Neuroprotective Effect of Repeated Treatment with Hericium erinaceum in Mice Subjected to Middle Cerebral Artery Occlusion

Abstract

The neuroprotective effects of Hericium erinaceum (H. erinaceum) were studied in mice subjected to middle cerebral artery (MCA) occlusion. Infarct volumes were markedly reduced in mice receiving 14 days of H. erinaceum (300 mg/kg) treatment prior to 4-hr MCA occlusion. Moreover, 14-day pre-ischemic H. erinaceum treatment significantly increased the levels of nerve growth factor (NGF) in both the cortex and striatum of mice subjected to 4-hr MCA occlusion. However, pre-ischemic H. erinaceum treatment had no effect on cerebral blood flow (CBF) in the cortex of mice subjected to MCA occlusion. Treatment with H. erinaceum for 1 day prior to MCA occlusion-induced ischemia had no effect on infarct volume or NGF level. These results suggest that 14 days of treatment with H. erinaceum prior to MCA occlusion protected against focal cerebral ischemia, by increasing NGF levels. This implies that H. erinaceum and its components could be useful for preventing cerebral infarction.

Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber‐CA3 Hippocampal Neurotransmission and Recognition Memory in Wild‐Type Mice

“…Previous studies showed that H. erinaceus oral supplementation in mice with learning and memory deficits induced by intracerebroventricular administration of A β (25–35) amyloid β (25–35) peptide prevented cognitive deficits in a memory recognition task but not in a spatial working task [3]. Based on these findings, we decided to test the effect of H. erinaceus on recognition memory in wild-type mice by using the NOR task (Figure 2).…”

“…Recently, Hazekawa et al [3] described the neuroprotective effects of H. erinaceus dietary supplementation in mice subjected to middle cerebral artery occlusion. Furthermore, scores on the cognitive function scale improved after oral administration of H. erinaceus in patients suffering from mild cognitive impairment [4].…”

Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging

“…Existing data have suggested that there is a neuroprotective effect of dietary supplementation with H. erinaceus in mice subjected to middle cerebral artery occlusion [23]. Furthermore, H. erinaceus provided a partial recovery of intellectual function of patients with a mild cognitive impairment or against other forms of neurodegenerative diseases, including dementia and Alzheimer’s [24,25,26].…”

Нейропластичность И Постинсультные Когнитивные Нарушения (Терапевтические Возможности)

“…В экспериментальной модели инсульта показано, что введение эриноцина А в первые 90 минут после развития острого нарушения мозгового кровообращения приводило к ослаблению экспрессии провоспалительных цитокинов, снижению проявлений апоптоза и уменьшению объема инфаркта мозга [106]. Предварительный прием в течение 14 дней экстракта Hericium erinaceus до развития инсульта, смоделированного путем контролируемой окклюзии средней мозговой артерии, способствовал достоверному возрастанию синтеза NGF и регрессу неврологических симптомов [107].…”