Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: Behavioral, neurochemical and immunohistochemical studies

Khuwaja, Gulrana; Khan, Mohammad Moshahid; Ishrat, Tauheed; Ahmad, Ajmal; Raza, Syed Shadab; Ashafaq, Mohammad; Javed, Hayate; Khan, M. Badruzzaman; Khan, Andleeb; Vaibhav, Kumar; Safhi, Mohammed M.; Islam, Fakhrul

doi:10.1016/j.brainres.2010.10.023

Cited by 75 publications

(54 citation statements)

References 42 publications

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“…On the other hand, there was an improvement in behavioral activity and antioxidant profile on SA and FA treatment [32]. Our study was in a harmony with other studies, such as quercetin showed neuroprotective effect against MPTP toxication in rats [33] and curcumin also showed neuroprotective effect against 6-hydroxydopamine toxicity [34]. As a well-known fact that the oxidative stress was found to be the main culprit for PD, it is important to evaluate the antioxidant profile of animals.…”

Section: Discussionsupporting

confidence: 86%

Effect of Sesamol in Association With Folic Acid on 6-Ohda Induced Parkinsonian Animals- Biochemical, Neurochemical and Histopathological Evidence

Sereen

Krishnamurthy²,

Nagappan³

et al. 2017

Asian J Pharm Clin Res

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Objective: Parkinson's disease (PD) is the world's second neurodegenerative disorder. Degeneration of dopaminergic neurons is the hallmark of the disease. Here is a novel approach to treat PD with a phenolic compound Sesamol (SA) and in combination with folic acid (FA). Methods:The study was designed with five groups of animals and 6 rats in each group. The rats were infused with 6-hydroxydopamine (10 μg/2 μl in 0.1% ascorbic acid saline) once for the development of PD, Group 1 (control), Group 2 (lesion), Group 3 (lesion+SA), Group 4 (lesion+SA+FA), and Group 5 (lesion+L-dopa). The biochemical parameters such as glucose, triglycerides, protein, FA, thiobarbituric acid reactive substance (TBARS), and antioxidant profile in serum were estimated. The neurotransmitters level in striatum was estimated, and histopathology of striatum and midbrain tissues was carried out. Results:The results showed that 6-hydroxydopamine induced lesion has a significant alteration in the level of glucose, triglycerides, protein and FA, whereas TBARS level was elevated and the activities of antioxidants and neurotransmitters level were reduced. This was significantly restored on SA and FA treatment. The lesion group shows an abnormal architecture of striatum and midbrain, whereas on SA and FA treatment there was minimal abnormality.Conclusion: Thus, our study demonstrates that SA has a neuroprotective effect against 6-hydroxydopamine insult and showed a synergic effect when combined with FA.

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Section: Discussionsupporting

confidence: 86%

Effect of Sesamol in Association With Folic Acid on 6-Ohda Induced Parkinsonian Animals- Biochemical, Neurochemical and Histopathological Evidence

Sereen

Krishnamurthy²,

Nagappan³

et al. 2017

Asian J Pharm Clin Res

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“…[44] CM, the active principle of turmeric used in Indian curry is known for antioxidant, antiarthritic, anti-ischemic and anti-inflammatory properties [ Table 1]. [45] It is used as a food-coloring agent and easily available for medication. CM shows antiarthritic, antiamyloid, antioxidant, and anti-inflammatory properties.…”

Section: Ayurvedic Medicinesmentioning

confidence: 99%

“…[47] CM is also used in various systems of indigenous medicine and is helpful in preventing arthritis and has therapeutic potential in combating RA disorder [ Table 1]. [45] Infusions of BTI, produced significant inhibition of rat paw edema, induced with carrageenin (pre-and post-treatment) and arachidonic acid if administered orally. BTI was also found to inhibit peritoneal capillary permeability and caused a marked reduction of LPS induced PGE2 generation.…”

Section: Ayurvedic Medicinesmentioning

confidence: 99%

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Upadhyay

2016

IJGP

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The present review explains reasons of arthritis a disease related to chronic joint pain and inflammation. It also emphasizes the use of bioactive principles of plant origin to be used to relieve from arthritic pain, aching, stiffness, and swelling. These plant natural products can finish rheumatic pain if they are used regularly according to physician' advice. There are so many active crude extracts and pure compounds which show anti-arthritic activity in Freund's complete adjuvant induced animal models. Certain Ayurvedic formulations also assist to relieve from rheumatic arthritic pain and tone up immune system to function normally. This article shows an overview of medicinal suggestions on the basis of experimental advances made in the herbal medicinal researches in recent years for the treatment of arthritis. There are various dietary supplements which could also provide for management of severe pain of joints, and mitigation of inflammation. It is also suggested that early diagnosis, proper treatment, and healthy dietary habits can reduce the disease spectrum and chronic inflammatory pain.

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“…A total of six studies were identified in the systematic review [155][156][157][158][159][160]. Curcumin (3 x 50 m/kg) was investigated for the first time by Vajragupta et al, [158] using the MPTP injury model in mice.…”

Section: Curcumin (Supplementary Materials Table A5)mentioning

confidence: 99%

“…Moreover, they showed that curcumin was also able to inhibit the c-Jun N-terminal kinase (JNK) pathway, suggesting that its neuroprotective effect is not only due to its antioxidant properties. Recently, another investigation by Khuwaja et al, [155] demonstrated the neuroprotective effects of pretreatment with curcumin in the 6-OHDA model in rats. Both motor deficits and neuronal damage were prevented by curcumin, which also had beneficial effects on the antioxidant status, with increasing GSH levels and activity of antioxidant enzymes.…”

Section: Curcumin (Supplementary Materials Table A5)mentioning

confidence: 99%

Neuroprotection in Parkinson's Disease: A Systematic Review of the Preclinical Data

Douna¹,

Bavelaar²,

Pellikaan³

et al. 2012

TOPHARMJ

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Abstract:Aim: This study aimed to systematically review the preclinical data of neuroprotective agents for Parkinson's disease (PD) to support the translation of these compounds. Methods:The study consisted of two phases. In phase I, Pubmed and Scopus were systematically searched for neuroprotective agents for PD. In phase II, a systematic search was conducted for each substance identified in phase I. Articles were included if they used MPTP, 6-OHDA, rotenone or paraquat injury models.Results: Phase I led to the identification of 168 putative neuroprotective agents. Eventually ten compounds were included: melatonin, estrogen, nicotine, caffeine, riluzole, curcumin, coenzyme Q10, aspirin, EGCG and resveratrol. Phase II revealed 113 experimental studies and three reviews. Conclusion:This study clearly depicts the preclinical data of ten promising neuroprotective agents. While some of these compounds have already been tested in clinical use, none of them was studied in an appropriately designed trial to determine a neuroprotective effect. In expectation of qualitatively improved neuroprotection trials, the data from this study provide a firm foundation for future research.

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Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: Behavioral, neurochemical and immunohistochemical studies

Cited by 75 publications

References 42 publications

Effect of Sesamol in Association With Folic Acid on 6-Ohda Induced Parkinsonian Animals- Biochemical, Neurochemical and Histopathological Evidence

Effect of Sesamol in Association With Folic Acid on 6-Ohda Induced Parkinsonian Animals- Biochemical, Neurochemical and Histopathological Evidence

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Neuroprotection in Parkinson's Disease: A Systematic Review of the Preclinical Data

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