2016
DOI: 10.1038/srep31450
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Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease

Abstract: Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex disease pathogenesis. The plant polyphenol apigenin has been shown to have anti-inflammatory and neuroprotective properties in a number of cell and animal models; however a comprehensive assessment has not been performed in a human model of AD. Here we have used a human induced pluripotent stem cell (iPSC) model of familial and sporadic AD, in addition to healthy … Show more

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Cited by 211 publications
(135 citation statements)
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“…Apigenin (4′,5,6‐trihydroxyflavone) extracted from various fruits and vegetables, including parsley, apples, and grapes, is a potential therapeutic agents against diverse diseases such as diabetes (Panda & Kar, ), cardiovascular diseases (Buwa, Mahajan, Patil, & Goyal, ), neuronal diseases (Balez et al, ), metabolic diseases (Feng et al, ), and cancers (Shukla & Gupta, ). To prevent or inhibit progression of those diseases, apigenin regulates a variety of intracellular signal transduction pathways.…”
Section: Introductionmentioning
confidence: 99%
“…Apigenin (4′,5,6‐trihydroxyflavone) extracted from various fruits and vegetables, including parsley, apples, and grapes, is a potential therapeutic agents against diverse diseases such as diabetes (Panda & Kar, ), cardiovascular diseases (Buwa, Mahajan, Patil, & Goyal, ), neuronal diseases (Balez et al, ), metabolic diseases (Feng et al, ), and cancers (Shukla & Gupta, ). To prevent or inhibit progression of those diseases, apigenin regulates a variety of intracellular signal transduction pathways.…”
Section: Introductionmentioning
confidence: 99%
“…Neuronal cell death is closely associated with apoptosis, and many apoptosis factors can be observed in neurodegenerative disease. Previous studies have reported that inhibition of apoptosis can help protect damaged neuronal cells (Balez et al., ; Chuang et al., ; Wu et al., ). Neuroprotective effects related to apoptosis are commonly demonstrated using PI or Hoechst 33342 staining, Annexin V/PI staining, immunochemistry, calcium concentration, and western blot.…”
Section: Determination Of Neuroprotective Effect Of Peptides/hydrolysmentioning
confidence: 99%
“…However, the overactivation of microglia may lead to the pathogenesis and aggravation of CNS damage in inflammatory diseases including multiple sclerosis (MS) (35). MS is recognized as a chronic inflammatory autoimmune disorder featuring CNS demyelination and neurodegeneration (6, 7).…”
Section: Introductionmentioning
confidence: 99%