Neuroprotective Effect of the Novel Na+/Ca2+ Channel Blocker NS-7 on Rat Retinal Ganglion Cells

Saito, Shinichiro; Ohashi, Megumi; Naito, Akira; Fukaya, Yasuhiro; Suzuki, Yoshiyuki; Araie, Makoto

doi:10.1007/s10384-005-0210-3

Cited by 8 publications

(4 citation statements)

References 38 publications

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“…22 This potential neuroprotective effect of flunarizine has been studied in a variety of experimental models, including ischemia-reperfusion models in rabbits, 3 rats, 33 sheep, 17 and gerbils 21 ; in sciatic 20 and optic 19 nerve axotomy in rats; and in a model of light-mediated injury to the rat retina. 18 Calcium antagonists have also been reported to be neuroprotective in ischemia-reperfusion models in vivo 34,35 and in excitotoxicity models in which retinal ganglion cells and cortical neurons in cell culture were exposed to N-methyl-D-aspartate and glutamate 3,35 or in which nerve growth factor was withdrawn. 20 In addition, the effect of this class of agents on vascular smooth muscle could contribute to the improvement in optic nerve head or retinal blood flow measured in normal subjects and in patients with glaucoma after treatment with calcium channel blockers, 9,15,16,28 and to the improvement in visual field parameters observed in patients with normal tension glaucoma.…”

Section: Discussionmentioning

confidence: 98%

Effect of Flunarizine, a Calcium Channel Blocker, on Intraocular Pressure and Aqueous Humor Dynamics in Monkeys

Wang

Gagliuso

Podos³

2008

Journal of Glaucoma

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Section: Discussionmentioning

confidence: 98%

Effect of Flunarizine, a Calcium Channel Blocker, on Intraocular Pressure and Aqueous Humor Dynamics in Monkeys

Wang

Gagliuso

Podos³

2008

Journal of Glaucoma

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“…The study showed that orally delivered phenytoin was effective in protecting neurons. Saito et al investigated whether NS-7 (4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy) pyrimidine hydrochloride [ 55 ], a novel Na + /Ca 2+ channel blocker, can protect the rat retina. They showed that NS-7 has neuroprotective effects against retinal damage resulting from subjection to ischemia.…”

Section: Trace Elements In Glaucomamentioning

confidence: 99%

Influence of Trace Elements on Neurodegenerative Diseases of The Eye—The Glaucoma Model

Kamińska

Romano

Ręjdak

et al. 2021

IJMS

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Glaucoma is a heterogeneous group of chronic neurodegenerative disorders characterized by a relatively selective, progressive damage to the retinal ganglion cells (RGCs) and their axons, which leads to axon loss and visual field alterations. To date, many studies have shown the role of various elements, mainly metals, in maintaining the balance of prooxidative and antioxidative processes, regulation of fluid and ion flow through cell membranes of the ocular tissues. Based on the earlier and current research results, their relationship with the development and progression of glaucoma seems obvious and is increasingly appreciated. In this review, we aimed to summarize the current evidence on the role of trace elements in the pathogenesis and prevention of glaucomatous diseases. Special attention is also paid to the genetic background associated with glaucoma-related abnormalities of physiological processes that regulate or involve the ions of elements considered as trace elements necessary for the functioning of the cells.

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“…[6] The thickness of twelve areas of each retinal specimen was measured beginning from the optic disc in the center and moving peripherally in increments of 250 µm in 2 opposite ways, dorsally and ventrally, which included central and peripheral retina. The average measured values of the IPL/ONL ratio from twelve measurements of each eye were used to evaluate the extent of ischemia-reperfusion damage of retina [25].…”

Section: Histopathologymentioning

confidence: 99%

The neuroprotective effect of submicron and blended <i>Lycium barbarum</i> for experiment retinal ischemia and reperfusion injury in rats

Chan

Lin

2020

J. Vet. Med. Sci.

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The purpose of this study was to investigate the neuroprotective potential of submicron (milled) and blended Lycium barbarum (LB) in glaucomatous retinal neuropathy using a rat model of high intraocular pressure (HIOP) induced retinal ischemia. The rats were treated with 500, 250, 100 mg/kg LB (submicron or blended form) orally once daily for 56 days respectively after 1 week of retinal ischemia induction. We conducted electroretinography (ERG), histopathological analysis in retina and antioxidative level assays, such as total glutathione (GSH (glutathione) + reduced glutathione) + GSSH (glutathione disulfide), catalase activity, SOD (superoxide dismutase) activity, and lipid peroxidant malondialdehyde (MDA) in the retina and plasma of test rats. The results indicated that the amplitudes of a and b wave of ERG were preserved in rats treated with submicron and blended LB groups, the best protective effect on ERG b wave amplitudes was observed at the dosage of 250 mg/kg of both forms of LB. Retinal thickness was best preserved, particularly significant in the retinal inner nuclear layer in submicron 250 mg/kg LB group. The levels of antioxidant GSSH+GSH, SOD and catalase activity in the retina were higher in blended 500 mg/kg and submicron 250 mg/kg groups than other groups, while the MDA level was lower in submicron LB groups than that in blended LB and non-LB IR group. In the plasma, there was no significant difference in the levels of GSSH+GSH and catalase activity between treated groups, but higher levels of SOD and lower levels of MDA were observed in 250 mg/kg submicron and 500 mg/kg submicron LB groups than the blended LB and non-LB IR groups. Generally better antioxidative effects were observed in the submicron LB than blended LB among treated groups, especially the 250 mg/kg submicron LB, providing good retinal neuroprotection by preserving retinal structure and function with improved antioxidative capacity. The submicron LB may have clinical implication as an adjuvant therapy of oxidative stress and retinal damage caused by HIOP induced retinal ischemia and reperfusion injury.

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Neuroprotective Effect of the Novel Na+/Ca2+ Channel Blocker NS-7 on Rat Retinal Ganglion Cells

Abstract: NS-7 has neuroprotective effects against retinal damage resulting from subjection to ischemia. In addition, NS-7 can be used as an agent for treating acute ischemic retinopathy, including diseases associated with very high intraocular pressure, such as acute angle-closure glaucoma.

Cited by 8 publications

References 38 publications

Effect of Flunarizine, a Calcium Channel Blocker, on Intraocular Pressure and Aqueous Humor Dynamics in Monkeys

Effect of Flunarizine, a Calcium Channel Blocker, on Intraocular Pressure and Aqueous Humor Dynamics in Monkeys

Influence of Trace Elements on Neurodegenerative Diseases of The Eye—The Glaucoma Model

The neuroprotective effect of submicron and blended <i>Lycium barbarum</i> for experiment retinal ischemia and reperfusion injury in rats

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