Neuroprotective effect of curcumin as evinced by abrogation of rotenone-induced motor deficits, oxidative and mitochondrial dysfunctions in mouse model of Parkinson's disease

Khatri, Dharmendra Kumar; Juvekar, Archana R.

doi:10.1016/j.pbb.2016.09.002

Cited by 90 publications

(45 citation statements)

References 92 publications

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“…3). These findings correlated with the reported neuroprotective role of curcumin, such as against rotenone induced Parkinson’s disease in mice (Khatri and Juvekar, 2016) and thus provided additional mechanistic justification for using curcumin to treat neuropathic pain.…”

Section: Discussionsupporting

confidence: 78%

Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

Xiao¹,

Ding²,

Fernandez³

et al. 2017

eCM

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Current non-surgical treatments for lumbar radiculopathy [e.g. epidural steroids and Tumour necrosis factor-α (TNF-α) antagonists] are neither effective nor safe. As a non-toxic natural product, curcumin possesses an exceptional anti-inflammatory profile. We hypothesised that curcumin alleviates lumbar radiculopathy by attenuating neuroinflammation, oxidative stress and nociceptive factors. In a dorsal root ganglion (DRG) culture, curcumin effectively inhibited TNF-α-induced neuroinflammation, in a dose-dependent manner, as shown by mRNA and protein expression of IL-6 and COX-2. Such effects might be mediated via protein kinase B (AKT) and extracellular signal regulated kinase (ERK) pathways. Also, a similar effect in combating TNF-α-induced neuroinflammation was observed in isolated primary neurons. In addition, curcumin protected neurons from TNF-α-triggered excessive reactive oxygen species (ROS) production and cellular apoptosis and, accordingly, promoted mRNA expression of the anti-oxidative enzymes haem oxygenase-1, catalase and superoxide dismutase-2. Intriguingly, electronic von Frey test suggested that intraperitoneal injection of curcumin significantly abolished ipsilateral hyperalgesia secondary to disc herniation in mice, for up to 2 weeks post-surgery. Such in vivo pain alleviation could be attributed to the suppression, observed in DRG explant culture, of TNF-α-elicited neuropeptides, such as substance P and calcitonin gene-related peptide. Surprisingly, micro-computed tomography (µCT) data suggested that curcumin treatment could promote disc height recovery following disc herniation. Alcian blue/picrosirius red staining confirmed that systemic curcumin administration promoted regeneration of extracellular matrix proteins, visualised by presence of abundant newly-formed collagen and proteoglycan content in herniated disc. Our study provided pre-clinical evidence for expediting this natural, non-toxic pleiotropic agent to become a new and safe clinical treatment of radiculopathy.

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Section: Discussionsupporting

confidence: 78%

Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

Xiao¹,

Ding²,

Fernandez³

et al. 2017

eCM

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“…Other studies have also found similar improvements in motor skills measured by the rotarod test after curcumin supplementation. For example, curcumin feeding of 50, 100 and 200 mg/kg per os for 3 weeks in a mouse model of Parkinson's disease, has shown to ameliorate rotarod test deficits in a dose-dependent manner compared to non-treated counterparts 42 . Daily oral feeding of mice with the inherited peripheral neuropathy model with curcumin in 50 or 100 mg per kg bodyweight doses for 90 days has revealed improved rotarod performance compared to non-fed counterparts 43 .…”

Section: Discussionmentioning

confidence: 99%

Effects of a solid lipid curcumin particle formulation on chronic activation of microglia and astroglia in the GFAP-IL6 mouse model

