Neuroprotective Effects of Hydrated Fullerene C60: Cortical and Hippocampal EEG Interplay in an Amyloid-Infused Rat Model of Alzheimer's Disease

Vorobyov, Vasily; Kaptsov, Vladimir; Gordon, R. Ya.; Макарова, С. Г.; Podolski, I. Ya.; Sengpiel, Frank

doi:10.3233/jad-142469

Cited by 40 publications

(24 citation statements)

References 65 publications

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“…The design of functional materials for the elaboration of high‐performance supramolecular devices that display specific properties is both a conceptual and synthetic challenge . Within this context, [60]fullerene (C 60 ), an exceptional photophysical and electrochemical unit, generated exciting studies in medicinal (DNA photocleavage, enzyme inhibition, virus inhibition, neuroprotection, antibacterial activity) and materials science (photoactive dyads, triads, polyads, and plastic solar cells). To improve the effectiveness of [60]fullerene‐based devices, materials containing two, three, four, or more C 60 units were synthesized.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Self‐Assembly Behavior of Liquid‐Crystalline Bis‐[60]Fullerodendrimers

Russo

Pieper

Heinrich

et al. 2016

Chemistry A European J

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Bis-[60]fullerodendrimersw ere synthesized by assembling [60]fullerene-containing type I( terminal olefin) and type II (a,b-unsaturatedc arbonyl olefin) olefinst hrough the olefin cross-metathesis reaction. The synthetic modular approach developedi nt his study allowed the preparation of mono-[60]fullerodendrimers and their [60]fullerene-free analogues.F irst-and second-generation poly(aryl ester) dendrons carrying cyanobiphenyl mesogens were used as liquid-crystalline promoters. The liquid-crystallinep roperties were studied by polarized opticalm icroscopy,d ifferential scanningc alorimetry,a nd small-angle X-ray scattering. In agreement with the nature and structure of the dendrimers, nematic, smectic, and multisegregated lamellar phases were observed. Owing to its versatility and tolerance towards many functional groups, olefin cross-metathesis provedt o be ar eaction of choice for the elaboration of molecular materialsw ithcomplex architectures.

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Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Self‐Assembly Behavior of Liquid‐Crystalline Bis‐[60]Fullerodendrimers

Russo

Pieper

Heinrich

et al. 2016

Chemistry A European J

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“…AMPA receptors have been shown to be involved in potentiation of activation of both alpha-secretase and non-amyloidal path of an amyloid precursor (APP) cleavage, i.e., without formation and accumulation of extremely toxic Аβ1-42 [62]. In our previous study, we have revealed С60HyFn-produced inhibition of intracellular Аβ1-42 deposit formation associated with exogenous fibrillar Аβ25-35 [29] and, supposedly, with its endogenous fullerene-disaggregated form [11]. С60HyFn ability to block both intracellular Аβ1-42 generation and the extracellular glutamate receptors activity [63] reducing Ca 2+ inflow, one of the main sources of Аβ25-35 neurotoxicity [64]).…”

Section: Discussionmentioning

confidence: 97%

“…They both converge on single pyramidal cells of the CA1, but affecting them differently. Interestingly, in AD and in its "amyloid-beta" models, early degenerative changes were revealed in CA1 pyramidal neurons [14], [15], [17], [29], [36]. A primary target of Аβ is the EC which, being the main cortical input for the hippocampus, plays a considerable part in memory formation [3], [8], [14], [37].…”

Section: Discussionmentioning

confidence: 99%

“…8, B) the fluorescence was observed only around, rather than inside, the bodies of pyramidal neurons, supposedly, in glia. In contrast, no fluorescence was detected in rats from Saline + Saline and C60HyFn + Аβ25-35 groups with significant decrease of Аβ1-42 deposits in neurons [29]. Thus, accumulation of endogenic Aβ in cytoplasm of СА1 neurons was accompanied by a decreased population of the intact neurons (see Fig.…”

Section: Morphology Of Hippocampal Neuronsmentioning

confidence: 91%

“…In our previous study, we have demonstrated close association between distributions of surviving cells and diffuse Aβ1-42 deposits in neurons [29]. In present study we evaluated the deposits on 12 rats (three animals from each group) aiming to use obtained evidence in peculiar supplemental analysis of the light microscopy results.…”

Section: Immunohistochemical Analysismentioning

confidence: 96%

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Intrahippocampal Pathways Involved in Learning/Memory Mechanisms are Affected by Intracerebral Infusions of Amyloid-β25-35 Peptide and Hydrated Fullerene C60 in Rats

