Neuroprotective effects of Rehmannia glutinosa polysaccharide on chronic constant light (CCL)-induced oxidative stress and autophagic cell death via the AKT/mTOR pathway in mouse hippocampus and HT-22 cells

Yang, Yang; Yu, Lin; Zhu, Tianyu; Xu, Shuwen; He, Jin; Mao, Ningning; Liu, Zhenguang; Wang, Deyun

doi:10.1016/j.ijbiomac.2024.129813

Cited by 1 publication

(1 citation statement)

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“…In a rat model of gastric cancer precancerous lesion (PLGC), the levels of PI3K, p -AKT and HIF-α were significantly upregulated, whereas the levels of PI3K, p-AKT and HIF-α were suppressed after Fufang E’jiao Jiang administration ( Shi et al, 2023 ). The independent effects of CP( He et al, 2022 ) and other components of Fufang E’jiao Jiang ( Chin et al, 2023 ; Lien et al, 2023 ; Omrani et al, 2024 ; Yang et al, 2024 ) in diseases have been studied. However, the strength of CP’s efficacy when used independently versus as a component of Fufang E’jiao Jiang has not been thoroughly investigated.…”

Section: Subsections Relevant For the Subjectmentioning

confidence: 99%

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Guo,

Lou,

Hou

et al. 2024

Front. Pharmacol.

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As a traditional Chinese medicinal herb with a long history, Codonopsis pilosula (CP) has attracted much attention from the medical community in recent years. This review summarizes the research progress of CP in the medical field in the past 5 years. By searching and analyzing the literature, and combining with Cytoscape software, we comprehensively examined the role and mechanism of action of CP in individual application, combination drug application, and the role and mechanism of action of codonopsis pilosula’s active ingredients in a variety of diseases. It also analyzes the medicinal use of CP and its application value in medicine. This review found that CP mainly manifests important roles in several diseases, such as cardiovascular system, nervous system, digestive system, immune system, etc., and regulates the development of many diseases mainly through the mechanisms of inflammation regulation, oxidative stress, immunomodulation and apoptosis. Its rich pharmacological activities and diverse medicinal effects endow CP with broad prospects and application values. This review provides valuable reference and guidance for the further development of CP in traditional Chinese medicine.

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