissue [ 164 ].…”

Section: Statins and Neurological Diseasementioning

confidence: 99%

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Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System

McFarland

Anoopkumar‐Dukie

Arora

et al. 2014

IJMS

157

129

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3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, commonly referred to as statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary and secondary prevention against cardiovascular disease and stroke. Statins’ effects on the central nervous system (CNS), particularly on cognition and neurological disorders such as stroke and multiple sclerosis, have received increasing attention in recent years, both within the scientific community and in the media. Current understanding of statins’ effects is limited by a lack of mechanism-based studies, as well as the assumption that all statins have the same pharmacological effect in the central nervous system. This review aims to provide an updated discussion on the molecular mechanisms contributing to statins’ possible effects on cognitive function, neurodegenerative disease, and various neurological disorders such as stroke, epilepsy, depression and CNS cancers. Additionally, the pharmacokinetic differences between statins and how these may result in statin-specific neurological effects are also discussed.

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Section: Statins and Neurological Diseasesupporting

confidence: 52%

Section: Statins and Neurological Diseasementioning

confidence: 99%

Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System

McFarland

Anoopkumar‐Dukie

Arora

et al. 2014

IJMS

157

129

View full text Add to dashboard Cite

show abstract

“…Several studies have shown therapeutic effects of GDNF in various diseases of the central nervous system, such as Parkinson's disease, stroke and epilepsy (Koppula et al, 2012;Zilliox et al, 2016). In rat models of SCI, the use of statins was associated with improved locomotor activity through up-regulation of Gdnf, Bdnf and Vegf expression (Kahveci et al, 2014). In our study, treatment with lovastatin lead to a significant increase in Gdnf mRNA expression.…”

Section: Discussionsupporting

confidence: 63%

Lovastatin alters neurotrophin expression in rat hippocampus-derived neural stem cells in vitro

Fakheri¹,

Abdanipour²,

Kazem³

et al. 2020

Acta Neurobiologiae Experimentalis

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Neural stem/progenitor cells hold valuable potential for the treatment of neurodegenerative disorders. The modulation of intrinsic growth factor expression, such as neurotrophins and their receptors, is a necessary step in achieving neural stem cells (NSCs) therapy. The statins have recently been reported to provide both anti-inflammatory and neuroprotective effects. In the developing and mature nervous systems, neurotrophic factors are known to impact neuronal growth and survival. In this study, we investigated for a positive effect of lovastatin on the expression of neurotrophins in the neonatal rat hippocampus-derived NSCs. NSCs were isolated and cultured up to passage three. To confirm cellular identity, immunocytochemical evaluation and flow cytometry analysis were performed using specific antibodies. To determine the optimum concentration of lovastatin, the MTT assay was used. Neurotrophin expression was evaluated using quantitative real-time reverse transcription-polymerase chain reaction (RT-qPCR). Flow cytometry results demonstrated that NSCs were positive for nestin, a marker for neural progenitor cells. An increase in cellular viability was observed with a 24 h exposure of lovastatin. Moreover, results showed an increase in mRNA expression for all neurotrophins compared to the control group. Taken together, the results of this study add to the growing body of literature on the neuroprotective effects of statins in neurological disorders. Lovastatin is a promising therapeutic agent for the treatment of neurodegenerative disorders.

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“…An investigation by the Publisher found it to be one of a group of articles we have identified as showing evidence suggestive of attempts to subvert the peer review and publication system to inappropriately obtain or allocate authorship. This article showed evidence of plagiarism (most notably from the articles cited [2–5]) and authorship manipulation.…”

Section: Retractionmentioning

confidence: 91%

Retraction note: Serotonin 5-HT7 receptor agonist, LP-211, exacerbates Na+, K+-ATPase/Mg2+ ATPase imbalances in spinal cord-injured male rats

et al. 2016

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Neuroprotective effects of rosuvastatin against traumatic spinal cord injury in rats

Cited by 15 publications

References 62 publications

Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System

Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System

Lovastatin alters neurotrophin expression in rat hippocampus-derived neural stem cells in vitro

Retraction note: Serotonin 5-HT7 receptor agonist, LP-211, exacerbates Na+, K+-ATPase/Mg2+ ATPase imbalances in spinal cord-injured male rats

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