Neuroprotective effect of phytoconstituents via nanotechnology for treatment of Alzheimer diseases

Paramanick, Debashish; Singh, Veena D.; Singh, Vijay Kumar

doi:10.1016/j.jconrel.2022.09.058

Cited by 19 publications

(15 citation statements)

References 171 publications

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“…[ 117 ] The lipophilic potency of NPs and the hydrophobic environment of enzymes AChE might be the possible mechanism for the binding affinity of nanoparticles to AChE. [ 118 ] The inactivation and inhibition of AChE by NPs might be because of conformational changes in the enzymes that occur as a result of enzyme interaction to the AgNPs' surface. [ 119,120 ]…”

Section: Discussionmentioning

confidence: 99%

Fabrication and characterization of Hypecoum pendulum‐assisted novel bio‐inspired silver nanoparticles and their antioxidant, anti‐diabetic, and anti‐Alzheimer properties

Huda

Ahmed

Mushtaq

et al. 2023

Applied Organom Chemis

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This research aims to study the biogenic synthesis and characterization of Hypecoum pendulum extract-induced silver nanoparticles (HP-AgNPs) and to investigate its antioxidant, anti-alpha-amylase, and anti-acetylcholinesterase (AChE) activities. UV spectrometry at 417 nm with an surface plasmon resonance (SPR) peak of 1.54 confirmed the biosynthesis of HP-AgNPs. X-ray diffraction (XRD) analysis demonstrated that HP-AgNPs are crystalline with a 36 nm size. The average size of 80 nm was confirmed by scanning electron microscopy (SEM) analysis. The functional moieties bearing compounds accountable for the encapsulation and stability of HP-AgNPs were assessed by the Fourier transform infrared (FTIR) technique. Energy dispersive X-ray (EDX) demonstrated that silver was the main element (49%) of HP-AgNPs. HP-AgNPs showed the promising antioxidant potential of ABTS (71.57%), diphenyl-1-picrylhydrazyl (DPPH, 69.46%), H 2 O 2 (66.94%), ferric chloride (73.71%), and ammonium molybdenum (65.7%). HP-AgNPs exhibited significant enzymatic inhibition potential with IC 50 of 48.8 ± 4.03 μg/mL (α-amylase) and 51.78 ± 3.16 μg/mL (AChE). Kinetics studies showed that HP-AgNPs produced mixed-type inhibition against α-amylase (K m increased from 40.65 to 131.44%, whereas V max decreased from 4.14 to 9.77%) and non-competitivetype inhibition (V max decreased from 17.05 to 62.03% and K m remain constant) against AChE. Finally, it may be concluded that HP-AgNPs may possess anti-Alzheimer, anti-diabetic, and antioxidant capabilities.

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Section: Discussionmentioning

confidence: 99%

Fabrication and characterization of Hypecoum pendulum‐assisted novel bio‐inspired silver nanoparticles and their antioxidant, anti‐diabetic, and anti‐Alzheimer properties

Huda

Ahmed

Mushtaq

et al. 2023

Applied Organom Chemis

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“…However, phyto components in their native form show poor bioavailability, low solubility and insufficient BBB permeability, which restrict their effective application. Nanotechnology in this regard has been accepted as an innovative technique to overcome these brain medication delivery restrictions [50]. Phyto constituents loaded NCs have the potential to overcome these challenges while also improving neuroprotective effects in BBB.…”

Section: Some Important Brain Disorders Their Etiology and Treatment ...mentioning

confidence: 99%

“…Phyto constituents loaded NCs have the potential to overcome these challenges while also improving neuroprotective effects in BBB. A numbers of pre-clinical studies on phyto component loaded NCs nanocarriers to treat AD have been reported [28,50]. However, development of NCs for delivery of phyto componets in AD is still limited due to challenging formulation procedures at industrial prospects [51].…”

Section: Some Important Brain Disorders Their Etiology and Treatment ...mentioning

confidence: 99%

Recent Advancements in Phyto Component Based Nanocarriers for Improved Treatment of Brain Disorders

