Neuroprotective Effect of Nosustrophine in a 3xTg Mouse Model of Alzheimer’s Disease

Abstract

Neurodegeneration, characterized by the progressive deterioration of neurons and glial cells, is a feature of Alzheimer’s disease (AD). The present study aims to demonstrate that the onset and early progression of neurodegenerative processes in transgenic mice models of AD can be delayed by a cocktail of neurotrophic factors and derived peptides named Nosustrophine, a nootropic supplement made by a peptide complex extracted from the young porcine brain, ensuring neuroprotection and improving neuro-functional recovery. Experimental 3xTg-APP/Bin1/COPS5 transgenic mice models of AD were treated with Nosustrophine at two different early ages, and their neuropathological hallmark and behavior response were analyzed. Results showed that Nosustrophine increased the activity of the immune system and reduced pathological changes in the hippocampus and cortex by halting the development of amyloid plaques, mainly seen in mice of 3–4 months of age, indicating that its effect is more preventive than therapeutic. Taken together, the results indicate the potent neuroprotective activity of Nosustrophine and its stimulating effects on neuronal plasticity. This study shows for the first time an effective therapy using nootropic supplements against degenerative diseases, although further investigation is needed to understand their molecular pathways.

Neuronal Protective Effect of Nosustrophine in Cell Culture Models

“…At present, there are no effective therapeutics available for neurodegenerative disorders. 10 It similarly shows how various studies address the usefulness of Nosustrophine, particularly Carrera et al 11 highlight its usefulness as an effective therapy using nootropic supplements against degenerative diseases, while several authors delve into deeper cellular and molecular mechanisms, reflexively highlighting its validity as exerts substantial epigenetic effects against AD-related neurodegeneration. 12, 13 Particularly in their work, Carrera et al 14 effectively illustrate the neuronal protective effect of Nosustrophine in cell culture models by highlighting how this is an epigenetic bioproduct derived from the brain of Sus scrofa domesticus using nondenaturing biotechnological processes on the progression of neurodegeneration in human neuroblastoma cell line SH-SY5Y.…”