Neuroprotective effect of cobalt chloride on hypobaric hypoxia-induced oxidative stress

Shrivastava, Kalpana; Shukla, Dhananjay; Bansal, Anju; Sairam, M.; Banerjee, P. K.; Ilavazhagan, G.

doi:10.1016/j.neuint.2007.07.005

Cited by 46 publications

(45 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although we did observe a robust histologic protective effect of CoCl 2 preconditioning against total lesion volume and cortical injury in the present study, the grip traction test was the only functional test that was improved by CoCl 2 treatment. Recently, CoCl 2 was shown to produce in vivo brain protection against hypobaric hypoxia (37); however, the present study is the first to indicate that CoCl 2 can produce a long-term functional and histologic protection up to 5 wk after HI injury.…”

Section: Discussioncontrasting

confidence: 62%

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

et al. 2008

View full text Add to dashboard Cite

ABSTRACT:Preconditioning with hypoxia and hypoxia-mimetic compounds cobalt chloride (CoCl 2 ) and desferrioxamine (DFX) protects against hypoxic-ischemic (HI) injury in neonatal rat brain. We examined long-term functional and protective actions of preconditioning induced by hypoxia, CoCl 2 and DFX in a neonatal rat model of HI. Postnatal day six rat pups were exposed to preconditioning with hypoxia (8% oxygen) or injections of CoCl 2 , DFX or saline vehicle and 24 h later rats underwent HI or sham surgery. Behavioral tests were performed and at the conclusion of experiments, brains removed for morphologic analyses. HI resulted in a large unilateral lesion in the ipsilateral hemisphere compared with sham control rats. All preconditioning treatments significantly reduced the total lesion volume. Behavioral deficits were observed in HI rats compared with sham controls. The reduction in forelimb grasping strength in HI rats was attenuated by preconditioning with hypoxia, CoCl 2 and DFX. HI increased the number of foot faults in a grid-walking test and resulted in forelimb asymmetry in the cylinder test. Only preconditioning with hypoxia reversed all three functional deficits after HI. These findings indicate that preconditioning, especially when induced by hypoxia, has the potential to minimize the morphologic and functional effects of neonatal HI injury. (Pediatr Res 63: 620-624, 2008)

show abstract

Section: Discussioncontrasting

confidence: 62%

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

et al. 2008

View full text Add to dashboard Cite

show abstract

“…We have earlier reported that supplementation of CoCl 2 (12.5 mg cobalt kg -1 BW, 7days) promotes tolerance and facilitates acclimatization to hypobaric hypoxia (Shrivastava et al, 2008a). It can attenuate hypobaric hypoxia induced oxidative stress (Shrivastava et al, 2008c) and vascular leakage in brain (Shrivastava et al, 2008b). The possibility of use of cobalt either in the form of a drug or neutraceutical prompted us to evaluate the safety of this standardized dose (12.5 mg cobalt kg -1 BW, 7days).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, we have revealed the neuroprotective effect of oral supplementation of CoCl 2 (12.5 mg cobalt kg -1 BW for seven days) on hypobaric hypoxia induced oxidative stress (Shrivastava et al, 2008c) and its efficiency in facilitating acclimatization to hypobaric hypoxia (Shrivastava et al, 2008a). Moreover, we have also studied the efficacy of cobalt preconditioning in preventing hypobaric hypoxia induced vascular leakage (Shrivastava et al, 2008b).…”

Section: Introductionmentioning

confidence: 99%

Sub-chronic oral toxicity study in Sprague-Dawley rats with hypoxia mimetic cobalt chloride towards the development of promising neutraceutical for oxygen deprivation

