Neuroprotective effect of Korea Red Ginseng extract on 1-methyl-4-phenylpyridinium-induced apoptosis in PC12 Cells

Ryu, Sun Young; Koo, Sungtae; Ha, Ki‐Tae; Kim, Seungtae

doi:10.1080/19768354.2016.1257510

Cited by 12 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A separate study done by the same group reported that Korean red ginseng also alleviated the protein expression profile in the substantia nigra that involved in the neuronal development and energy metabolism for the neuronal survival as well as neuroprotection [148]. Meanwhile, in the cellular model, Korean red ginseng treatment inhibited 1-methyl-4-phenylpyridinium ion-(MPP + -) induced apoptosis on rat pheochromocytoma (PC12) cells by preventing the decrease of cell viability and apoptosis and decreasing mRNA expressions of caspase-3 and caspase-9 [149]. Furthermore, this group also reported that Korean red ginseng treatment alleviated behavioral dysfunction induced by MPTP and enhanced differentiation and proliferation of endogenous neural stem cells in the subventricular zone of MPTP-induced mice [150].…”

Section: Ginseng Ginseng Is a Perennial Herb Belonging To Thementioning

confidence: 99%

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Sairazi

Sirajudeen

2020

Evidence-Based Complementary and Alternative Medicine

128

View full text Add to dashboard Cite

In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.

show abstract

Section: Ginseng Ginseng Is a Perennial Herb Belonging To Thementioning

confidence: 99%

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Sairazi

Sirajudeen

2020

Evidence-Based Complementary and Alternative Medicine

128

View full text Add to dashboard Cite

show abstract

“…In Parkinson’s animal model (pole test), Korean red ginseng, a perennial herb, could enhance the behavioral impairment of mice and prevent dopaminergic neuronal demise and apoptosis in an MPTP-induced model [ 150 ]. In a cellular model, treatment with Korean red ginseng inhibited apoptosis induced by 1-methyl-4-phenylpyridinium ion- (MPP+) on PC12 cells of rat by impeding the cell viability decline and apoptosis via decrease of mRNA expressions of caspase-3 and -9 [ 151 ]. Shim et al showed that Uncaria rhynchophylla reduced ROS production and neuronal cell demise as well as prevented the caspase-3 activity in 6-OHDA-induced toxicity (PC12 cells) [ 152 ].…”

Section: Nutraceuticals In Nds: Multi-targeted Avenuementioning

confidence: 99%

Elucidating the Multi-Targeted Role of Nutraceuticals: A Complementary Therapy to Starve Neurodegenerative Diseases

Behl

Kaur

Sehgal

et al. 2021

IJMS

View full text Add to dashboard Cite

The mechanisms underlying multifactorial diseases are always complex and challenging. Neurodegenerative disorders (NDs) are common around the globe, posing a critical healthcare issue and financial burden to the country. However, integrative evidence implies some common shared mechanisms and pathways in NDs, which include mitochondrial dysfunction, neuroinflammation, oxidative stress, intracellular calcium overload, protein aggregates, oxidative stress (OS), and neuronal destruction in specific regions of the brain, owing to multifaceted pathologies. The co-existence of these multiple pathways often limits the advantages of available therapies. The nutraceutical-based approach has opened the doors to target these common multifaceted pathways in a slow and more physiological manner to starve the NDs. Peer-reviewed articles were searched via MEDLINE and PubMed published to date for in-depth research and database collection. Considered to be complementary therapy with current clinical management and common drug therapy, the intake of nutraceuticals is considered safe to target multiple mechanisms of action in NDs. The current review summarizes the popular nutraceuticals showing different effects (anti-inflammatory, antioxidant, neuro-protectant, mitochondrial homeostasis, neurogenesis promotion, and autophagy regulation) on vital molecular mechanisms involved in NDs, which can be considered as complementary therapy to first-line treatment. Moreover, owing to its natural source, lower toxicity, therapeutic interventions, biocompatibility, potential nutritional effects, and presence of various anti-oxidative and neuroprotective constituents, the nutraceuticals serve as an attractive option to tackle NDs.

show abstract

“…Korean Red Ginseng (KRG) is steamed and dried for lengthy preservation, which results in conversion of some of the chemical profiles of ginsenosides [6] . Previous studies have shown that ginseng and KRG suppressed 1-methyl-4-phenylpyridinium-induced cell death in PC12 [7] , [8] and SH-SY5Y [9] cells, and that oral administration of KRG extract protected dopaminergic cell death in the nigrostriatal pathway from MPTP toxicity [10] , [11] and improved cognitive functions in patients with Alzheimer's disease [12] . Moreover, ginsenoside Rg1 attenuated MPTP-induced behavioral impairment and dopaminergic neuronal death through the Wnt/β-catenin signaling pathway [13] and by reducing neuroinflammation [14] , whereas the ginsenoside Rd prevented 1-methyl-4-phenylpyridium-induced cell death in SH-SY5Y cells [15] , and ginsenoside Rb1 suppressed α-synuclein aggregation and toxicity [16] , indicating that KRG has the potential to alleviate PD symptoms; however, the mechanism is not fully understood.…”

Section: Introductionmentioning

confidence: 96%

Proteomic change by Korean Red Ginseng in the substantia nigra of a Parkinson's disease mouse model

Kim¹,

Kwon²,

Jeon³

et al. 2018

Journal of Ginseng Research

Self Cite

View full text Add to dashboard Cite

BackgroundRecent studies have shown that Korean Red Ginseng (KRG) successfully protects against dopaminergic neuronal death in the nigrostriatal pathway of a Parkinson's disease (PD) mouse model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration; however, the mechanism has yet to be identified. Therefore, in this study we used two-dimensional electrophoresis to investigate the effects of KRG on the changes in protein expression in the substantia nigra (SN) of MPTP-treated mice.MethodsMale C57BL/6 mice (9 wk old) were intraperitoneally administered MPTP (20 mg/kg) four times at 2-h intervals, after which KRG (100 mg/kg) was orally administered once a day for 5 d. Two hours after the fifth KRG administration, a pole test was conducted to evaluate motor function, after which the brains were immediately collected. Survival of dopaminergic neurons was measured by immunohistochemistry, and protein expression was measured by two-dimensional electrophoresis and Western blotting.ResultsKRG alleviated MPTP-induced behavioral dysfunction and neuronal toxicity in the SN. Additionally, the expression of eight proteins related to neuronal formation and energy metabolism for survival were shown to have changed significantly in response to MPTP treatment or KRG administration. KRG alleviated the downregulated protein expression following MPTP administration, indicating that it may enhance neuronal development and survival in the SN of MPTP-treated mice.ConclusionThese findings indicate that KRG may have therapeutic potential for the treatment of patients with PD.

show abstract

Neuroprotective effect of Korea Red Ginseng extract on 1-methyl-4-phenylpyridinium-induced apoptosis in PC12 Cells

Cited by 12 publications

References 13 publications

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Elucidating the Multi-Targeted Role of Nutraceuticals: A Complementary Therapy to Starve Neurodegenerative Diseases

Proteomic change by Korean Red Ginseng in the substantia nigra of a Parkinson's disease mouse model

Contact Info

Product

Resources

About