Gordon

Podolski

Макарова

et al. 2017

JAD

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Please note: Changes made as a result of publishing processes such as copy-editing, formatting and page numbers may not be reflected in this version. For the definitive version of this publication, please refer to the published source. You are advised to consult the publisher's version if you wish to cite this paper.This version is being made available in accordance with publisher policies. See http://orca.cf.ac.uk/policies.html for usage policies. Copyright and moral rights for publications made available in ORCA are retained by the copyright holders. known to play a key role in learning and memory mechanisms, it is as yet unclear how its structures are involved in the EC pathology. In this study, changes in memory and neuronal morphology in male Wistar rats intrahippocampally injected with Аβ25-35 were correlated on days 14 and 45 after the injection to reveal specific cognitive -structural associations. The main focus was on the dentate gyrus (DG) and hippocampal areas of CA1 and CA3 because of their involvement in afferent flows from EC to the hippocampus through tri-synaptic (EC  DG  CA3  CA1) and/or mono-synaptic (EC  CA1) pathways. Evident memory impairments were observed at both time points after Аβ25-35 injection. However, on day 14, populations of morphological intact neurons were decreased in CA3 and, drastically, in CA1, and the DG supramedial bundle was significantly damaged. On day 45, this bundle largely and СА1 neurons partially recovered, whereas CA3 neurons remained damaged. We suggest that Аβ25-35 primarily affects the tri-synaptic pathway, destroying the granular cells in the DG supramedial area and neurons in CA3 and, through the Schaffer collaterals, in CA1.Intrahippocampal pretreatment with hydrated fullerene С60 allows the neurons and their connections to survive the amyloidosis, thus supporting the memory mechanisms.

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Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases

Eleftheriadou

Kesidou

Moura

et al. 2020

Small

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dementia, which result from chronic and progressive loss of neuronal function. In view of an ageing population, disorders of the brain are likely to establish the principal economic challenge in the future of healthcare. [1] The total cost of dementia to society in the UK alone is £26.3 billion, and this is expected to double over the next 30 years given that prevalence is projected to rise by 40% in the coming decade alone. [2] Among NDs, significant attention has been paid to Alzheimer's disease (AD) and Parkinson's disease (PD) given their severe complications and economic burdens. AD, which accounts for the vast majority of age-related dementia, is a progressive disorder that is characterized by gradual neuronal loss and accumulation of proteins, namely extracellular amyloid-β plaques and intracellular tau tangles. [3] PD is a progressive ND resulting from the loss of specific dopaminergic (DA) neurons in the substantia nigra pars compacta and reduced DA levels in the nigrostriatal DA pathway in the brain. [4,5] Despite significant progress in the management of NDs over the recent years, the early diagnostic and treatment options remain limited. Patients currently suffering from NDs have no available disease-modifying treatments. Instead, patients are offered a therapeutic plan focused on the management of their ND symptoms, whilst concurrently attempting to reduce the adverse effects associated with the medications used. The systemic delivery of drugs to the central nervous system (CNS) is complex due to their poor delivery to the brain, extensive firstpass metabolism which reduces their half-life, and the sideeffects resulting from the drug acting on non-target peripheral tissues. [6] The mainstay of current treatments for NDs is typically through oral administration. For PD medications include L-dopa, carbidopa (peripheral inhibitor of L-dopa into DOPA), dopaminergic agonists, Entacapone (Catechol-O-methyl transferase inhibitor), monoamine oxidase-B inhibitors, amongst others. Other routes of drug administration exist such as subcutaneous injection of dopaminergic agonists. Interestingly, deep brain stimulation has also been offered to those patients resistant to medical therapy but again associated with significant adverse effects. L-Dopa, which is considered the most effective treatment in the short-term for PD, [7] is related to longterm wearing-off phenomena, dyskinesias, and neuropsychiatric disorders. [8] Redox regulation has recently been proposed as a critical intracellular mechanism affecting cell survival, proliferation, and differentiation. Redox homeostasis has also been implicated in a variety of degenerative neurological disorders such as Parkinson's and Alzheimer's disease. In fact, it is hypothesized that markers of oxidative stress precede pathologic lesions in Alzheimer's disease and other neurodegenerative diseases. Several therapeutic approaches have been suggested so far to improve the endogenous defense against oxidative stress and its harmful effects. Among such approaches, the use o...

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Neuroprotective Effects of Hydrated Fullerene C60: Cortical and Hippocampal EEG Interplay in an Amyloid-Infused Rat Model of Alzheimer's Disease

Cited by 40 publications

References 65 publications

Design, Synthesis, and Self‐Assembly Behavior of Liquid‐Crystalline Bis‐[60]Fullerodendrimers

Design, Synthesis, and Self‐Assembly Behavior of Liquid‐Crystalline Bis‐[60]Fullerodendrimers

Intrahippocampal Pathways Involved in Learning/Memory Mechanisms are Affected by Intracerebral Infusions of Amyloid-β25-35 Peptide and Hydrated Fullerene C60 in Rats

Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases

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