Neuroprotective effects of lacosamide in experimental traumatic spinal cord injury in rats

Abstract

AIM: To evaluate the effects of lacosamide on traumatic spinal cord injury (SCI) in rats. MATERIAL and METHODS: A total of 28 male Wistar albino rats, each weighing 300-350 g, were included. They were randomly assigned to four groups. In Group 1, only a laminectomy was performed; in Group 2, SCI was performed after laminectomy; in Group 3, SCI was performed after laminectomy followed by lacosamide administration, and in Group 4, SCI was performed after laminectomy followed by physiological saline administration. After 48 hours, all animals were sacrificed, blood samples were drawn, and their spinal cords were removed. The serum levels of catalase, glutathione peroxidase (GPx), superoxide dismutase (SOD) and malondialdehyde (MDA) were measured, and the spinal cord specimens were examined for neuronal degeneration (PND). RESULTS: The MDA level was the lowest and the antioxidant enzyme levels were the highest in Group 3. There were statistically significant differences between Group 3 and the others in their PND score, serum MDA, SOD, GPX and catalase levels (p<0.05). CONCLUSION: Lacosamide has a neuroprotective effect in SCI in rats that is related to its ability to decrease the production of reactive oxygen species by increasing antioxidant enzyme expression, inhibit lipid peroxidation and attenuate glial cell activation.

Neuroprotective Effects of Lacosamide in Experimental Peripheral Nerve Injury in Rats : A Prospective Randomized and Placebo-Controlled Trial

“…In the current study, we had similar results to our previous study (lacosamide treatment after spinal cord injury) 8) . Histopathological results represented that there is lower damage in group III which was treated with lacosamide when compared with the others.…”

“…Several studies have reported that it exhibits antioxidant, anti-inflammatory and lipid peroxidation inhibiting effect which are the main scope of the treatment strategy for neural damage after PNI 1,13,22) . We have also reported in our previous study that lacosamide has neuroprotective effects after spinal cord injury 8) . So, when consider the anti-inflammatory, antioxidant, and inhibiting lipid peroxidation properties and protective effects of lacosamide on neural tissue after experimental spinal cord injury, we hypothesized that it may provide neuroprotective effects after traumatic PNI.…”

Anticonvulsant Effects of Topiramate and Lacosamide on Pilocarpine-Induced Status Epilepticus in Rats: A Role of Reactive Oxygen Species and Inflammation

“…LCM has also been shown to reverse the brain lipid peroxidation and to increase the SOD activity in a strychnine-induced seizure model [33]. Besides, LCM attenuates both the MDA levels in serum and the glial activation in a model of traumatic spinal cord injury [45].…”

Effects of Lacosamide Treatment on Epileptogenesis, Neuronal Damage and Behavioral Comorbidities in a Rat Model of Temporal Lobe Epilepsy

“…Our results are in agreement with a previous study which has demonstrated that LCM decreased the formation of free radicals 48 h after SE induced by Pilo, since the authors reported reduced MDA levels and increased GSH levels [ 59 ]. Moreover, recent studies have revealed the antioxidant properties of LCM in an experimental model of traumatic spinal cord injury and lipopolysaccharide-induced neuroinflammation through increasing the levels of total antioxidant status in different brain areas such as the hippocampus, cortex, and cerebellum [ 60 , 61 ]. Chronic oxidative stress is also associated with cognitive dysfunction, therefore, the decrease of the levels of free radicals caused by LCM could have long-term effects and be responsible for the seizure attenuation and better cognitive performance of the animals treated with it during epileptogenesis, thus producing a disease-modifying effect such as preventing the occurrence of anxiety and depressive-like symptoms.…”