Neuroprotective effects of oolong tea extracts against glutamate-induced toxicity in cultured neuronal cells and β-amyloid-induced toxicity in<i>Caenorhabditis elegans</i>

Zhang, Shaoxiong; Duangjan, Chatrawee; Liu, Jianghong; Lin, Juan

doi:10.1039/d0fo01072c

Cited by 32 publications

(36 citation statements)

References 43 publications

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“…We suggested that the optimal concentration of AO extract is need for antioxidant and protective properties (Supplementary Material Figure S4). The neuroprotective effects of AO extracts are consistent with antioxidant properties against neurotoxicity of anacardic acids (Salehi et al, 2019), gallic acid (Oiram Filho et al, 2018), catechin (Herges et al, 2011;Zhang et al, 2020) and quercetin (Yang et al, 2014;Khan et al, 2018;Park et al, 2019).…”

Section: Involvement Of Signaling Pathway In Anacardium Occidentale L Extracts Induced Neurite Outgrowth In Neuro-2a Cellssupporting

confidence: 61%

“…For Teneurin-4 (Ten-4) knockdown, On-Target Plus small interfering RNA (siRNA), which contains the targeting sequence of Ten-4 (Thermo Fisher Scientific), was used. Specific siRNAs of the Ten-4 gene were designed according to Suzuki et al (2014) , Zhang et al (2020) (sense: 5′- GAUUGUGGCAAACUAGUAU-3′, antisense: 5′- AUACUAGUUUGCCACAAUC-3′). Transfection of Neuro-2a cells was accomplished using Lipofectamine ® 2000 (Invitrogen; Thermo Fisher Scientific, Inc.).…”

Section: Methodsmentioning

confidence: 99%

“…Results demonstrated that the protective effect of AO extracts against glutamate/H 2 O 2 -induced cytotoxicity was achieved not only by suppressing intracellular ROS production, but also through enhancing the expression of endogenous antioxidant enzymes. The neuroprotective effects of AO extracts may occur because of antioxidant activity from bioactive compounds such as palmitic acid (Ghareghani et al, 2017), α-linolenic acid (Lee et al, 2018), gallic acid (Oiram Filho et al, 2018), catechin (Herges et al, 2011;Zhang et al, 2020), and quercetin (Yang et al, 2014;Khan et al, 2018;Park et al, 2019), which were found in several studies to have neuroprotective properties.…”

Section: Effect Of Anacardium Occidentale L Extracts On Gene Expression Of Antioxidant Enzymes In Ht22 and Neuro-2a Cellsmentioning

confidence: 99%

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Anacardium Occidentale L. Leaf Extracts Protect Against Glutamate/H2O2-Induced Oxidative Toxicity and Induce Neurite Outgrowth: The Involvement of SIRT1/Nrf2 Signaling Pathway and Teneurin 4 Transmembrane Protein

et al. 2021

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Neurodegenerative diseases are linked to neuronal cell death and neurite outgrowth impairment that are often caused by oxidative stress. Natural products, which have neuroprotective against oxidative stress and neurite outgrowth inducing activity, could be potential candidates for alternative treatment of neurodegenerative diseases. This study aims to investigate the neuroprotective effects and neuritogenesis properties of Anacardium occidentale leaf extracts in cultured neuronal (HT22 and Neuro-2a) cells. We found gallic acid, catechin and quercetin as the main compounds in A. occidentale extracts. The extracts have a protective effect against glutamate/H2O2-mediated oxidative stress-induced cell toxicity. The gene expression of cellular antioxidant enzymes (SODs, GPx and, GSTs) were up-regulated by this treatment. The treatment also triggered SIRT, Nrf2 proteins as well as the mRNA transcriptions of relevant anti-oxidation genes (NQO1, GCLM, and EAAT3). We demonstrated that the extracts promote antioxidant defense in neuronal cells via the SIRT1/Nrf2 signaling pathway. Moreover, the extracts increase neurite outgrowth and Ten-4 expression in Neuro-2a cells. However, the neuritogenesis properties did not occur, when Ten-4 expression was knocked down by corresponding siRNA. These results suggest that the leaf extracts have an interesting neuritogenesis and neuroprotective potential against glutamate/H2O2-mediated toxicity and could be a potential therapeutic candidate for neurodegenerative diseases.

