Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat

Liu, Jiping; Feng, Liang; Ma, Dongying; Zhang, Minghua; Gu, Junfei; Wang, Shuyuan; Fu, Qiang; Song, Yu; Lan, Zhou; Qu, Rong

doi:10.1016/j.neulet.2013.06.002

Cited by 67 publications

(57 citation statements)

References 21 publications

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“…In our study, caspase-3, -9 and -8 expressions were observed to increase in diabetic rats. Consistent to our results, increased activitiy of these caspases, especially caspase-3, has been reported in the hippocampus and other neuronal tissues in both in vivo and in vitro models of diabetes (Piotrowski et al, 2001;Jafari Anarkooliet al, 2008;Sharifi et al, 2009;Bournival et al, 2012;Hao et al, 2012;Huang et al, 2012;Liu et al, 2013). In the present study, GSE proanthocyanidins significantly decreased caspase-3, -9 and -8 expressions in the hippocampus of diabetic rats.…”

Section: Accepted Manuscriptsupporting

confidence: 92%

“…Additionally, induction of the apoptosis by increased activation of pro-inflammatory cytokines such as Nuclear Factor KappaB (NF-kB) (Alvarez-Nölting et al, 2012;Muriach et al, 2006;Jing et al, 2013) and Tumor Necrosis Factor-α (TNF-α) (Marfella et al, 2006;Jing et al, 2013) in streptozotocin (STZ) diabetic rats have been previously reported. Consistent to the above mentioned mechanisms, increased numbers of TUNEL positive cells have been observed in various brain regions of diabetic animals (Li et al, 2002;Hernández-Fonseca et al 2009;Huang et al 2012;Liu et al, 2013).…”

Section: Introductionsupporting

confidence: 72%

“…In recent studies, the number of TUNEL positive cells have been observed to increase more in the brains of diabetic animals than in those of the controls (Huang et al, 2012;Liu et al, 2013); but this increase failed to reach statistical significance in the study by Hernández-Fonseca et al (2009). We found in our study that there was significantly more neuronal apoptosis in the hippocampus of diabetic rats than in those of the controls.…”

Section: Accepted Manuscriptcontrasting

confidence: 66%

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Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

Yonguc

Dodurga

Adıgüzel

et al. 2015

Gene

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Section: Accepted Manuscriptsupporting

confidence: 92%

Section: Introductionsupporting

confidence: 72%

Section: Accepted Manuscriptcontrasting

confidence: 66%

See 1 more Smart Citation

Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

Yonguc

Dodurga

Adıgüzel

et al. 2015

Gene

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“…Administration of BDNF in the brain was found to remarkably reduce food intake, increase energy expenditure and alleviate hyperinsulinaemia and hyperglycemia in diabetic db/db mice [10]. More importantly, a previous investigation illustrated that decreased levels of BDNF in hippocampus contributed to the impaired cognitive performance in streptozotocin (STZ)-induced diabetic rats [11]. Taking into account the fact that BDNF is closely linked with cognition, it is of great interest to explore the neuroprotective agents that may attenuate the cognitive decline due to diabetes.…”

Section: Introductionmentioning

confidence: 99%

Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats

Mao

Cao

et al. 2014

IJMS

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The present study was designed to probe the effects of Huperzine A (HupA) on diabetes-associated cognitive decline (DACD) using a streptozotocin (STZ)-injected rat model. Diabetic rats were treated with HupA (0.05 and 0.1 mg/kg) for seven weeks. Memory functions were evaluated by the water maze test. Nissl staining was selected for detecting neuronal loss. Protein and mRNA levels of brain-derived neurotrophic factor (BDNF) were analyzed by ELISA and real-time PCR, respectively. The activities of choline acetylase (ChAT), Acetylcholinesterase (AChE), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), NF-κB p65 unit, TNF-α, IL-1β, IL-6 and caspase-3 were measured using corresponding kits. After seven weeks, diabetic rats exhibited remarkable reductions in: body weight, percentage of time spent in target quadrant, number of times crossing the platform, ChAT and BDNF levels, SOD, GSH-Px and CAT accompanied with increases in neuronal damage, plasma glucose levels, escape latency, mean path length, AChE, MDA level as well as CAT, NF-κB p65 unit, TNF-α, IL-1β, IL-6 and caspase-3 in cerebral cortex and hippocampus. Supplementation with HupA significantly and dose-dependently reversed the corresponding values in diabetes. It is concluded that HupA ameliorates DACD via modulating BDNF, oxidative stress, inflammation and apoptosis.

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“…As compared with other chemical agent such as alloxan, streptozotocin has more specificity to langerhans' b cell, less toxicity, and higher successful rate. This model is similar to diabetic patients in clinical (28)(29)(30)(31)(32). So hyperlipidemia combined with streptozotocin diabetic model was used in current study.…”

Section: Figmentioning

confidence: 76%

Diversity of Vascular Reactivity and the Treatment Response in Diabetic, Hypertensive, Hyperlipidemic, and Healthy Rats Subjected to Hemorrhagic Shock

Zhu²,

Chen³

et al. 2016

Shock

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The current diagnosis and treatment guidelines for severe trauma and shock are all for healthy population. Few studies focused on the pathophysiological features and treatments in metabolic diseases after severe trauma and shock. Vascular reactivity is significantly decreased after severe trauma and shock. Improving the vascular reactivity with arginine vasopressin (AVP) and phorbol-12 myristate-13-acetate (PMA) is beneficial to trauma and shock. Whether the cardiovascular function and treatment responses have the own features in hypertensive, diabetic, and hyperlipidemic patients after traumatic hemorrhagic shock is not known. Using hypertensive, diabetic, and hyperlipidemic and healthy rats, we compared the change patterns in cardiovascular function including vascular reactivity, tissue perfusion, and the hemodynamics after hemorrhagic shock and their responses to AVP, PMA, and common antishock agents including dopamine and norepinephrine. A same degree of hemorrhagic shock (40% hemorrhage or mean arterial pressure maintained at 40 mm Hg for 2 h) resulted in a more obvious decrease in vascular reactivity, hemodynamics, tissue perfusion, and mitochondrial function of liver and kidney in hypertensive, diabetic, and hyperlipidemic rats, and a more rapidly natural death than in healthy rats. The effectiveness of AVP and PMA in these diseased rats was lower than in healthy rats. The effective dosage of common antishock agents including norepinephrine, dopamine, and AVP in healthy rats was wider than that in these diseased rats. Among the antishock agents used in the current study, AVP had the best effect in improving animal survival and vascular reactivity both in healthy and in diseased rats. These findings suggest that hypertensive, diabetic, and hyperlipidemic rats have a worse vascular reactivity and organ function than the healthy rats after traumatic hemorrhagic shock, which result in the worse treatment responses and effects to vasoactive agents. Lower dose of AVP can be recommended as the first-line antishock agents for these diseased rats.

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Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat

Cited by 67 publications

References 21 publications

Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

Grape seed extract has superior beneficial effects than vitamin E on oxidative stress and apoptosis in the hippocampus of streptozotocin induced diabetic rats

Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats

Diversity of Vascular Reactivity and the Treatment Response in Diabetic, Hypertensive, Hyperlipidemic, and Healthy Rats Subjected to Hemorrhagic Shock

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