Neuroprotective effect of human placental extract on hypoxic–ischemic brain injury in neonatal rats

Park, Jee Yoon; Byeon, Jung Hye; Park, Sung Won; Chae, Kyu Young; Eun, Baik Lin

doi:10.1016/j.braindev.2012.01.009

Cited by 17 publications

(18 citation statements)

References 31 publications

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“…Therefore, the components in placental extracts can be very complex and may differ widely among products. Previous studies have indicated that placental extracts consist of N-acetylneuraminic acid, glucosamine, omega-3 fatty acids, diverse fatty acids, and many other amino acids and nucleotides [1, 2] that exhibit anti-oxidative or anti-inflammatory properties [3, 4, 7, 10, 38]. We speculated that our product of porcine placental extract might also contain most of these components.…”

Section: Discussionmentioning

confidence: 99%

Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity

Kawakatsu

Urata

Goto

et al. 2012

Journal of Radiation Research

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Placental extracts have been reported to have anti-oxidative and anti-inflammatory activities. Because there is increasing evidence that ionizing radiation induces the release of reactive oxygen species (ROS) and inflammatory cytokines, we examined the protective effects of a placental extract against radiation injury. C57BL/6 mice were exposed to 1 Gy of γ-ray radiation every day for 5 days, and placental extract (1 mg/day) was administrated orally soon after each exposure. At 2 days after the last irradiation, mice were euthanized to examine the numbers, colony-forming capacity, and DNA damage of stem/progenitor cells in the peripheral blood and bone marrow. To understand the related mechanisms, we also measured the levels of intracellular and mitochondrial ROS, and 8-OHdG in the plasma and urine, and IL-6 and TNF-α in the plasma. Compared with the placebo treatment, oral administration of placental extract significantly increased the number and colony-forming capacity, but decreased the DNA damage of bone marrow stem/progenitor cells. However, neither the levels of intracellular and mitochondrial ROS in bone marrow cells, nor the levels of 8-OHdG in the urine and plasma significantly differed between groups. Interestingly, in comparison with the placebo treatment, placental extract significantly decreased the levels of the inflammatory cytokines IL-6 and TNF-α in the plasma. Placental extract significantly attenuated the acute radiation injury to bone marrow-derived stem/progenitor cells, and this protection is likely to be related to the anti-inflammatory activity of the placental extract.

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Section: Discussionmentioning

confidence: 99%

Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity

Kawakatsu

Urata

Goto

et al. 2012

Journal of Radiation Research

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“…Podczas wizyty prezydenta Putina w Indiach, 4 grudnia 2002 r., została podpisana deklaracja delhijska na temat dalszej konsolidacji strategicznego partnerstwa pomiędzy obu krajami 25 . W następnym roku, 12 listopada, podczas wizyty premiera Vajpayee w Moskwie podpisano Deklarację na temat globalnych wyzwań i zagrożeń dla międzynarodowego bezpieczeństwa i stabilizacji.…”

Section: Aspekty Polityczneunclassified

“…W 2018 r. wśród pięciu największych partnerów handlowych Rosji znalazły się w kolejności: Chiny (108,3 mld USD), Niemcy (59,6 mld USD), Holandia (47,2 mld USD), Białoruś (34 mld USD) i Włochy (27 mld USD). Natomiast wśród największych partnerów handlowych Indii w roku fiskalnym 2017-2018 znalazły się: Chiny (89,7 mld USD), USA (74,5 mld USD), UAE -Zjednoczone Emiraty Arabskie (49,9 mld USD), Arabia Saudyjska (27,5 mld USD) i Hong Kong (25,4 mld USD) 61 . Natomiast za 2018 r., jak wynika z danych w tabeli 3, wartość obrotów rosyjsko-indyjskich wyniosła jedynie 9 mld 100 mln USD, co wyglądało bardzo blado w porównaniu do wartości obrotów handlowych Rosji z jej największymi partnerami handlowymi.…”

Section: Aspekty Gospodarczeunclassified

Współczesna Azja: aspekty polityczne, społeczne i kulturowe

Marszałek-Kawa¹,

Zajączkowski²

2021

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Wszystkie prawa zastrzeżone. Książka, którą nabyłeś, jest dziełem twórcy i wydawcy. Żadna jej część nie może być reprodukowana jakimkolwiek sposobem -mechanicznie, elektronicznie, drogą fotokopii itp. -bez pisemnego zezwolenia wydawcy. Jeśli cytujesz fragmenty tej książki, nie zmieniaj ich treści i koniecznie zaznacz, czyje to dzieło Toruń 2020 ISBN 978-83-8180-512-4 VII Międzynarodowy Kongres Azjatycki "Budowanie przyszłości państw: Tradycja, Teraźniejszość, Przyszłość" -zadanie dofinansowane w ramach umowy nr DNK/SP/4662466/2020 ze środków Ministra Edukacji i Nauki przeznaczonych na działalność upowszechniającą naukę Wydawnictwo prowadzi sprzedaż wysyłkową: tel.

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“…These findings support a protective effect of the HPE treatment on neuronal integrity and cognitive function following hypoxic-ischemic brain injury. Injected at an appropriate doseprior to exposure, HPE may significantly reduce or prevent hypoxic-ischemic injury in the immature brain [28] .…”

Section: Metastin and Stem Cells From Human Placentamentioning

confidence: 99%

Putative Prophylaxes Updated of Placenta Extract and Aloe vera as Biogenic Stimulants

Yagi

Ataka

2014

Journal of Gastroenterology and Hepatology Research

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Gastroenterology and Hepatology Researchdation, and the possible putative prophylaxes to optimize cognitive decline in older adults with pre-diabetes symptom. Because of the diversities of placental extract and Aloe vera as biogenic stimulants, present review introduced the briefly selected authors' intentions in each topical subject. Specially, the influence of gut microbiota to host is astonishing and highlighting that the consequence of our behaviours affect not only the environment without, but also that within us. Based on geriatric and neurological viewpoint, present review highlights current therapeutic strategies of placenta extract and Aloe vera as the so-called "biogenic stimulants", aimed at producing a biological rejuvenator in placental extract and improving cognitive function via modifying the brain's insulin sensitivity in Aloe vera.

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Neuroprotective effect of human placental extract on hypoxic–ischemic brain injury in neonatal rats

Cited by 17 publications

References 31 publications

Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity

Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity

Współczesna Azja: aspekty polityczne, społeczne i kulturowe

Putative Prophylaxes Updated of Placenta Extract and Aloe vera as Biogenic Stimulants

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