Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage

Akar, Ali; Öztopuz, Özlem; Bűyűk, Başak; Ovalı, Mehmet Akif; Aykora, Damla; Malçok, Ümit Ali

doi:10.1007/s12035-023-03306-x

Cited by 4 publications

(2 citation statements)

References 72 publications

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“…Bcl-2 can play an anti-apoptotic role, and the overexpression of Bcl-2 can lead to changes of the REDOX balance in the nucleus, thereby reducing the activity of Caspase. Bax is a member of the Bcl-2 family involved in apoptosis, which can induce apoptosis, and the Bax/Bcl-2 ratio is a switch that initiates apoptosis (Akar et al 2023 ; Eraslan et al 2021 ; Li et al 2019 ) The expression of cells and apoptosis factors (Caspase-3, Caspase-9, Bax, Bcl-2) were measured by RT-qPCR to explore the protective ability of AP-1-L on cells. After UVB irradiation, the relative expression level of proapoptotic factor in the model group were significantly increased, and the relative expression level of proapoptotic factor significantly decreased after AP-1-L irradiation.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells

Wang,

Zhang,

Wang

et al. 2023

Bioresour. Bioprocess.

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Background Aureobasidium pullulans (A. pullulans) has a wide range of applications. Ultraviolet (UV) rays from the sun can cause skin photoaging. In order to explore the protective effect and application potential of A. pullulans lysate on UV-damaged human skin fibroblasts (HSF) and HaCaT Cells, this study investigates the anti-aging and anti-inflammatory effects of A. pullulans lysate as well as the mechanism of anti-oxidative stress at the cellular and molecular levels through cytotoxicity experiments, enzyme-linked immunosorbent assays (ELISA), and real-time quantitative PCR (RT-qPCR). Results The experimental results have shown that the A. pullulans lysate can effectively reduce the loss of extracellular matrix components (EMC), such as collagen and hyaluronic acid (HA). It is also capable of scavenging excess reactive oxygen species (ROS) from the body, thereby increasing the activity of catalase, decreasing the overexpression of intracellular matrix metalloproteinases (MMPs), enhancing the gene expression of metalloproteinase inhibitors (TIMPs), and decreasing the level of inflammatory factors, reducing UV-induced apoptosis of HaCaT cells. Meanwhile, oxidative stress homeostasis is also regulated through the Nrf2/Keap1 and MAPK signaling pathways. Conclusions This study shows that the A. pullulans lysate has the potential to resist photoaging. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells

Wang,

Zhang,

Wang

et al. 2023

Bioresour. Bioprocess.

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“…Stroke due to a subarachnoid hemorrhage can injure the olfactory bulb. PICE is seen to suppress cytokines such as TNF-α and IL-6, and components of the inflammatory pathways such as NF-κB and SIRT1, in a rat model of olfactory bulb damage [149].…”

Section: Effect Of Stilbenes On Ache and Buchementioning

confidence: 95%

Stilbenes, a Versatile Class of Natural Metabolites for Inflammation—An Overview

et al. 2023

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Stilbenes are polyphenolic allelochemicals synthesized by plants, especially grapes, peanuts, rhubarb, berries, etc., to defend themselves under stressful conditions. They are now exploited in medicine for their antioxidant, anti-proliferative and anti-inflammatory properties. Inflammation is the immune system’s response to invading bacteria, toxic chemicals or even nutrient-deprived conditions. It is characterized by the release of cytokines which can wreak havoc on healthy tissues, worsening the disease condition. Stilbenes modulate NF-κB, MAPK and JAK/STAT pathways, and reduce the transcription of inflammatory factors which result in maintenance of homeostatic conditions. Resveratrol, the most studied stilbene, lowers the Michaelis constant of SIRT1, and occupies the substrate binding pocket. Gigantol interferes with the complement system. Besides these, oxyresveratrol, pterostilbene, polydatin, viniferins, etc., are front runners as drug candidates due to their diverse effects from different functional groups that affect bioavailability and molecular interactions. However, they each have different thresholds for toxicity to various cells of the human body, and thus a careful review of their properties must be conducted. In animal models of autoinflammatory diseases, the mode of application of stilbenes is important to their absorption and curative effects, as seen with topical and microemulsion gel methods. This review covers the diversity seen among stilbenes in the plant kingdom and their mechanism of action on the different inflammatory pathways. In detail, macrophages’ contribution to inflamed conditions in the liver, the cardiac, connective and neural tissues, in the nephrons, intestine, lungs and in myriad other body cells is explored, along with detailed explanation on how stilbenes alleviate the symptoms specific to body site. A section on the bioavailability of stilbenes is included for understanding the limitations of the natural compounds as directly used drugs due to their rapid metabolism. Current delivery mechanisms include sulphonamides, or using specially designed synthetic drugs. It is hoped that further research may be fueled by this comprehensive work that makes a compelling argument for the exploitation of these compounds in medicine.

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Investigation of the protective effects of piceatannol on experimental subarachnoid hemorrhage in rats

Erbil,

Uzun

2024

Mol Biol Rep

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Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage

Cited by 4 publications

References 72 publications

Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells

Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells

Stilbenes, a Versatile Class of Natural Metabolites for Inflammation—An Overview

Investigation of the protective effects of piceatannol on experimental subarachnoid hemorrhage in rats

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