Neuroprotective effect of Decalepis hamiltonii aqueous root extract and purified 2-hydroxy-4-methoxy benzaldehyde on 6-OHDA induced neurotoxicity in Caenorhabditis elegans

Kamireddy, Kiran; Salim, Chinnu; Priyanka, P.; Rajini, P.S.; Giridhar, P.

doi:10.1016/j.biopha.2018.06.002

Cited by 27 publications

(7 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When administered to control strains of C. elegans 2—hydroxy–4—methoxybenzaldehyde per se did not induce any locomotion phenotypes. However, if administered to worms exposed to 6—hydroxydopamine (6—OHDA), a validated model of PD—like features that display slow and progressive degeneration of the dopamine system, this LMWPM can rescue some of the PD phenotypes [ 99 ]. After 6—OHDA administration, worms display a decrease in body bends compared to controls, a phenotype associated with 6—OHDA–induced PD.…”

Section: Low Molecular Weight (Poly)phenol Metabolites In Invertebrate Models Of Nddsmentioning

confidence: 99%

“…After 6—OHDA administration, worms display a decrease in body bends compared to controls, a phenotype associated with 6—OHDA–induced PD. Furthermore, in the same study, in the transgenic strain BZ555, in which dopaminergic neurons are tagged with GFP, co—exposed to 6—OHDA and 2—hydroxy–4—methoxybenzaldehyde, it was observed that the treatment conferred neurological protection, measured as the decrease of dopaminergic cell death and rescue of the locomotion phenotype [ 99 ].…”

Section: Low Molecular Weight (Poly)phenol Metabolites In Invertebrate Models Of Nddsmentioning

confidence: 99%

See 1 more Smart Citation

Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms

et al. 2021

View full text Add to dashboard Cite

The rise of neurodegenerative diseases in an aging population is an increasing problem of health, social and economic consequences. Epidemiological and intervention studies have demonstrated that diets rich in (poly)phenols can have potent health benefits on cognitive decline and neurodegenerative diseases. Meanwhile, the role of gut microbiota is ever more evident in modulating the catabolism of (poly)phenols to dozens of low molecular weight (poly)phenol metabolites that have been identified in plasma and urine. These metabolites can reach circulation in higher concentrations than parent (poly)phenols and persist for longer periods of time. However, studies addressing their potential brain effects are still lacking. In this review, we will discuss different model organisms that have been used to study how low molecular weight (poly)phenol metabolites affect neuronal related mechanisms gathering critical insight on their potential to tackle the major hallmarks of neurodegeneration.

show abstract

Section: Low Molecular Weight (Poly)phenol Metabolites In Invertebrate Models Of Nddsmentioning

confidence: 99%

Section: Low Molecular Weight (Poly)phenol Metabolites In Invertebrate Models Of Nddsmentioning

confidence: 99%

Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Decalepis hamiltonii is one such popularly known as swallow root and is endemic to the eastern and western Ghats of India (The Wealth of India, 1990). The plant is known for its rich natural flavour and bioactive properties, making it an important ingredient in various indigenous foods (Kamireddy et al ., 2018; Pradeep et al ., 2019). The major bioactive molecule of tuber constitutes 2‐hydroxy 4‐methoxybenzaldehyde, an isomer of vanillin (Nagarajan et al ., 2001), and successive attempts have been made by researchers to improve the flavour content of the D. hamiltonii tubers in vitro (Pradeep et al ., 2017; Koppada et al ., 2022) and ex vitro (Giridhar et al ., 2005; Pradeep et al ., 2019).…”

Section: Introductionmentioning

confidence: 99%

Physical characteristics, acceptability and biochemical properties of biscuits using Decalepis hamiltonii tuber extract as a natural flavouring agent

Sudha

Umashankar

Kumar

et al. 2023

Int J of Food Sci Tech

View full text Add to dashboard Cite

SummaryDecalepis hamiltonii natural flavour extract, an endemic flavour was first time used in food processing in biscuit formulation. 2‐hydroxy 4‐methoxybenzaldehyde (2H4MB), a structural isomer of vanillin is the major flavour‐attributing compound used. During the study, aqueous (6%–12%), and ethanolic (0.5%–2%) extracts, which are reported to be rich in flavour metabolites, and having antioxidan activity were used. These extracts were added at different concentrations and the physical, sensory, and biochemical properties of biscuits were evaluated along with bioactive retention. The breaking force required to break the +ve Control biscuit was 873 g force and was in the range between 916 and 988 g force for the biscuits with either of the tuber extracts. The biscuits made of ethanol extract have shown lighter colour with a low L value (61.84–58.36) compared to aqueous extract (63.67–56.87). Biscuit samples made with both aqueous and ethanol extracts showed good retention of bioactive compounds. However, the biscuit formulation with 1% ethanol extract showed good sensory (mouthfeel (8.7), flavour (8.6), and taste (8.6)) and in vitroantioxidant potential (11.6 ± 0.1 mg−1 100 g AAE) among formulations. The flavour metabolite in biscuits made of both extracts was quantified using HPLC and determined in range between 1 and 3 μg/g and compound presence is confirmed with mass spectrosocpy. With the present observations, we can infer that D. hamiltonii natural flavour extract can be used as an alternative to synthetic flavour in biscuit formulation.

show abstract

“…Oxidative Medicine and Cellular Longevity model to learn neurotoxicity and behavior in vivo [41]. Locomotor behaviors require the control of neural circuits [42].…”

mentioning

confidence: 99%

Tetrastigma hemsleyanum Vine Flavone Ameliorates Glutamic Acid-Induced Neurotoxicity via MAPK Pathways

Chu

Zheng

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Glutamic acid (Glu) is a worldwide flavor enhancer with various positive effects. However, Glu-induced neurotoxicity has been reported less. Tetrastigma hemsleyanum (TH), a rare herbal plant in China, possesses high medicinal value. More studies paid attention to tuber of TH whereas vine part (THV) attracts fewer focus. In this study, we extracted and purified flavones from THV (THVF), and UPLC-TOF/MS showed THVF was consisted of 3-caffeoylquinic acid, 5-caffeoylquinic acid, quercetin-3-O-rutinoside, and kaempferol-3-O-rutinoside. In vitro, Glu caused severe cytotoxicity, genotoxicity, mitochondrial dysfunction, and oxidative damage to rat phaeochromocytoma (PC12) cells. Conversely, THVF attenuated Glu-induced toxicity via MAPK pathways. In vivo, the neurotoxicity triggered by Glu restrained the athletic ability in Caenorhabditis elegans (C. elegans). The treatment of THVF reversed the situation induced by Glu. In a word, Glu could cause neurotoxicity and THVF owns potential neuroprotective effects both in vitro and in vivo via MAPK pathways.

show abstract

Neuroprotective effect of Decalepis hamiltonii aqueous root extract and purified 2-hydroxy-4-methoxy benzaldehyde on 6-OHDA induced neurotoxicity in Caenorhabditis elegans

Cited by 27 publications

References 66 publications

Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms

Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms

Physical characteristics, acceptability and biochemical properties of biscuits using Decalepis hamiltonii tuber extract as a natural flavouring agent

Tetrastigma hemsleyanum Vine Flavone Ameliorates Glutamic Acid-Induced Neurotoxicity via MAPK Pathways

Contact Info

Product

Resources

About