Shrivastava

Bansal

Singh

et al. 2010

Experimental and Toxicologic Pathology

Self Cite

View full text Add to dashboard Cite

-chronic oral toxicity study in SpragueDawley rats with hypoxia mimetic cobalt chloride towards the development of promising neutraceutical for oxygen deprivation, Experimental and Toxicologic Pathology, doi:10.1016Pathology, doi:10. /j.etp.2009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 3. Biologicals E. Ltd. Hyderabad, India. *Corresponding Author A c c e p t e d m a n u s c r i p t 2 AbstractThe present study evaluates the toxicity from sub-chronic administration of CoCl 2 (12.5 mg cobalt kg -1 BW for seven days) to male Sprague-Dawley rats in view of the beneficial effects of CoCl 2 in animals and for developing efficacious therapeutic regimen in humans. 32 rats weighing 200±25g were used for all experiments. Blood was collected for hematological and biochemical analysis and various organs were dissected after perfusion of animals under anesthesia for other analyses. Mean feed consumption and feed conversion efficiency values were comparable across all study groups; however, Hematological analysis depicted a significant increase in hemoglobin, hematocrit and RBC in the entire cobalt supplemented groups which are a component of its beneficial effect. There was a significant increase in monocytes, Granulocytes and WBC after 1h and 24h which were comparable with control after 7 days. Other biochemical analyses also showed no change with respect to control. Though the metal content increased significantly in liver initially (1h and 24h) after treatment, it was equivalent to control after 7 days.Moreover, histopathological analysis revealed no evidence of changes that could be attributed to cobalt pretreatment. It is therefore reasonable to conclude that the present study supports further use of the present dose of CoCl 2 which was found to be nontoxic.

show abstract

“…Cobalt chloride supplementation at low concentration improved cardiac contractile functions in hypoxia-reoxygenation in rats (8). Shrivastava et al (25) have shown that Co preconditioning improves hypoxic tolerance of rats exposed to severe hypobaric hypoxia.…”

Section: Introductionmentioning

confidence: 98%

Modulators of K_ATP channels in the prevention of oxidative stress and antioxidant capacity improvement in the rat heart with different resistance to hypoxia upon cobalt treatment

Kurhaluk¹,

Tkachenko²

2016

Journal of Veterinary Research

View full text Add to dashboard Cite

Introduction:The main goal of the study was to investigate the effect of KATP channel modulators on development of oxidative stress in the heart of rats showing different resistance to hypoxia. Material and Methods: The study has been performed on rats showing high-(HR) or low-resistance (LR) to hypoxia under modulators of ATP-sensitive potassium (KATP) channel opener pinacidil (0.06 mg/kg) and blocker glibenclamide (1 mg/kg) upon cobalt (Co) treatment (30 mg of cobalt chloride/kg b.w., 3 h). Changes in the oxidative stress parameters of the heart tissue, such as lipid peroxidation (LPO), level of oxidatively modified protein (OMP), and antioxidant defence system (superoxide dismutase -SOD, catalase -CAT, glutathione peroxidase -GPx, glutathione reductase -GR) as well as total antioxidant activity (TAA) were analysed. Results: Co treatment caused a significant decrease in SOD and CAT activity in the heart of LR rats and GPx activity in HR rats. It also led to a decrease in OMP level in the heart of rats with HR in comparison with controls. Conclusion: The obtained results suggest that individual resistance to hypoxia plays a crucial role in Co actions and provides evidence that the effects of KATP channel opener pinacidil in the heart are mediated through different pathways of the antioxidative system, depending on the individual resistance to hypoxia. Pinacidil exerts a protective effect on the heart tissue by preventing the LPO decrease and significantly reducing OMP levels, as well as increasing TTA in rats with LR.

show abstract

Neuroprotective effect of cobalt chloride on hypobaric hypoxia-induced oxidative stress

Cited by 46 publications

References 47 publications

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

Sub-chronic oral toxicity study in Sprague-Dawley rats with hypoxia mimetic cobalt chloride towards the development of promising neutraceutical for oxygen deprivation

Modulators of K_ATP channels in the prevention of oxidative stress and antioxidant capacity improvement in the rat heart with different resistance to hypoxia upon cobalt treatment

Contact Info

Product

Resources

About

Neuroprotective effect of cobalt chloride on hypobaric hypoxia-induced oxidative stress

Cited by 46 publications

References 47 publications

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

Long-Term Functional and Protective Actions of Preconditioning With Hypoxia, Cobalt Chloride, and Desferrioxamine Against Hypoxic-Ischemic Injury in Neonatal Rats

Sub-chronic oral toxicity study in Sprague-Dawley rats with hypoxia mimetic cobalt chloride towards the development of promising neutraceutical for oxygen deprivation

Modulators of KATP channels in the prevention of oxidative stress and antioxidant capacity improvement in the rat heart with different resistance to hypoxia upon cobalt treatment

Contact Info

Product

Resources

About

Modulators of K_ATP channels in the prevention of oxidative stress and antioxidant capacity improvement in the rat heart with different resistance to hypoxia upon cobalt treatment