Neuroprotective effects associated with immune modulation by selected lactic acid bacteria in a Parkinson's disease model

Visñuk, Daiana Perez; Giori, Graciela Savoy de; LeBlanc, Jean Guy; LeBlanc, Alejandra de Moreno de

doi:10.1016/j.nut.2020.110995

Cited by 40 publications

(67 citation statements)

References 38 publications

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“…Previous research has also proven the neuroprotective effects of Lactobacillus administration in MPTP- and rotenone-induced PD models as well as PD patients ( Liao et al., 2020 ; Ilie et al., 2021 ; Lu et al., 2021 ). In agreement with our results, Lactobacillus was previously reported to attenuate MPTP-induced neuroinflammation by preventing glial hyperactivation, and inhibiting the levels of TNF-α , and IL-6 ( Liao et al., 2020 ; Perez Visñuk et al., 2020 ). Intriguingly, Lactobacillus -based probiotics increased the levels of both dopamine and serotonin in the striatum, thus ameliorating the anxiety-like behavior of germ-free mice ( Liu WH et al., 2016 ).…”

Section: Discussionsupporting

confidence: 93%

Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson’s disease

Cui

Han

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundParkinson’s disease (PD) is a common neurodegenerative disorder, accompanied by motor deficits as well as gastrointestinal dysfunctions. Recent studies have proved that the disturbance of gut microbiota and metabolism contributes to the pathogenesis of PD; however, the mechanisms underlying these effects have yet to be elucidated. Curcumin (CUR) has been reported to provide neuroprotective effects on neurological disorders and modulate the gut flora in intestinal-related diseases. Therefore, it is of significant interest to investigate whether CUR could exert a protective effect on PD and whether the effect of CUR is dependent on the intestinal flora and subsequent changes in metabolites.MethodsIn this study, we investigated the neuroprotective effects of CUR on a mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). 16S rRNA sequencing was performed to explore the profile of the gut microbiota among controls, MPTP-treated mice and CUR-treated mice. Then, antibiotic treatment (ABX) and fecal microbiota transplantation (FMT) experiments were conducted to examine the role of intestinal microbes on the protective effects of CUR in PD mice. Furthermore, ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS)-based metabolomics analysis was used to identify the landscape of the CUR-driven serum metabolome. Finally, Pearson’s analysis was conducted to investigate correlations between the gut flora-metabolite axis and CUR-driven neuroprotection in PD.ResultsOur results showed that CUR intervention effectively improved motor deficits, glial cell activation, and the aggregation of α-synuclein (α-syn) in MPTP-treated mice. 16S rRNA sequencing showed elevated abundances of Muribaculaceae, Lactobacillaceae, Lachnospiraceae and Eggerthellaceae but depleted abundances of Aerococcaceae and Staphylococcaceae in CUR-treated mice when compared with MPTP mice. ABX and FMT experiments further confirmed that the gut microbiota was required for CUR-induced protection in PD mice. Serum metabolomics analysis showed that CUR notably upregulated the levels of tyrosine, methionine, sarcosine and creatine. Importantly, strong correlations were identified among crucial taxa (Aerococcaceae, Staphylococcaceae, Muribaculaceae, Lactobacillaceae, Lachnospiraceae and Eggerthellaceae), pivotal metabolites (tyrosine, methionine, sarcosine and creatine) and the motor function and pathological results of mice. CUR treatment led to a rapid increase in the brain levels of tyrosine and levodopa (dopa) these changes were related to the abundances of Lactobacillaceae and Aerococcaceae.ConclusionsCUR exerts a protective effect on the progression of PD by modulating the gut microbiota-metabolite axis. Lactobacillaceae and Aerococcaceae, along with key metabolites such as tyrosine and dopa play a dominant role in CUR-associated neuroprotection in PD mice. Our findings offer unique insights into the pathogenesis and potential treatment of PD.

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Section: Discussionsupporting

confidence: 93%

Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson’s disease

Cui

Han

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Of interest, hyperhomocysteinemia is associated with neuroinflammation in a murine model of vascular dementia (87). The use of folate-producing probiotic strains can be useful in reduction of neuroinflammation, as indicated by decreased levels of pro-inflammatory cytokines, and by improvement of motor behavior in PD (88). Some RCTs suggest that treatment with folate and vitamin B12 could be helpful in the long-term management of specific populations affected by depressive symptoms.…”

Section: Focus On Folic Acid and Neuroinflammationmentioning

confidence: 99%

The Impact of Nutrients on Mental Health and Well-Being: Insights From the Literature

Muscaritoli

2021

Front. Nutr.

