Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats

Zhao, Jing; Zhao, Yong; Zheng, Wenjie; Lu, Youming; Feng, Gang; Yu, Shanshan

doi:10.1016/j.brainres.2008.06.117

Cited by 114 publications

(86 citation statements)

References 30 publications

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“…[4] Recent studies have shown that curcumin has neuroprotective properties. [37][38][39][40][41] In this study, we aimed to investigate the effect of curcumin treatment in SCI on the oxidant and anti-oxidant enzyme systems. Curcumin is a well-known neuroprotective agent.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant effects of curcumin in spinal cord injury in rats

Kavakli

Koca²,

Alıcı³

2011

Ulus Travma Acil Cerrahi Derg

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AMAÇBu deneysel çalışma, sıçanlarda spinal kord yaralanmasın-da curcuminin antioksidan etki yoluyla faydasını araştır-mak için yapıldı. GEREÇ VE YÖNTEMYirmi dört adet Wistar albino sıçan 3 gruba randomize edildi. Spinal kord yaralanması ağırlık düşürme modeliyle gerçekleştirildi. Grup 1'e laminektomi ardından spinal kord yaralanması uygulandı ve herhangi bir tedavi verilmedi. Grup 2'ye laminektomi ardından spinal kord yaralanması uygulandı ve curcumin verildi (200 mg/kg/gün ağızdan). Grup 3'e laminektomi ardından spinal kord yaralanması uygulandı ve metilprednizolon verildi (30 mg/kg periton içine), 24 saat sonra tüm sıçanlardan kan örnekleri alındı, sonra serum süperoksit dismutaz (SOD) ve malondialdehit (MDA) düzeyleri belirlendi ve elde edilen sonuçlar karşılaştırıldı. BULGULARCurcumin grubunda SOD düzeyi kontrol ve metilprednizolon grubundan daha yüksekti (p<0,001 ve p<0,012). Curcumin grubunda MDA düzeyi kontrol grubundan daha düşüktü (p<0,042). Benzer şekilde metilprednizolon grubunda MDA düzeyi kontrol grubundan daha düşüktü (p<0,001). SONUÇBu çalışmanın sonuçları curcuminin etkin biçimde oksidatif hasara karşı spinal kord dokularını koruduğunu gös-terir.Anahtar Sözcükler: Antioksidan; curcumin; malondialdehit; spinal kord yaralanması; süperoksit dismutaz.

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Section: Discussionmentioning

confidence: 99%

Antioxidant effects of curcumin in spinal cord injury in rats

Kavakli

Koca²,

Alıcı³

2011

Ulus Travma Acil Cerrahi Derg

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“…Evidence indicates that curcumin may act as a neuroprotective substance on postischemic outcome and behavioral deficits in rodents and this neuroprotective effect is presented by antiapoptotic action [66,74,75]. Other studies have shown that curcumin reverses the permeability of the ischemic blood-brain barrier and decreases brain edema [13,20].…”

Section: Potent Neuroprotective Activity Of Curcuminmentioning

confidence: 99%

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Pluta¹,

Bogucka‐Kocka²,

Ułamek-Kozioł³

et al. 2015

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“…Bcl-2, an inhibitor of apoptosis, prevents neuronal apoptosis by blocking the destruction of mitochondria and the subsequent release of cytochrome c and caspase activation [26] . Under the condition of hypoxic-ischemic brain injury, the outer membrane of mitochondria becomes permeable [27] , which leads to the release of cytochrome c and further promotes the activation of caspase-3, a key mediator of apoptosis [28][29][30][31] . It is activated by cleavage, and active caspase-3 leads to DNA fragmentation and eventually apoptosis [32,33] .…”

Section: Discussionmentioning

confidence: 99%

Sulforaphane protects primary cultures of cortical neurons against injury induced by oxygen-glucose deprivation/reoxygenation via antiapoptosis

Zhao

et al. 2012

Neurosci. Bull.

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Objective To determine whether sulforaphane (SFN) protects neurons against injury caused by oxygenglucose deprivation/reoxygenation (OGD/R) and, if so, to investigate the possible mechanisms. Methods Primary cultures of neurons were prepared from the cerebral cortex of 1-day-old Sprague-Dawley rats. On days 5-6 in vitro, the neurons were exposed to OGD for 1 h, followed by reoxygenation for 24 h. Cells were treated with 0, 0.1, 0.2, 0.5, 1, 2.5, or 5 µmol/L SFN, with or without 10 µmol/L LY294002, a PI3K-specific inhibitor, during OGD/R (a total of 25 h). After 24-h reoxygenation, MTT was used to assess viability and injury was assessed by Hoechst 33258/propidium iodide (PI) staining; immunofluorescence staining and Western blot were performed to detect molecular events associated with apoptosis. ResultsThe MTT assay showed that 1 µmol/L SFN significantly increased viability, and Hoechst 33258/PI staining showed that the numbers of injured neurons were reduced significantly in the SFN group. Furthermore, immunofluorescence staining and Western blot showed that SFN increased Bcl-2 and decreased cleaved caspase-3 levels. Moreover, LY294002 inhibited the phosphorylated-Akt expression evoked by SFN, decreased Bcl-2 expression and increased cleaved caspase-3 expression.Conclusion SFN protects neurons against injury from OGD/R and this effect may be partly associated with an antiapoptosis pathway.

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Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats

Cited by 114 publications

References 30 publications

Antioxidant effects of curcumin in spinal cord injury in rats

Antioxidant effects of curcumin in spinal cord injury in rats

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Sulforaphane protects primary cultures of cortical neurons against injury induced by oxygen-glucose deprivation/reoxygenation via antiapoptosis

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