Ullah

Asgarov

Venigalla

et al. 2020

Sci Rep

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Chronic glial activation is characterized by increased numbers of activated glial cells, secreting free radicals and cytotoxic cytokines, subsequently causing neuronal damage. In order to investigate the anti-inflammatory activity of Longvida ® Optimised Curcumin (LC), we fed 500 ppm of LC to 2-monthold wild type and GFAP-IL6 mice for 6 months. LC feeding led to a significant reduction in the number of Iba-1 + microglia by 26% in the hippocampus and by 48% in the cerebellum, GFAP + astrocytes by 30%, and TSPO + cells by 24% in the hippocampus and by 31% in the cerebellum of the GFAP-IL6 mice. The morphology of the cells was assessed and LC significantly decreased the dendritic length of microglia and the convex area, convex perimeter, dendritic length, nodes and number of processes of astrocytes in the hippocampus while decreasing the soma area and perimeter in the cerebellum, in LC-fed GFAP-IL6 mice. In addition, LC feeding increased pre-and postsynaptic protein levels and improved balance measured by Rotarod. Together, these data suggest that LC is able to attenuate the inflammatory pathology and ameliorate neurodegeneration and motor deficits in GFAP-IL6 mice. For patients with neuro-inflammatory disorders, LC might potentially reverse the detrimental effects of chronic glial activation.In a healthy brain, microglia and astrocytes play a key role in the normal function of the central nervous system (CNS). The inflammatory response is mediated by the activated microglia, which is considered as the hallmark of neuroinflammation. The chronic activation of microglia leads to neuronal damage through the release of various cytotoxic molecules such as cytokines, reactive oxygen intermediates, and proteinases 1 . Microglia are involved in neural development including through phagocytosis of apoptotic cells. They also influence the function of neurons and their progenitor cells 2 . Astrocytes regulate synaptic transmission, for example through re-uptake of neurontransmitters such as glutamate, and support neurons with metabolic substrates such as gluthathione and lactate 3 .Chronic microglial activation, or neuroinflammation, has been described in many neurodegenerative diseases including chronic traumatic encephalopathy, amyotrophic lateral sclerosis, Parkinson's (PD) and Alzheimer's disease (AD) 4 . For sporadic AD, surmounting histological evidence points to chronic microglial activation as a part of the disease process 1,5 . Chronic microglial activation describes long lasting, CNS-specific, aberrant glial responses that do not reproduce the classic characteristics of inflammation although they do contribute to neurodegeneration 6 . To further support the role of neuroinflammation in AD, genome-wide association studies have identified a variety of inflammation-relevant genes that are associated with AD including clusterin (CLU), complement receptor 1 (CR1) and triggering receptor expressed on myeloid cells 2 (TREM2) 7 . The role of the microglial receptor TREM2 is to activate phagocytosis or microglial survival, an...

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“…Meanwhile, curcumin inhibits astrocytic activation, and reduces iron deposition on the dopaminergic neurons. Moreover, the cognitive function is impaired in mice with PD, while curcumin treatment in mice reduces the enhanced acetylcholine esterase enzyme levels, and restores the moto deficits, improving the cognitive functions [ 145 ]. Curcumin provides protection for neurons by reducing p-p28 expression, caspase-3 activation, and toxic quinoprotein formation in 6-hydroxydopamine treated SH-SY5Y cells, ameliorating oxidative stress-related neurodegeneration, like PD [ 146 ].…”

Section: Health Benefits Of Curcuminmentioning

confidence: 99%

Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

et al. 2018

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Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protection and promotion of human health. In addition to presenting an overview of the gut metabolism of curcumin, this paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, and also intensively discusses its health benefits, including the protective or preventive effects on cancers and diabetes, as well as the liver, nervous system, and cardiovascular systems, highlighting the potential molecular mechanisms. Besides, the beneficial effects of curcumin on human are further stated based on clinical trials. Considering that there is still a debate on the beneficial effects of curcumin, we also discuss related challenges and prospects. Overall, curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases. We hope this comprehensive and updated review will be helpful for promoting human-based studies to facilitate its use in human health and diseases in the future.

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Neuroprotective effect of curcumin as evinced by abrogation of rotenone-induced motor deficits, oxidative and mitochondrial dysfunctions in mouse model of Parkinson's disease

Cited by 90 publications

References 92 publications

Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors

Effects of a solid lipid curcumin particle formulation on chronic activation of microglia and astroglia in the GFAP-IL6 mouse model

Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

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