Neuroprotective effects of <i>Lepidium meyenii</i> (Maca)

Pino‐Figueroa, Alejandro; Nguyen, Diane; Maher, Timothy J.

doi:10.1111/j.1749-6632.2009.05174.x

Cited by 61 publications

(37 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…En ratas se observó que el extracto pentánico presenta una potencial aplicación como neuroprotector en ratas con infarto cerebral por oclusión de la arteria cerebral media (60) . En humanos, la maca reduce los puntajes de depresión y ansiedad en varones adultos aparentemente sanos (7) .…”

Section: Efecto De La Maca Sobre Memoria Depresión Y Ansiedadunclassified

Maca (Lepidium meyenii WALP), una revisión sobre sus propiedades biológicas

Gonzáles

Villaorduña

Gasco

et al. 2014

Rev Peru Med Exp Salud Publica

View full text Add to dashboard Cite

RESUMENLa maca (Lepidium meyenii) es una planta que crece sobre los 4000 metros de altitud en los Andes Centrales del Perú, presenta diferentes variedades de acuerdo al color de su hipocótilo. La presente revisión resume los resultados de estudios sobre los efectos de la maca en la función sexual, la espermatogénesis, la función reproductiva femenina, la memoria, la depresión y la ansiedad, como energizante y contra la hiperplasia benigna de próstata, osteoporosis y síndrome metabólico. Se discute también su efecto antienvejecimiento y la seguridad en su consumo. Se han demostrado diferencias en el efecto de las variedades negra, amarilla y roja de maca. La maca negra es la que mejores resultados presenta sobre la espermatogénesis, la memoria y contra la fatiga, mientras que la maca roja es la variedad que mejor revierte la hiperplasia benigna de próstata y la osteoporosis inducida experimentalmente. Además, la maca reduce los niveles de glucosa, y su consumo se relaciona con la reducción de la presión arterial y un mejor puntaje de salud. Estudios experimentales han demostrado que el consumo a corto como a largo plazo no muestra toxicidad tanto in vivo como in vitro. A pesar que los estudios experimentales han demostrado que la maca presenta diversos efectos benéficos, son necesarios más estudios clínicos para confirmar estos resultados. Palabras clave: Espermatogénesis; Hiperplasia benigna prostática; Osteoporosis; Fatiga; Toxicidad (fuente: DeCS BIREME). MACA (Lepidium meyenii Walp), A REVIEW OF ITS BIOLOGICAL PROPERTIES ABSTRACTMaca (Lepidium meyenii) is a plant that grows above 4000 altitude meters in Peru's Central Andes; it has different varieties according to the color of the hypocotyl. This review summarizes the results of studies about the effects of maca on sexual function, spermatogenesis, female reproductive function, memory, depression and anxiety, and energy as well as effects on benign prostatic hyperplasia, osteoporosis and metabolic syndrome. Its anti-aging effect is also discussed as well as safety in consumption. Differences have been shown between the effects of the black, yellow and red maca varieties. Black maca shows the best results on spermatogenesis, memory and fatigue, while red maca is the variety that reverses the benign prostatic hyperplasia and experimentally induced osteoporosis. In addition, maca reduces the glucose levels, and its consumption is related to the lowering of blood pressure and an improved health score. Experimental studies have proven that short and long term consumption don't show in vivo and in vitro toxicity. Although experimental studies have shown that maca has diverse beneficial effects, more clinical studies are needed to confirm these results.

show abstract

Section: Efecto De La Maca Sobre Memoria Depresión Y Ansiedadunclassified

Maca (Lepidium meyenii WALP), una revisión sobre sus propiedades biológicas

Gonzáles

Villaorduña

Gasco

et al. 2014

Rev Peru Med Exp Salud Publica

View full text Add to dashboard Cite

show abstract

“…Macamides which are lipidsoluble and long-chain, are considered the typical markers for maca, and proved to have several pharmacological properties, such as improving sexual performance and neuroprotective effects (Zheng et al 2000;Pino-Figueroa et al 2010;Vu 2012;Wu et al 2013). In previous experiment, we discovered that maca lipidsoluble extract by petroleum ether extraction could significantly extend the weight-loaded swimming time to exhaustion.…”