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Section: Involvement Of Signaling Pathway In Anacardium Occidentale L Extracts Induced Neurite Outgrowth In Neuro-2a Cellssupporting

confidence: 61%

Section: Methodsmentioning

confidence: 99%

Section: Effect Of Anacardium Occidentale L Extracts On Gene Expression Of Antioxidant Enzymes In Ht22 and Neuro-2a Cellsmentioning

confidence: 99%

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Anacardium Occidentale L. Leaf Extracts Protect Against Glutamate/H2O2-Induced Oxidative Toxicity and Induce Neurite Outgrowth: The Involvement of SIRT1/Nrf2 Signaling Pathway and Teneurin 4 Transmembrane Protein

et al. 2021

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“…These extracts also increased the average neurite length and induced the expression of GAP-43 and Ten-4 involved in neural development in Neuro-2a cells. Moreover, they had protective effects against Aβ-induced paralysis, chemotaxis deficiency, and α-synuclein aggregation in C. elegans [ 141 ]. Teaghrelin, a compound in oolong tea, activated AMP-activated protein kinase (AMPK)/sirtuin 1(SIRT1)/peroxisome proliferator-activated receptor gamma (PPARγ) coactivator-1α (PGC-1α) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathways in SH-SY5Y cells to antagonize mitochondrial toxin, MPP + -induced cell death [ 142 ].…”

Section: Herbal Teas and Autophagymentioning

confidence: 99%

Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health

et al. 2021

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Tea is one of the most popular and widely consumed beverages worldwide, and possesses numerous potential health benefits. Herbal teas are well-known to contain an abundance of polyphenol antioxidants and other ingredients, thereby implicating protection and treatment against various ailments, and maintaining overall health in humans, although their mechanisms of action have not yet been fully identified. Autophagy is a conserved mechanism present in organisms that maintains basal cellular homeostasis and is essential in mediating the pathogenesis of several diseases, including cancer, type II diabetes, obesity, and Alzheimer’s disease. The increasing prevalence of these diseases, which could be attributed to the imbalance in the level of autophagy, presents a considerable challenge in the healthcare industry. Natural medicine stands as an effective, safe, and economical alternative in balancing autophagy and maintaining homeostasis. Tea is a part of the diet for many people, and it could mediate autophagy as well. Here, we aim to provide an updated overview of popular herbal teas’ health-promoting and disease healing properties and in-depth information on their relation to autophagy and its related signaling molecules. The present review sheds more light on the significance of herbal teas in regulating autophagy, thereby improving overall health.

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“…For Teneurin-4 (Ten-4) knockdown, On-Target Plus small interfering RNA (siRNA), which contains the targeting sequence of Ten-4 (Thermo Fisher Scientific), was used. Specific siRNAs of the Ten-4 gene were designed according to Suzuki et al (2014), Zhang et al (2020) (sense: 5′-GAUUGUGGCAAACUA GUAU-3′, antisense: 5′-AUACUAGUUUGCCACAAUC-3′). Transfection of Neuro-2a cells was accomplished using Lipofectamine ® 2000 (Invitrogen; Thermo Fisher Scientific, Inc.).…”

Section: Knockdown Of Teneurin-4 Expressionmentioning

confidence: 99%

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Neuroprotective effects of oolong tea extracts against glutamate-induced toxicity in cultured neuronal cells and β-amyloid-induced toxicity inCaenorhabditis elegans

Abstract: The schematic of neuroprotective effects of oolong tea extracts against glutamate-induced toxicity in cultured neuronal cells and Aβ/α-synuclein-induced toxicity in Caenorhabditis elegans.

Cited by 32 publications

References 43 publications

Anacardium Occidentale L. Leaf Extracts Protect Against Glutamate/H2O2-Induced Oxidative Toxicity and Induce Neurite Outgrowth: The Involvement of SIRT1/Nrf2 Signaling Pathway and Teneurin 4 Transmembrane Protein

Anacardium Occidentale L. Leaf Extracts Protect Against Glutamate/H2O2-Induced Oxidative Toxicity and Induce Neurite Outgrowth: The Involvement of SIRT1/Nrf2 Signaling Pathway and Teneurin 4 Transmembrane Protein

Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health

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