“…In the pilocarpine and kainate models of epilepsy in rodents, a severe episode of SE is essential for the subsequent development of SRS (Goffin et al, 2007;Lemos and Cavalheiro, 1996). By managing the severity of the SE, injecting sub-therapeutic doses of diazepam after the SE onset, one can decrease mortality without decreasing the development of epilepsy (Cunha et al, 2009;Gao et al, 2007;Hellier et al, 1998;Mello et al, 1993;Treiman et al, 1998;Walton and Treiman, 1988). The immediate seizures following pilocarpine injection in marmosets were similar to those described in pilocarpine-treated rodents (Racine et al, 1972;Turski et al, 1983).…”