Neuroprotective Effect of Ponicidin Alleviating the Diabetic Cognitive Impairment: Regulation of Gut Microbiota

Guo, Fanjia; Cao, Dujuan; Yan, Yinan; Zhang, Ning; Zhang, Kaili; Kumar, Prashant; Zhang, Xiaojuan

doi:10.1007/s12010-022-04113-1

Cited by 2 publications

(2 citation statements)

References 71 publications

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“…Hara, Lamiaceae), decreased the relative abundance of Firmicutes and increased the relative abundance of Bacteroidetes . Moreover, it restored the relative abundances of the Allobaculum , Lactobacillus , and Ruminococcus genera, which means that it has a neuroprotective effect against diabetic cognitive impairment through modulating the gut microbiome [ 146 ].…”

Section: Tcms Intervention In Patients With T2dm and Its Complication...mentioning

confidence: 99%

Modulating the Gut Microbiota and Metabolites with Traditional Chinese Medicines: An Emerging Therapy for Type 2 Diabetes Mellitus and Its Complications

Jiang,

Di,

Huang

et al. 2024

Molecules

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Currently, an estimated 537 million individuals are affected by type 2 diabetes mellitus (T2DM), the occurrence of which is invariably associated with complications. Glucose-lowering therapy remains the main treatment for alleviating T2DM. However, conventional antidiabetic agents are fraught with numerous adverse effects, notably elevations in blood pressure and lipid levels. Recently, the use of traditional Chinese medicines (TCMs) and their constituents has emerged as a preferred management strategy aimed at curtailing the progression of diabetes and its associated complications with fewer adverse effects. Increasing evidence indicates that gut microbiome disturbances are involved in the development of T2DM and its complications. This regulation depends on various metabolites produced by gut microbes and their interactions with host organs. TCMs’ interventions have demonstrated the ability to modulate the intestinal bacterial microbiota, thereby restoring host homeostasis and ameliorating metabolic disorders. This review delves into the alterations in the gut microbiota and metabolites in T2DM patients and how TCMs treatment regulates the gut microbiota, facilitating the management of T2DM and its complications. Additionally, we also discuss prospective avenues for research on natural products to advance diabetes therapy.

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Section: Tcms Intervention In Patients With T2dm and Its Complication...mentioning

confidence: 99%

Modulating the Gut Microbiota and Metabolites with Traditional Chinese Medicines: An Emerging Therapy for Type 2 Diabetes Mellitus and Its Complications

Jiang,

Di,

Huang

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

“…Ponicidin is a diterpenoid isolated from a Chinese traditional herb Rabdosia rubescens. As diabetes mellitus is an important factor contributing to cognitive impairment by increasing the production of free radicals and enhancing inflammatory reactions, there is evidence supporting the neuroprotective role of ponicidin in alleviating diabetic cognitive dysfunction a in rat model ( Zhang X. et al, 2023 ). This study showed that ponicidin significantly attenuated cognitive impairment not only through alleviating inflammation and oxidative stress, but also through modulating gut microbiota.…”

Section: Herbal Medicine and Admentioning

confidence: 99%

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Liu,

Li,

Liang

et al. 2024

Front. Pharmacol.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. It severely affects the quality of life of victims. The prevalence of AD has been increasing in recent years. Therefore, it is of great importance to elucidate the pathogenic mechanism of AD and search for effective therapeutic approaches. Gut microbiota dysbiosis, an altered state of gut microbiota, has been well known for its involvement in the pathogenesis of AD. Much effort has been made in searching for approaches capable of modulating the composition of gut microbiota in recent years. Herbal medicines have attracted extensive attention in recent decades for the prevention and treatment of AD. Here, we gave an overview of the recent research progress on the modulatory effects of herbal medicines and herbal formulae on gut microbiota as well as the possible beneficial effects on AD, which may provide new insights into the discovery of anti-AD agents and their therapeutic potential for AD through modulating the composition of gut microbiota.

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Neuroprotective Effect of Ponicidin Alleviating the Diabetic Cognitive Impairment: Regulation of Gut Microbiota

Cited by 2 publications

References 71 publications

Modulating the Gut Microbiota and Metabolites with Traditional Chinese Medicines: An Emerging Therapy for Type 2 Diabetes Mellitus and Its Complications

Modulating the Gut Microbiota and Metabolites with Traditional Chinese Medicines: An Emerging Therapy for Type 2 Diabetes Mellitus and Its Complications

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

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