Neuroprotective effects of quercetin in a mouse model of brain ischemic/reperfusion injury via anti-apoptotic mechanisms based on the Akt pathway

Li, Xiaoming; Chao, Hailian; Zhang, Zhenni; Lv, Jianrui; Siyuan, Li; Wei, Haidong; Xue, Renyu; Li, Fang; Li, Zongfang

doi:10.3892/mmr.2015.3857

Cited by 71 publications

(32 citation statements)

References 36 publications

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“…These studies exhibited their beneficial effect as neuroprotective agents. Among these compounds are quercetin [41], gallic acid [42, 43], catechin [44], and emodin [45]. Additionally, many phenolic compounds were previously reported as neuroprotective [46], whereas P. austroarabica extract is considered to accumulate a considerable amount of phenolic constituents.…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant and Neuroprotective Activities of Phragmanthera austroarabica Extract in Pentylenetetrazole‐Kindled Mice

Aldawsari

Eid

Neamatallah

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Anticonvulsant and neuroprotective activity of Phragmanthera austroarabica extract were tested in pentylenetetrazole-kindled mice. All the chemical constituents of the plant extract were identified. Additionally, the extract was standardized and proved to contain total phenolic contents equal to 379.92 ± 1.32 mg gallic acid equivalents/g dry plant extract. Induction of kindling was achieved by repeated intraperitoneal administration of pentylenetetrazole (35 mg/kg) twice weekly. Male albino mice were given P. austroarabica extract (200, 400, or 800 mg/kg). The two higher doses (400 or 800 mg/kg) of the extract significantly caused notable reduction in seizure activity and hippocampal malondialdehyde level compared to pentylenetetrazole control group. The highest dose enhanced cortical GSH level and showed intact DNA in the laddering assay. Upon studying the neuroprotective effect, mice treated with the higher dose of the extract demonstrated an improvement in the percent of surviving neurons in the cortex and hippocampus. We concluded that P. austroarabica extract ameliorated seizure activity and protected cortical and hippocampal neurons against pentylenetetrazole-induced kindling in mice.

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Section: Discussionmentioning

confidence: 99%

Anticonvulsant and Neuroprotective Activities of Phragmanthera austroarabica Extract in Pentylenetetrazole‐Kindled Mice

Aldawsari

Eid

Neamatallah

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Quercetin has been shown to induce several positive effects in CVS such as blood pressure lowering effects (Perez-Vizcaino et al 2009, Larson et al 2012 or protective effects on hearts exposed to I/R injury (Ikizler et al 2007, Bartekova et al 2010. It has been also documented that quercetin exerts protective effects in non-cardiac I/R models such as renal (Singh et al 2004, Chen et al 2014), brain (Yao et al 2012, Lei et al 2015) or liver (Su et al 2003, Tokyol et al 2006 ischemia. It has been demonstrated that the efficiency of certain protective interventions against I/R injury may be age-dependent.…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective Effects of Quercetin Against Ischemia-Reperfusion Injury Are Age-Dependent

Barteková

Radošinská²,

Pancza³

et al. 2016

Physiol Res

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Quercetin, a polyphenolic compound present in various types of food, has been shown to exert beneficial effects in different cardiac as well as non-cardiac ischemia/reperfusion (I/R) models in adult animals. However, there is no evidence about the effects of quercetin on I/R injury in non-mature animals, despite the fact that efficiency of some interventions against I/R is age-dependent. This study was aimed to investigate the effects of chronic quercetin treatment on I/R injury in juvenile and adult rat hearts. Juvenile (4-week-old) as well as adult (12-week-old) rats were treated with quercetin (20 mg/kg/day) for 4 weeks, hearts were excised and exposed to 25-min global ischemia followed by 40-min reperfusion. Functional parameters of hearts and occurrence of reperfusion arrhythmias were registered to assess the cardiac function. Our results have shown that quercetin improved post-ischemic recovery of LVDP, as well as recovery of markers of contraction and relaxation, +(dP/dt)max and –(dP/dt)max, respectively, in juvenile hearts, but not in adult hearts. Quercetin had no impact on incidence as well as duration of reperfusion arrhythmias in animals of both ages. We conclude that the age of rats plays an important role in heart response to quercetin treatment in the particular dose and duration of the treatment. Therefore, the age of the treated subjects should be taken into consideration when choosing the dose of quercetin and duration of its application in prevention and/or treatment of cardiovascular diseases.

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“…Root of A. speciosa rich with quercetin, caffeic acid and coumarin. Many investigators claim that quercetin possesses the anti-stroke activity 55,56,57 . Apart from this, coumarin and its derivatives compounds also attenuated the cerebral ischemic/reperfusion injury 58,59,60 .…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Ethanolic Extract From the Root of Argyreia Speciosa Against Global Cerebral Ischemic Reperfusion Injury in Rats

Jaiswal

Tailang

2018

J. Drug Delivery Ther.

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Cerebral stroke is the principal reason of death without effective treatment in the world and recognized as the common cause of disability. Argyreia speciosa (Linn.f.) (Convolvulaceae, Synonyms: Argyreia nervosa) is widely distributed plant species in India. It is commonly known as Elephant creeper and Vryddhadaru. A. speciosa is a very valuable plant in the Ayurvedic system. In 'Rasayan' drug it has been used for the treatment of various neurological diseases. Its root taste is bitter and having the multiple uses like as a brain tonic, nootropic, anti-anxiety and anticonvulsant activity. The current study, plan to investigate the neuroprotective effect of ethanolic extract of A. speciosa root (ASEE) in a validate rat model of stroke known as global cerebral ischemic reperfusion injury (GCIRI). We divided 36 male Wistar rats to six experimental groups (n= 6). The group-I considered as sham control (no GCIRI), Group-II saline treated GCIRI, Group-III, IV, and V received ASEE (100, 200 and 400 mg/kg, p.o.) for 7 days prior to the induction of GCIRI while Group-VI termed as standard and it received quercetin (20 mg/kg, i.p.) 30 min prior induction of GCIRI. GCIRI produced the significant neurological deficit, sensorimotor dysfunction, decrease neurobehavioral parameters, increased cerebral infarction area and brain edema as compared with sham control rats. Seven days of pretreatment with ASEE markedly attenuates all the changes caused by GCIRI to the normal level. Our results proved that ASEE possess the protective effect on GCIRI induced stroke and aforementioned neuroprotection may be due to its antioxidant and anti-inflammatory property. Keywords: Brain stroke, BCCAO, Antioxidants, Neuroprotection, Argyreia speciosa

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Neuroprotective effects of quercetin in a mouse model of brain ischemic/reperfusion injury via anti-apoptotic mechanisms based on the Akt pathway

Cited by 71 publications

References 36 publications

Anticonvulsant and Neuroprotective Activities of Phragmanthera austroarabica Extract in Pentylenetetrazole‐Kindled Mice

Anticonvulsant and Neuroprotective Activities of Phragmanthera austroarabica Extract in Pentylenetetrazole‐Kindled Mice

Cardioprotective Effects of Quercetin Against Ischemia-Reperfusion Injury Are Age-Dependent

Protective Effect of Ethanolic Extract From the Root of Argyreia Speciosa Against Global Cerebral Ischemic Reperfusion Injury in Rats

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