Neuroprotective Effects of Peptides in the Brain: Transcriptome Approach

Filippenkov, Ivan B.; Dergunova, Lyudmila V.; Limborska, Svetlana A.; Myasoedov, N. F.

doi:10.1134/s0006297920030037

Cited by 3 publications

(3 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we used several biologically active corticotropins with anxiolytic effects that may be associated with the GABAR system. The effect of some peptides on gene transcription in nerve cells in norm and under pathological conditions has been shown (Denisova et al, 2018; Dergunova et al, 2021; Filippenkov et al, 2020), including the effect on GABAR system genes (Filatova et al, 2017). It has previously been demonstrated that peptides ACTH(4‐7)PGP and ACTH(6‐9)PGP attenuated behavioral alteration induced by acute restraint stress (Filippenkov et al, 2021; Glazova et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Synthetic corticotropins and the GABA‐receptor system: Direct and delayed effects

et al. 2023

View full text Add to dashboard Cite

The central effectors of the stress system are greatly interconnected and include, among others, a large group of peptides derived from proopiomelanocortin. In addition to natural corticotropins, a number of artificial molecules that contain some ACTH fragments in their structure are also referred to members of this family. Some of them possess a wide range of biological activity. The molecular mechanism underlying the biological activity of such peptides is partly based on allosteric modulation of various receptors. We analyzed the ability of some biologically active synthetic corticotropins (ACTH(4‐7)PGP, ACTH(6‐9)PGP, ACTH(7‐10)PGP), and glyproline PGPL to affect the GABA‐receptor system of rat brain. The effects of the peptides were studied in the isolated plasma membranes of brain cells, as well as after systemic peptide administration in the rat model of acute restraint stress. The delayed effect of stress or preadministration of each of the studied peptides on [3H]GABA binding was different for its high‐ and low‐affinity‐specific sites. The studied peptides individually affected the binding of [3H]GABA in their own way. Acute restraint stress caused a decrease in [3H]GABA binding at its low‐affine site and did not affected the high‐affine site. Preliminary peptide administration did not influence this effect of stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Synthetic corticotropins and the GABA‐receptor system: Direct and delayed effects

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Применение соединений Thr-Lys-Pro-Arg-Pro-Gly-Pro и Pro-Gly-Pro в условиях экспериментального гипертиреоза привело к изменениям интенсивности процессов ПОЛ, ПОБ и восстановлению уровней активности антиоксидантных ферментов -СОД и каталазы в гипоталамической области головного мозга крыс. Мы предполагаем, что молекулы Thr-Lys-Pro-Arg-Pro-Gly-Pro и Pro-Gly-Pro, проникая через гематоэнцефалический барьер, блокируют повреждения, вызванные ПОЛ, а также участвуют в инактивации свободных радикалов [12,14,15].…”

Section: Fig 3 the Effect Of Glyprolins On The Parameters Of The Enzy...unclassified

Effects of Glyprolins on Lipid and Protein Peroxidation in the Hypothalamic Region in Experimental Hyperthyroidism

Sergalieva,

Tsibizova,

Samotrueva

2024

BIOMEDICINE

View full text Add to dashboard Cite

We investigate effects of glyproline-type neuropeptides on lipid and protein peroxidation in the hypothalamic brain region of rats under the conditions of experimental hyperthyroidism. The state of hyperthyroidism in animals was simulated by intragastric administration of sodium pentahydrate of L-thyroxine at a dose of 150 µg/kg for 21 days. The following experimental groups (n=10) were formed: 1) control group — intact animals (control); 2) animals treated with L-thyroxine sodium salt pentahydrate (hyperthyroidism); 3) animals treated with Thr-Lys-Pro-Arg-Pro-Gly-Pro (celank); 4) animals treated with Pro-GlyPro (doses of 87 and 33 µg/kg/day, respectively) intraperitoneally daily during 21 days starting one day after the last administration of sodium pentahydrate of L-thyroxine. The level of lipid peroxidation processes was assessed by the initial level of TBA-reactive products, spontaneous and ascorbate-dependent lipid peroxidation rates in hypothalamic tissue homogenate. Protein peroxidation products were determined by the reaction between oxidized amino acid residues of proteins and 2,4-dinitrophenylhydrazone. The enzymatic part of the antioxidant system of hypothalamic region was estimated by measuring the activity of superoxide dismutase and catalase. In the setting of Thr-Lys-Pro-Arg-Pro-Gly-Pro and Pro-Gly-Pro administration under experimental hyperthyroidism, the intensity of lipid and protein peroxidation processes was decreased, while the activity of antioxidant enzymes-superoxide dismutase and catalase was restored in the hypothalamic tissue. The experimental data obtained indicate that, under the conditions of experimental hyperthyroidism, Thr-Lys-Pro-Arg-Pro-Gly-Pro and Pro-Gly-Pro compounds exhibit an antioxidant and antiradical activity with respect to parameters of lipoperoxidation and oxidative modification of proteins, as well as with respect to enzymatic defense systems in the hypothalamic brain region of laboratory animals.

show abstract

“…Understanding the circRNA/miRNA/mRNA system is critical for insight into the process of brain damage and healing. Ischemia-induced gene activity changes and peptide-mediated transcriptome spectrum alterations in experimental ischemia were reviewed by Filipenkov et al [ 49 ], who also explained the underlying concept of peptide regulation in ischemia-induced damage. He et al [ 50 ] successfully established the MCAO rat model for the first time and injected 10 mg/kg fluoxetine hydrochloride intraperitoneally for 14 days to study the function of fluoxetine in cerebral IS and the identification of fluoxetine mediated circRNA-miRNA-mRNA axis.…”

Section: Potential Role Of Circrnas In the Treatment Of Ismentioning

confidence: 99%