Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB, IκKB, and p53 genes in male Wistar rats

Josiah, Sunday Solomon; Famusiwa, Courage Dele; Crown, Olamide O.; Lawal, Akeem O.; Olaleye, Mary Tolulope; Akindahunsi, A. A.; Akinmoladun, Afolabi Clement

doi:10.1016/j.neuro.2022.03.004

Cited by 27 publications

(14 citation statements)

References 91 publications

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“…Sharma et al (2020) and Jain et al (2022) investigated the effects of quercetin on rotenone-induced neuroinflammation and alterations in mice behavior [ 56 , 57 ]. Josiah et al (2022) examined the effects of catechin and quercetin on dopamine metabolism and gene expression in male Wistar rats [ 58 ]. Ay et al (2017) investigated the molecular mechanisms underlying the protective effects of quercetin against mitochondrial dysfunction and dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of PD [ 59 ].…”

Section: Natural Products and Neuroprotection And Neuroinflammationmentioning

confidence: 99%

The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms

Chiang

Tsai

Wang

2023

IJMS

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Neuroinflammation is a critical factor in developing and progressing numerous brain diseases, including neurodegenerative diseases. Chronic or excessive neuroinflammation can lead to neurotoxicity, causing brain damage and contributing to the onset and progression of various brain diseases. Therefore, understanding neuroinflammation mechanisms and developing strategies to control them is crucial for treating brain diseases. Studies have shown that neuroinflammation plays a vital role in the progression of neurodegenerative diseases, such as Alzheimer’s (AD) and Parkinson’s (PD), and stroke. Additionally, the effects of PM2.5 pollution on the brain, including neuroinflammation and neurotoxicity, are well-documented. Quercetin is a flavonoid, a plant pigment in many fruits, vegetables, and grains. Quercetin has been studied for its potential health benefits, including its anti-inflammatory, antioxidant, and anti-cancer properties. Quercetin may also have a positive impact on immune function and allergy symptoms. In addition, quercetin has been shown to have anti-inflammatory and neuroprotective properties and can activate AMP-activated protein kinase (AMPK), a cellular energy sensor that modulates inflammation and oxidative stress. By reducing inflammation and protecting against neuroinflammatory toxicity, quercetin holds promise as a safe and effective adjunctive therapy for treating neurodegenerative diseases and other brain disorders. Understanding and controlling the mechanisms of NF-κB and NLRP3 inflammasome pathways are crucial for preventing and treating conditions, and quercetin may be a promising tool in this effort. This review article aims to discuss the role of neuroinflammation in the development and progression of various brain disorders, including neurodegenerative diseases and stroke, and the impact of PM2.5 pollution on the brain. The paper also highlights quercetin’s potential health benefits and anti-inflammatory and neuroprotective properties.

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Section: Natural Products and Neuroprotection And Neuroinflammationmentioning

confidence: 99%

The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms

Chiang

Tsai

Wang

2023

IJMS

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“…47 Other flavonoids such as quercetin and catechin possess neuroprotective potential by ameliorating redox stress and modulating antiapoptotic pathways. 48 Spinasterol was shown to produce HO-1 in mouse hippocampal HT22 and BV2 microglial cells. 49 Quercetin-3-rutinoside exhibits the attenuation of neuroinflammation and oxidative stress in the spinal cord.…”

Section: Discussionmentioning

confidence: 98%

“…Among the flavonoids, kaempferol possesses good activity in all three antioxidant model systems. The major biological activities of kaempferol-3- O -β- d -glucuronide reported so far include antioxidant, , rat lens aldose inhibition, anti-inflammatory, and antiHIV activities. K3G has been reported to exhibit anti-inflammatory effects in LPS-stimulated RAW264.7 cells and mice models .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, kaempferol glycosides have an antineuroprotective effect against neuroinflammation by inhibiting NF-κB and STAT3 . Other flavonoids such as quercetin and catechin possess neuroprotective potential by ameliorating redox stress and modulating antiapoptotic pathways . Spinasterol was shown to produce HO-1 in mouse hippocampal HT22 and BV2 microglial cells .…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant and Antineuroinflammatory Mechanisms of Kaempferol-3-O-β-d-Glucuronate on Lipopolysaccharide-Stimulated BV2 Microglial Cells through the Nrf2/HO-1 Signaling Cascade and MAPK/NF-κB Pathway

