Neuroprotective Effects of Intramuscular Ketamine in Rabbit Retinas After Pars Plana Vitrectomy and Silicone Oil Injection

Pâques, M.; Guizzo, Renato; Siqueira, Rubens Camargo; Silva, Antônio R. M.; Cardillo, J.A.; Flynn, Harry W.; Santos, Wagner Ferreira dos; Jorge, Rodrigo

doi:10.1097/00006982-200602000-00013

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…11,13,14 In addition, reports of SO emulsification at the macula suggest that irreversible damage may be caused by eventual foveal accumulation of SO, 15 which is supported by findings of intraretinal spherical globules similar in appearance to SO in vitreous cavity on OCT. 23 There are conflicting data from animal and histopathological studies regarding a toxic effect of SO on the retina. [24][25][26][27][28][29] In rabbit eyes injected with SO, retinal cell death and disorganization were identified 26 as well as lesions in the outer plexiform layer that were only observed in areas of direct contact with the oil. 24 Damage to the retina may be caused by a localized inflammatory response mediated by macrophages.…”

Section: Discussionmentioning

confidence: 99%

“…There are conflicting data from animal and histopathological studies regarding a toxic effect of SO on the retina. 24 -29 In rabbit eyes injected with SO, retinal cell death and disorganization were identified 26 as well as lesions in the outer plexiform layer that were only observed in areas of direct contact with the oil. 24 Damage to the retina may be caused by a localized inflammatory response mediated by macrophages.…”

Section: Discussionmentioning

confidence: 99%

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Macular Changes on Optical Coherence Tomography Before, During, and After Silicone Oil Tamponade for Macula-On Retinal Detachment: A Case Series

Kheir

Mehanna

Koaik

et al. 2018

Journal of VitreoRetinal Diseases

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Assess changes on spectral domain optical coherence tomography (OCT) before, during, and after removal of silicone oil (SO). Methods: Retrospective series of patients who underwent SO tamponade for macula-on rhegmatogenous retinal detachment. OCT scans of the affected eye were taken before, during, and 3 months after SO tamponade. Qualitative assessment of foveal contour and quantitative comparison of OCT parameters (central macular, cube, ganglion cell layer [GCL], and outer retinal thicknesses) were done between 3 time points. Results: Ten eyes of 9 patients were included. Flattening of the foveal contour during SO tamponade was completely reversed after SO removal. Average cube and GCL thicknesses decreased with SO tamponade and increased after SO removal (P ¼ .01 and P ¼ .02, respectively). Outer retinal thicknesses did not vary among 3 time points (P ¼ .09). Conclusions: SO tamponade causes foveal flattening and thinning of the inner retinal layers, which is reversible on removal.

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