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A good nutritional status is important for maintaining normal body function and preventing or mitigating the dysfunction induced by internal or external factors. Nutritional deficiencies often result in impaired function, and, conversely, intakes at recommended levels can resume or further enhance body functions. An increasing number of studies are revealing that diet and nutrition are critical not only for physiology and body composition, but also have significant effects on mood and mental well-being. In particular, Western dietary habits have been the object of several research studies focusing on the relationship between nutrition and mental health. This review aims to summarize the current knowledge about the relationship between the intake of specific micro- and macronutrients, including eicosapentaenoic acid, docosahexaenoic acid, alpha-tocopherol, magnesium and folic acid, and mental health, with particular reference to their beneficial effect on stress, sleep disorders, anxiety, mild cognitive impairment, as well as on neuropsychiatric disorders, all significantly affecting the quality of life of an increasing number of people. Overall data support a positive role for the nutrients mentioned above in the preservation of normal brain function and mental well-being, also through the control of neuroinflammation, and encourage their integration in a well-balanced and varied diet, accompanied by a healthy lifestyle. This strategy is of particular importance when considering the global human aging and that the brain suffers significantly from the life-long impact of stress factors.

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“…Caroline Xie et al showed that probiotics ameliorated hippocampal-dependent cognitive deficits in preclinical PD models (Xie and Prasad, 2020). Perez Visnuk et al showed that decreased levels of inflammatory cytokines IL-6 and TNF-α in serum and increased levels of antiinflammatory cytokines IL-10 in serum and brain tissue in the probiotic-treated PD mice (Perez Visñuk et al, 2020). A study by Athari Nik Azm et al showed that probiotics reduced oxidative stress biomarkers and amyloid plaque formation in mice (Athari Nik Azm et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Probiotics for the Treatment of Alzheimer's Disease, Mild Cognitive Impairment, and Parkinson's Disease: A Systematic Review and Meta-Analysis

Xiang

et al. 2022

Front. Aging Neurosci.

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BackgroundAlzheimer's disease (AD) and Parkinson's disease (PD) are two of the most common neurodegenerative diseases, and mild cognitive impairment (MCI) is considered a prodromal stage of clinical AD. Animal studies have shown that probiotics can improve cognitive function and mitigate inflammatory response, however, results from randomized controlled trials in humans are still unclear.ObjectivesA systematic review and meta-analysis was conducted to evaluate the efficacy and safety of probiotic therapy on cognitive function, oxidative stress, and gastrointestinal function in patients with AD, MCI, and PD.MethodsWe searched the electronic databases such as PubMed, EMBASE, Cochrane Library until October 2020 for the eligible randomized controlled trials, as well as the unpublished and ongoing trials. Our primary endpoints were cognitive function, inflammatory and oxidative stress biomarkers, gastrointestinal function, and adverse events.ResultsAfter screening 2,459 titles and abstracts about AD or MCI, we selected 6 eligible studies (n = 499 patients). After screening 1,923 titles and abstracts about PD, we selected 5 eligible studies (n = 342 patients). Compared with the control group, treatment with probiotics improved the cognitive function of patients with AD in the intervention group (P = 0.023). Cognitive function also improved in MCI patients (P = 0.000). Inflammation-related indicators: Malondialdehyde (MDA) was significantly reduced (P = 0.000); and hs-CRP decreased (P = 0.003). Lipid-related indicators: VLDL decreased (P = 0.026); triglyceride decreased (P = 0.009); and insulin resistance level improved: decreased Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (P = 0.019).ConclusionOur analyses suggest that probiotics can improve cognitive and gastrointestinal symptoms in patients with AD, MCI, and PD, which is possibly through reducing inflammatory response and improving lipid metabolism. The safety has also been proven. However, more RCTs with rigorous study design are needed to support our findings.Systematic Review RegistrationPROSPERO, Identifier: CRD42021231502.

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Neuroprotective effects associated with immune modulation by selected lactic acid bacteria in a Parkinson's disease model

Abstract: Neuroprotective effects associated to immune modulation by selected lactic acid bacteria in a Parkinson's disease model, Nutrition (2020), doi:

Cited by 40 publications

References 38 publications

Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson’s disease

Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson’s disease

The Impact of Nutrients on Mental Health and Well-Being: Insights From the Literature

Efficacy and Safety of Probiotics for the Treatment of Alzheimer's Disease, Mild Cognitive Impairment, and Parkinson's Disease: A Systematic Review and Meta-Analysis

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