Lim

Prajapati

Seong³

et al. 2023

ACS Omega

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Aglycone-and glycoside-derived forms of flavonoids exist broadly in plants and foods such as fruits, vegetables, and peanuts. However, most studies focus on the bioavailability of flavonoid aglycone rather than its glycosylated form. Kaempferol-3-O-β-D-glucuronate (K3G) is a natural flavonoid glycoside obtained from various plants that have several biological activities, including antioxidant and anti-inflammatory effects. However, the molecular mechanism related to the antioxidant and antineuroinflammatory activity of K3G has not yet been demonstrated. The present study was designed to demonstrate the antioxidant and antineuroinflammatory effect of K3G against lipopolysaccharide (LPS)stimulated BV2 microglial cells and to evaluate the underlying mechanism. Cell viability was determined by MTT assay. The inhibition rate of reactive oxygen species (ROS) and the production of pro-inflammatory mediators and cytokines were measured by DCF-DA assay, Griess assay, enzyme-linked immunosorbent assay (ELISA), and western blotting. K3G inhibited the LPS-induced release of nitric oxide, interleukin (IL)-6, and tumor necrosis factor-α (TNF-α) as well as the expression of prostaglandin E synthase 2. Additionally, K3G reduced the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor-kappa B (NF-κB) related proteins. Mechanistic studies found that K3G downregulated phosphorylated mitogen-activated protein kinases (MAPKs) and upregulated the Nrf2/HO-1 signaling cascade. In this study, we demonstrated the effects of K3G on antineuroinflammation by inactivating phosphorylation of MPAKs and on antioxidants by upregulating the Nrf2/HO-1 signaling pathway through decreasing ROS in LPS-stimulated BV2 cells.

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“…In another investigation by Josiah et al, the animal studies observed the promising efficacy of quercetin on NF-κB and IκKB gene expressions compared to the rotenone group only. Different research data have exhibited the potential of quercetin for PD by relieving oxidative stress, observing dopaminergic breakdown, and altering neuroinflammation, along with apoptosis ( Josiah et al, 2022 ).…”

Section: Phytoconstituents In Different Neurological Disordersmentioning

confidence: 99%

Natural product-based pharmacological studies for neurological disorders

Puri

Kanojia²,

Sharma³

et al. 2022

Front. Pharmacol.

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Central nervous system (CNS) disorders and diseases are expected to rise sharply in the coming years, partly because of the world’s aging population. Medicines for the treatment of the CNS have not been successfully made. Inadequate knowledge about the brain, pharmacokinetic and dynamic errors in preclinical studies, challenges with clinical trial design, complexity and variety of human brain illnesses, and variations in species are some potential scenarios. Neurodegenerative diseases (NDDs) are multifaceted and lack identifiable etiological components, and the drugs developed to treat them did not meet the requirements of those who anticipated treatments. Therefore, there is a great demand for safe and effective natural therapeutic adjuvants. For the treatment of NDDs and other memory-related problems, many herbal and natural items have been used in the Ayurvedic medical system. Anxiety, depression, Parkinson’s, and Alzheimer’s diseases (AD), as well as a plethora of other neuropsychiatric disorders, may benefit from the use of plant and food-derived chemicals that have antidepressant or antiepileptic properties. We have summarized the present level of knowledge about natural products based on topological evidence, bioinformatics analysis, and translational research in this review. We have also highlighted some clinical research or investigation that will help us select natural products for the treatment of neurological conditions. In the present review, we have explored the potential efficacy of phytoconstituents against neurological diseases. Various evidence-based studies and extensive recent investigations have been included, which will help pharmacologists reduce the progression of neuronal disease.

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Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB, IκKB, and p53 genes in male Wistar rats

Cited by 27 publications

References 91 publications

The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms

The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms

Antioxidant and Antineuroinflammatory Mechanisms of Kaempferol-3-O-β-d-Glucuronate on Lipopolysaccharide-Stimulated BV2 Microglial Cells through the Nrf2/HO-1 Signaling Cascade and MAPK/NF-κB Pathway

Natural product-based pharmacological studies for neurological disorders

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