Neuroprotective Effect of Daidzein Extracted From Pueraria lobate Radix in a Stroke Model Via the Akt/mTOR/BDNF Channel

Zheng, Min; Zhou, Mi; Chen, Ming‐Hui; Lü, Yao; Shi, Dongxia; Wang, Jing; Liu, Chunming

doi:10.3389/fphar.2021.772485

Cited by 10 publications

(6 citation statements)

References 52 publications

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“…It is noteworthy, there is ample evidence demonstrating the neuroprotective effects of all the flavonoids studied in this research (Balaha et al, 2021; Bastianetto et al, 2006; Budzynska et al, 2019; Chen et al, 2017; Dourado et al, 2020; Hamdi et al, 2021; Hussein et al, 2018; Jamali‐Raeufy et al, 2019; Kempuraj et al, 2021; Khan et al, 2019; Kim et al, 2012; Liu et al, 2015; Nabavi et al, 2015, 2016; Nouri et al, 2019; Tao et al, 2018; Zheng et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the AChE dual-site inhibitors have attracted a lot of attention for more efficient treatment of AD (Zueva et al, 2019). It is noteworthy, there is ample evidence demonstrating the neuroprotective effects of all the flavonoids studied in this research (Balaha et al, 2021;Bastianetto et al, 2006;Budzynska et al, 2019;Chen et al, 2017;Dourado et al, 2020;Hamdi et al, 2021;Hussein et al, 2018;Jamali-Raeufy et al, 2019;Kempuraj et al, 2021;Khan et al, 2019;Kim et al, 2012;Liu et al, 2015;Nabavi et al, 2015Nabavi et al, , 2016Nouri et al, 2019;Tao et al, 2018;Zheng et al, 2021). TA B L E 9 The amino acid residues contributing in the interaction of propolis flavonoid compounds with BuChE determined using LigPlot software.…”

Section: Molecular Dockingmentioning

confidence: 99%

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Correlation between total phenolic and flavonoid contents and biological activities of 12 ethanolic extracts of Iranian propolis

Fathi Hafshejani

Lotfi

Rezvannejad

et al. 2023

Food Science & Nutrition

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Propolis is a resinous substance produced by honey bees that is very popular as a natural remedy in traditional medicine. The current research is the first study on the biological properties of ethanolic extracts of propolis (EEP) from several different regions (12) of Iran. Total phenolic and flavonoid contents (TPC and TFC) of Iranian EEPs were variable between 26.59-221.38 mg GAE/g EEP and 4.8-100.03 mg QE/g EEP. The DPPH scavenging assay showed all the studied EEP samples, except for the sample with the lowest TPC and TFC (P6), have suitable antioxidant activity. All the EEPs inhibited both cholinesterase enzymes (acetylcholinesterase: AChE, butyrylcholinesterase: BuChE) but most of them exhibited a distinct selectivity over BuChE.Evaluation of the antibacterial activity of the EEP samples using four pathogenic bacteria (B. cereus, S. aureus, A. baumannii, and P. aeruginosa) demonstrated that the antibacterial properties of propolis are more effective on the gram-positive bacterium.Spearman correlation analysis showed a strong positive correlation between TPC and TFC of the Iranian EEPs and their antioxidant, anticholinesterase, and antibacterial activities. Considering that there is ample evidence of anticholinesterase activity of flavonoids and a significant correlation between the anticholinesterase activity of the studied Iranian EEPs and their total flavonoid content was observed, the interaction of 17 well-known propolis flavonoids with AChE and BuChE was explored using molecular docking. The results indicated that all the flavonoids interact with the active site gorge of both enzymes with high affinity. Summing up, the obtained results suggest that Iranian propolis possesses great potential for further studies.

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Section: Resultsmentioning

confidence: 99%

Section: Molecular Dockingmentioning

confidence: 99%

Correlation between total phenolic and flavonoid contents and biological activities of 12 ethanolic extracts of Iranian propolis

Fathi Hafshejani

Lotfi

Rezvannejad

et al. 2023

Food Science & Nutrition

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“…Moreover, DZ treatment at a concentration of 30 mg/kg enhanced the expression of BDNF and CREB. These outcomes demonstrated that DZ could protect animals against ischemic damage through the regulation of the Akt/mTOR/BDNF channel (Zheng et al, 2022).…”