Satapathy¹,

Pattnaik²,

Biswal³

et al. 2023

Drug Repurposing - Advances, Scopes and Opportunities in Drug Discovery

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Effective treatment of brain disorders remains a tough task in medical science. Age-old brain disorders like Parkinson’s (PD) and Alzheimer’s (AD) are yet to be managed effectively in spite of fabulous scientific progress over the last decades. Presently available treatment strategies have been found insufficient to tackle the out bursting cases of AD and PD. Indeed, presence of blood-brain barrier (BBB) highly hijacks success of conventional drug therapy. In this regard, phyto bioactive components delivered through nanocarrier (NCs) systems hold ray of hope in improving treatment benefits in brain disorders. Several NCs including polymeric nanoparticles, nanoliposomes, micelles, dendrimers have now being heavily researched to effectively deliver the phyto active components to brain tissue. NCs owing to their structural and physiological uniqueness have now been evolved with great potential for the treatment of brain disorders. Functionalization of brain specific ligands on the surface of NCs further makes them target specific, which might significantly improve bioavailability or reduce the off-target adverse effects. This chapter primarily focuses on recent advancements in phyto component loaded NCs employed for the treatment of brain disorders. The chapter especially covers existing impediments of phyto component based NCs for Parkinson and Alzheimer’s disease.

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“…In brain drug delivery, the nanoparticles play a crucial role and they are the most commonly used drug delivery system for the delivery of anticancer and other drugs for the treatment of neurodegeneration. Nanoparticles (NPs) have shown remarkable outcomes to target drugs for the treatment of neurodegenerative disease (Paramanick et al, 2022). NPs minimise the therapeutic dose, thereby reducing the adverse effect and also reported to have less frequency in administration.…”

Section: Nanoparticles For Treatment Of Neurodegenerationmentioning

confidence: 99%

“…Nanoformulations with active components of phytoconstituents were highly therapeutically active due to their direct target distribution. Many phytocomponents (curcumin, resveratrol and luteolin) in the form of nanoparticles were studied by researchers, and it revealed that the formulation exhibited optimised therapeutic effect and high drug concentration with minimal or negligible adverse drug effects (Paramanick et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Phytonanoparticles for the treatment of Alzheimer’s disease: A review

Chellammal¹,

Singh²,

Kumar³

et al. 2022

J. Phytonanotech. Pharmaceut. Sci.

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Alzheimer's disease, (AD) is a neurodegenerative disease characterized by cognitive dysfunction and is an age-related disease. The neuropathology of AD is -amyloid (A) peptide in the brain and causes neurofibrillary tangles. The acetylcholine level is reduced in the hippocampus and acetylcholinesterase (AChE) is enhanced causing memory deterioration. Oxidative damage is one of the major cellular impacts affected during AD condition. Plant derived polyphenols are the compounds which are having remarkable effect of free radical scavenging effect and AChE inhibitory effect in brain. The treatment with phytocompounds were highly effective for neuroprotection and systematically regulates the brain organic balance. The limitations of phytocompounds to penetrate the blood brain barrier is majorly surpassed by the novel drug delivery systems such as nanoparticles. Nanoformulations of phytocompounds have a greatest potential for the target delivery of drugs to the brain and have maximal therapeutic effect. This review states the remarkable impacts of selected phytonanoparticles for the treatment of AD.

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Neuroprotective effect of phytoconstituents via nanotechnology for treatment of Alzheimer diseases

Cited by 19 publications

References 171 publications

Fabrication and characterization of Hypecoum pendulum‐assisted novel bio‐inspired silver nanoparticles and their antioxidant, anti‐diabetic, and anti‐Alzheimer properties

Fabrication and characterization of Hypecoum pendulum‐assisted novel bio‐inspired silver nanoparticles and their antioxidant, anti‐diabetic, and anti‐Alzheimer properties

Recent Advancements in Phyto Component Based Nanocarriers for Improved Treatment of Brain Disorders

Phytonanoparticles for the treatment of Alzheimer’s disease: A review

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