Neuroprotective effect of safranal, an active ingredient of  Crocus sativus , in a rat model of transient cerebral ischemia

Sadeghnia, Hamid Reza; Shaterzadeh, Hamideh; Forouzanfar, Fatemeh; Hosseinzadeh, Hossein

doi:10.5114/fn.2017.70485

Cited by 62 publications

(34 citation statements)

References 26 publications

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“…The serum antioxidant (reducing) power was measured using the FRAP assay. 26 Briefly, 50 μL of serum was added to 1.5 mL of freshly prepared and pre-warmed (37°C) FRAP reagent (300 mM acetate buffer, 10 mM TPTZ in 40 mM HCl, and 20 mM FeCl 3 in the ratio of 10:1:1) in a test tube and incubated at 37°C for 8 minutes. The optical density of the blue colored complex was read against the blank reagent at 593 nm.…”

Section: Assay Of Frapmentioning

confidence: 99%

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<p>Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats</p>

Khorrami

Sadeghnia

Pasdar

et al. 2019

IJN

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Purpose The purpose of this study was to investigate the acute toxic potential of cerium oxide nanoparticles (CNPs) synthesized by pullulan in adult male Wistar rats. Patients and methods Thirty male Wistar rats randomly were divided into five experimental groups of six animals each. The animals were received 50, 100, 200, and 400 mg/kg CNPs for 14 consecutive days. At the end of the experiment, the rats were euthanized and histopathological evaluation of the liver and renal tissues, as well ass, the markers of serum oxidative stress including thiobarbituric acid reactive substances, total sulfhydryl content, and antioxidant capacity (using ferric reducing/antioxidant power assay) were assessed. Hematological parameters and the activity of liver function enzymes were also measured. Results The results of this study showed that CNPs caused no significant changes in the activity of liver enzymes, hepatic and renal histopathology and hematological parameters, while significantly improved serum redox status. Conclusion Acute administration of pullulan-mediated CNPs is safe and possess antioxidant activity.

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Section: Assay Of Frapmentioning

confidence: 99%

“…25 assay of total sh groups Total SH groups were measured using 5,5′-dithiobis-2-nitrobenzoic acid (DTNB). 26 Briefly, 1 mL of Tris-EDTA buffer (pH 8.6) was added to 50 μL of serum and 50 μL of the sample. The sample absorbance was observed at 412 nm against Tris-EDTA buffer (A1).…”

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confidence: 99%

<p>Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats</p>

Khorrami

Sadeghnia

Pasdar

et al. 2019

IJN

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“…Natural products, principally herbal medicines, have long been considered as a rich source of therapeutic agents . In recent times, the belief that natural medicines having fewer side effects than synthetic drugs have become very popular and has led to a huge increase in phytopharmaceutical usage throughout the world.…”

Section: Herbal Medicine Strategymentioning

confidence: 99%

“…Natural products, principally herbal medicines, have long been considered as a rich source of therapeutic agents. 14,15 In recent times, the belief that natural medicines having fewer side effects than synthetic drugs have become very popular and has led to a huge increase in phytopharmaceutical usage throughout the world. In terms of herbal medicines, increasing demand for medicinal plants and related compounds has been spurred by their global use for the treatment of a myriad of diseases.…”

Section: Herbal Medicine Strategymentioning

confidence: 99%

Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

et al. 2019

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Cancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress‐inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti‐inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.

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“…Crocus sativus (Iridaceae), generally known as saffron, is cultivated in Iran and also in some other countries such as Spain, Italy, Greece and Azerbaijan [14]. Safranal, a monoterpene aldehyde, is the major component of C. sativus essential oil [15,16]. Several neuropharmacological activities of safranal have been reported in various researches including antioxidant [17], hypnotic and anxiolytic [18], antidepressant, analgesic, anti-inflammatory [19] and anticonvulsant [20].…”

Section: Resultsmentioning

confidence: 99%

Safranal Attenuates Excitotoxin-Induced Oxidative OLN-93 Cells Injury

et al. 2018

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Objectives Researches have been shown that glutamic acid (GA) or quinolinic acid (QA) can play role in neuroinflammatory and demyelinating diseases including multiple sclerosis (MS), mainly via oligodendrocytes activation and extreme free radicals generation. Recent studies have demonstrated that safranal, an active constituent of Crocus sativus, has several pharmacological effects such as antioxidant, anti-inflammatory and neuroprotective properties. Since there is no data about the impact of safranal on MS, this study was designed to investigate the protective effect of safranal on OLN-93 oligodendrocytes injury induced by GA or QA. Materials and Methods At first, the potential toxic effect of safranal on OLN-93 viability was evaluated. Also, the cells were pretreated with safranal (0.1, 1, 10, 50, 100 and 200 μM) for 2 h and then subjected to GA (16 mM) or QA (8 mM) toxicity for 24 h, in which the same treatments were applied. The cell viability and parameters of redox status such as the levels of intracellular reactive oxygen species (ROS) and lipid peroxidation were measured. Results Safranal at concentration ranges of 1–800 μM had no toxic effect on cell viability (p>0.05). Treatment with safranal significantly increased cell viability following GA or QA insults at concentrations higher than 1 μM (p<0.01). The cytoprotective potential of safranal was also accompanied by decreased ROS accumulation (p<0.001) and malondialdehyde level (p<0.001) following GA or QA insults. Conclusion The data suggests that safranal exhibits oligoprotection potential by means of inhibiting oxidative stress parameters.

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Neuroprotective effect of safranal, an active ingredient of Crocus sativus , in a rat model of transient cerebral ischemia

Abstract: A b s t r a c tSafranal is a monoterpene aldehyde found in saffron (Crocus sativus L.)

Cited by 62 publications

References 26 publications

<p>Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats</p>

<p>Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats</p>

Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

Safranal Attenuates Excitotoxin-Induced Oxidative OLN-93 Cells Injury

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