Section: Molecular Targets Of Phytoestrogen‐isoflavones In Neurodegen...mentioning

confidence: 98%

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

Al‐Shami

Essawy

Elkader

2023

Phytotherapy Research

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Neurodegenerative disorders are heterogeneous, debilitating, and incurable groups of brain disorders that have common features including progressive degeneration of the structure and function of the nervous system. Phytoestogenic‐isoflavones have been identified as active compounds that can modulate different molecular signaling pathways related to the nervous system. The main aim is to shed the light on the molecular mechanisms followed by phytoestrogen‐isoflavones profound in the Trifolium pratense and discuss the latest pharmacological findings in the treatment of neurodegenerative disorders. Data were collected using different databases. The search terms used included “Phytoestrogens,” “Isoflavones,” “neurodegenerative disorders,” “Neuronal plasticity,” etc., and combinations of these keywords. As a result, this review article mainly demonstrates the potential neuroprotective properties of phystoestrogen‐isoflavones present in the Trifolium pratense (Red clover), particularly in neurodegenerative disorders. Phytochemical studies have shown that Trifolium pratense mainly includes more than 30 isoflavone compounds. Among them, phytoestrogen‐isoflavones, such as biochanin A, daidzein, formononetin, genistein (Gen), etc.,are characterized by potent neuroprotective properties against different neurodegenerative disorders. There are preclinical and clinical scientific evidence on their mechanisms of action involve molecular interaction with estrogenic receptors, anti‐inflammatory, anti‐oxidative, antiapoptotic, autophagic inducing, and so on. phytoestrogen‐isoflavones are the major bioactive components in the Trifolium pratense that exhibit therapeutic efficacy in the case of neurodegenerative disorders. This review provides detailed molecular mechanisms targeted by phytoestrogen‐isoflavones and experimental key findings for the clinical use of prescriptions containing Trifolium pratense‐derived isoflavones for the treatment of neurodegenerative disorders.

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“…Moreover, it enhanced the expression of BDNF and the phosphorylation of CREB. PI3K inhibitor LY294002 could abolish these above effects [ 113 ]. In a rat spinal cord ischemia reperfusion injury (SCIRI) model, daidzein (10 mg/kg, intraperitoneal administration for 14 days) alleviated neuronal apoptosis, locomotor activity, and edema in SCIRI rats.…”

Section: The Protective Mechanism Of Daidzein and Daidzin Against Cer...mentioning

confidence: 99%

Therapeutic Potential and Mechanisms of Novel Simple O-Substituted Isoflavones against Cerebral Ischemia Reperfusion

Yang

Lien

Tsai

et al. 2022

IJMS

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Isoflavones have been widely studied and have attracted extensive attention in fields ranging from chemotaxonomy and plant physiology to human nutrition and medicine. Isoflavones are often divided into three subgroups: simple O-substituted derivatives, prenylated derivatives, and glycosides. Simple O-substituted isoflavones and their glycosides, such as daidzein (daidzin), genistein (genistin), glycitein (glycitin), biochanin A (astroside), and formononetin (ononin), are the most common ingredients in legumes and are considered as phytoestrogens for daily dietary hormone replacement therapy due to their structural similarity to 17-β-estradiol. On the basis of the known estrogen-like potency, these above isoflavones possess multiple pharmacological activities such as antioxidant, anti-inflammatory, anticancer, anti-angiogenetic, hepatoprotective, antidiabetic, antilipidemic, anti-osteoporotic, and neuroprotective activities. However, there are very few review studies on the protective effects of these novel isoflavones and their related compounds in cerebral ischemia reperfusion. This review primarily focuses on the biosynthesis, metabolism, and neuroprotective mechanism of these aforementioned novel isoflavones in cerebral ischemia reperfusion. From these published works in in vitro and in vivo studies, simple O-substituted isoflavones could serve as promising therapeutic compounds for the prevention and treatment of cerebral ischemia reperfusion via their estrogenic receptor properties and neuron-modulatory, antioxidant, anti-inflammatory, and anti-apoptotic effects. The detailed mechanism of the protective effects of simple O-substituted isoflavones against cerebral ischemia reperfusion might be related to the PI3K/AKT/ERK/mTOR or GSK-3β pathway, eNOS/Keap1/Nrf-2/HO-1 pathway, TLRs/TIRAP/MyD88/NFκ-B pathway, and Bcl-2-regulated anti-apoptotic pathway. However, clinical trials are needed to verify their potential on cerebral ischemia reperfusion because past studies were conducted with rodents and prophylactic administration.

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Neuroprotective Effect of Daidzein Extracted From Pueraria lobate Radix in a Stroke Model Via the Akt/mTOR/BDNF Channel

Cited by 10 publications

References 52 publications

Correlation between total phenolic and flavonoid contents and biological activities of 12 ethanolic extracts of Iranian propolis

Correlation between total phenolic and flavonoid contents and biological activities of 12 ethanolic extracts of Iranian propolis

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen‐isoflavones in neurodegenerative disorders

Therapeutic Potential and Mechanisms of Novel Simple O-Substituted Isoflavones against Cerebral Ischemia Reperfusion

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