Section: Introductionmentioning

confidence: 99%

Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

Yang

Jin

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

Objective: The present study investigates the effects of macamides on endurance capacity and antifatigue property in prolonged swimming mice. Materials and methods: The Balb/c mice were divided into seven groups: a control group, low-dose groups of N-benzyllinoleamide, N-benzyloleamide, and N-benzylpalmitamide, high-dose groups of these macamides. The macamides groups received the commercial products (12 and 40 mg/kg, ig), while the control group received vehicle for 21 d. On the 14th day, the mice were given the weightloaded swimming test. On the 21st day, the mice were sacrificed immediately after 90 min swimming, and some biochemical parameters were measured. Results and discussion: Compared with the control group, exhaustive swimming time was significantly prolonged in high-dose group of N-benzyloleamide (p50.05); the levels of lactic acid (LD), blood ammonia (BA), and lactate dehydrogenase (LDH) were significantly decreased (p50.05), whereas the levels of liver glycogen (LG) and non-esterified fatty acid (NEFA) were significantly increased (p50.05) in high-dose group of N-benzyloleamide. The malondialdehyde (MDA) contents in the brain, muscle, and liver were significantly decreased (p50.05), whereas superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities in the brain, muscle, and liver were significantly increased in high-dose group of N-benzyloleamide (p50.05). Conclusion:The results indicate that N-benzyloleamide has pharmaceutical property against exercise-induced fatigue, and this effect can be explained by the modulated energy metabolism and improved antioxidant status.

show abstract

“…44 In addition, Pino-Figueroa et al recently demonstrated that the lipophilic compounds from maca had potential neuroprotective properties in an in vitro crayfish neuronal cell culture. 45 These findings showed that maca extract prevented ROS damage in the nervous system, thus improving depression.…”

Section: Discussionmentioning

confidence: 77%

Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca (Lepidium meyenii) in Mice Exposed to Chronic Unpredictable Mild Stress

Cheng

et al. 2014

Journal of Medicinal Food

View full text Add to dashboard Cite

Maca has been consumed as a medical food in Peru for thousands of years, and exerts anxiolytic and antidepressant effects. Our present study aimed to evaluate the behavior and anatomical and biochemical effects of petroleum ether extract from maca (ME) in the chronic unpredictable mild stress (CUMS) model of depression in mice. Three different doses of maca extract (125, 250, and 500 mg/kg) were orally administrated in the six-week CUMS procedure. Fluoxetine (10 mg/kg) was used as a positive control drug. Maca extract (250 and 500 mg/kg) significantly decreased the duration of immobility time in the tail suspension test. After treatment with maca extract (250 and 500 mg/kg), the granule cell layer in the dentate gyrus appeared thicker. Maca extract (250 and 500 mg/kg) also induced a significant reduction in corticosterone levels in mouse serum. In mouse brain tissue, after six weeks of treatment, noradrenaline and dopamine levels were increased by maca extract, and the activity of reactive oxygen species was significantly inhibited. Serotonin levels were not significantly altered. These results demonstrated that maca extract (250 and 500 mg/kg) showed antidepressant-like effects and was related to the activation of both noradrenergic and dopaminergic systems, as well as attenuation of oxidative stress in mouse brain.

show abstract

Neuroprotective effects of Lepidium meyenii (Maca)

Cited by 61 publications

References 65 publications

Maca (Lepidium meyenii WALP), una revisión sobre sus propiedades biológicas

Maca (Lepidium meyenii WALP), una revisión sobre sus propiedades biológicas

Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

Antidepressant-Like Behavioral, Anatomical, and Biochemical Effects of Petroleum Ether Extract from Maca (Lepidium meyenii) in Mice Exposed to Chronic Unpredictable Mild Stress

Contact Info

Product

Resources

About