Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX-2, TGF-β1/2, MMP-9 and BDNF in a rat model

Hu, Yuan; Tang, Jinshu; Hou, Shuxun; Shi, Xiuxiu; Jiang, Qin; Zhang, Tiesong; Wang, Xiao‐Jing

doi:10.3892/mmr.2017.7464

Cited by 16 publications

(10 citation statements)

References 23 publications

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“…In spine instability mouse models, Bian Q et al 10,103 observed that aberrant mechanical loading could lead to the excessive activation of TGF-b signaling and IVD degeneration, and administration of TbRI (ALK5) inhibitor suppressed the R-SMAD signaling and attenuated the IVD degeneration. And in a rabbit annular puncture model, Hu Y et al 105 found that halofuginone could delay the IVD degeneration and the inactivation of TGF-b signaling might be involved. Furthermore, the study of Kwon YJ et al 106 suggested that TGF-b1 was increased and could activate both SMAD2/3 and SMAD1/5/8 pathways in bovine NPCs under degenerative condition, and the activated SMAD1/5/8 pathway could negatively regulate the SMAD2/3 signaling, which resulted in further IVD degeneration.…”

Section: Excessive Activation Of Tgf-b Signaling May Contribute To IVmentioning

confidence: 99%

TGF-β signaling in intervertebral disc health and disease

Chen

Liu

et al. 2019

Osteoarthritis and Cartilage

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Objective: This paper aims to provide a comprehensive review of the changing role of transforming growth factor-b (TGF-b) signaling in intervertebral disc (IVD) health and disease. Methods: A comprehensive literature search was performed using PubMed terms 'TGF-b' and 'IVD'. Results: TGF-b signaling is necessary for the development and growth of IVD, and can play a protective role in the restoration of IVD tissues by stimulating matrix synthesis, inhibiting matrix catabolism, inflammatory response and cell loss. However, excessive activation of TGF-b signaling is detrimental to the IVD, and inhibition of the aberrant TGF-b signaling can delay IVD degeneration. Conclusions: Activation of TGF-b signaling has a promising treatment prospect for IVD degeneration, while excessive activation of TGF-b signaling may contribute to the progression of IVD degeneration. Studies aimed at elucidating the changing role of TGF-b signaling in IVD at different pathophysiological stages and its specific molecular mechanisms are needed, and these studies will contribute to safe and effective TGF-b signaling-based treatments for IVD degeneration.

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Section: Excessive Activation Of Tgf-b Signaling May Contribute To IVmentioning

confidence: 99%

TGF-β signaling in intervertebral disc health and disease

Chen

Liu

et al. 2019

Osteoarthritis and Cartilage

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“…In respect to its high incidence rate, finding treatments for LIDD is of importance. Increasing evidence demonstrates that TGF-β has dual role in different disorders, so that it may reduce the number of cells undergoing apoptosis in a certain circumstance, while it may enhance apoptotic cell death (Hu et al, 2017). Curcumin administration alleviates LIDD by inhibition of TGF-β1 and TGF-β2 signaling pathways.…”

Section: Neurological Disordersmentioning

confidence: 99%

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

et al. 2020

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Immune response, proliferation, migration and angiogenesis are juts a few of cellular events that are regulated by transforming growth factor-β (TGF-β) in cells. A number of studies have documented that TGF-β undergoes abnormal expression in different diseases, e.g., diabetes, cancer, fibrosis, asthma, arthritis, among others. This has led to great fascination into this signaling pathway and developing agents with modulatory impact on TGF-β. Curcumin, a natural-based compound, is obtained from rhizome and roots of turmeric plant. It has a number of pharmacological activities including antioxidant, anti-inflammatory, anti-tumor, anti-diabetes and so on. Noteworthy, it has been demonstrated that curcumin affects different molecular signaling pathways such as Wnt/β-catenin, Nrf2, AMPK, mitogen-activated protein kinase and so on. In the present review, we evaluate the potential of curcumin in regulation of TGF-β signaling pathway to corelate it with therapeutic impacts of curcumin. By modulation of TGF-β (both upregulation and down-regulation), curcumin ameliorates fibrosis, neurological disorders, liver disease, diabetes and asthma. Besides, curcumin targets TGF-β signaling pathway which is capable of suppressing proliferation of tumor cells and invading cancer cells.

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“…Some studies suggested that the reduction of TGF-β1 leading decline of anabolic synthesis was the main cause of disc degeneration [ 1 , 3 , 26 ]. However, recent studies have shown that the expression of TGF-β1 in degenerative disc tissues was significantly increased [ 8 , 24 ], local excessively high concentration of TGF-β might accelerate the disc degeneration [ 15 , 29 ]. Additionally, abnormal expression of TGF-β might also lead to the decrease of type II collagen and the increase of type I collagen [ 4 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Histological Changes of Cervical Disc Tissue in Patients with Degenerative Ossification

Xiong

Yang

Gao

et al. 2022

J Korean Neurosurg Soc

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Objective : To explore the histological feature of the cervical disc degeneration in patients with degenerative ossification (DO) and its potential mechanisms. Methods : A total of 96 surgical segments, from cervical disc degenerative disease patients with surgical treatment, were divided into ossification group (group O, n=46) and non-ossification group (group NO, n=50) based on preoperative radiological exams. Samples of disc tissues and osteophytes were harvested during the decompression operation. The hematoxylin-eosin staining, Masson trichrome staining and Safranin O-fast green staining were used to compare the histological differences between the two groups. And the distribution and content of transforming growth factor (TGF)-β1, p-Smad2 and p-Smad3 between the two groups were compared by a semi-quantitative immunohistochemistry (IHC) method.Results : For all the disc tissues, the content of disc cells and collagen fibers decreased gradually from the outer annulus fibrosus (OAF) to the central nucleus pulposus (NP). Compared with group NO, the number of disc cells in group O increased significantly. But for proteoglycan in the inner annulus fibrosus (IAF) and NP, the content in group O decreased significantly. IHC analysis showed that TGF-β1, p-Smad2, and p-Smad3 were detected in all tissues. For group O, the content of TGF-β1 in the OAF and NP was significantly higher than that in group NO. For p-Smad2 in IAF and p-Smad3 in OAF, the content in group O were significantly higher than group NO. Conclusion : Histologically, cervical disc degeneration in patients with DO is more severe than that without DO. Local higher content of TGF-β1, p-Smad2, and p-Smad3 are involved in the disc degeneration with DO. Further studies with multi-approach analyses are needed to better understand the role of TGF-β/Smads signaling pathway in the disc degeneration with DO.

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Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX-2, TGF-β1/2, MMP-9 and BDNF in a rat model

Cited by 16 publications

References 23 publications

TGF-β signaling in intervertebral disc health and disease

TGF-β signaling in intervertebral disc health and disease

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

Histological Changes of Cervical Disc Tissue in Patients with Degenerative Ossification

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