Neuroprotective effect of Berberine Nanoparticles Against Seizures in Pentylenetetrazole Induced Kindling Model of Epileptogenesis: Role of Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms

Saha, Lekha; Kumari, Puja; Rawat, Kajal; Gautam, Vipasha; Sandhu, Arushi; Singh, Neha; Bhatia, Alka; Bhattacharya, Saurav; Sinha, Vivek Ranjan; Chakrabarti, Amitava

doi:10.1007/s11064-023-03967-z

Cited by 6 publications

(5 citation statements)

References 68 publications

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“…Crucially, safety evaluations of the nanoparticle system yielded no evidence of toxicity or behavioral modification, affirming the biocompatibility of B2 ( El-Nahas et al, 2023 ). This finding substantiates the nanoparticle system’s potential as a safe vehicle for delivering AED, holding promise for future clinical translation ( Saha et al, 2023 ).…”

Section: Alkaloid Therapy For Epilepsy: Challenges and Opportunitiessupporting

confidence: 66%

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

Li,

Lin,

Duan

2024

Front. Pharmacol.

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Section: Alkaloid Therapy For Epilepsy: Challenges and Opportunitiessupporting

confidence: 66%

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

Li,

Lin,

Duan

2024

Front. Pharmacol.

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“…[Ranunculaceae; coptidis rhizoma]. It exhibits pharmacological properties, including anti-inflammatory, cardioprotective, and hypoglycemic effects ( Miao and Cui, 2022 ; Saha et al, 2023 ). Intestinal flora enhances the bioavailability of orally administered BBR.…”

Section: Therapeutic Intervention For Amd With Tcmmentioning

confidence: 99%

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Yu,

Liu,

Meng

2024

Front. Pharmacol.

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The pathogenesis of age-related macular degeneration (AMD), a degenerative retinopathy, remains unclear. Administration of anti-vascular endothelial growth factor agents, antioxidants, fundus lasers, photodynamic therapy, and transpupillary warming has proven effective in alleviating symptoms; however, these interventions cannot prevent or reverse AMD. Increasing evidence suggests that AMD risk is linked to changes in the composition, abundance, and diversity of the gut microbiota (GM). Activation of multiple signaling pathways by GM metabolites, including lipopolysaccharides, oxysterols, short-chain fatty acids (SCFAs), and bile acids (BAs), influences retinal physiology. Traditional Chinese medicine (TCM), known for its multi-component and multi-target advantages, can help treat AMD by altering GM composition and regulating the levels of certain substances, such as lipopolysaccharides, reducing oxysterols, and increasing SCFA and BA contents. This review explores the correlation between GM and AMD and interventions for the two to provide new perspectives on treating AMD with TCM.

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“…[ 263 ] These nanodrugs primarily function by inhibiting and restoring neurological damages and functional impairments, [ 263 ] suppressing oxidative stress, inflammation, hyperexcitability and apoptosis. [ 195 , 260 ] Integrating clinical antiepileptic drugs with antioxidative and anti‐inflammatory molecules in nanoplatforms with BBB‐penetrating and on‐demand drug‐releasing capabilities may shed light on the effective treatment of epilepsy.…”

Section: Pd Approaches: Nanomedicines For Treating Anesthesia‐related...mentioning

confidence: 99%

“…[189] In addition to nanocarriers loaded with clinical antiepileptic drugs, various nanodrugs with antioxidative and antiinflammatory bioactivity have proven their effectiveness in seizure treatment. These include herbal molecules (e.g., berberine, resveratrol, and rutin-loaded NPs), [195,260,261] antioxidative nanozymes (e.g., selenium NPs), [262] and extracellular vesicles containing antioxidative microRNA. [263] These nanodrugs primarily function by inhibiting and restoring neurological damages and functional impairments, [263] suppressing oxidative stress, inflammation, hyperexcitability and apoptosis.…”

Section: Epilepsymentioning

confidence: 99%

Nanotherapeutics for Alleviating Anesthesia‐Associated Complications

Lu,

Wei,

Shi

et al. 2024

Advanced Science

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Current management of anesthesia‐associated complications falls short in terms of both efficacy and safety. Nanomaterials with versatile properties and unique nano‐bio interactions hold substantial promise as therapeutics for addressing these complications. This review conducts a thorough examination of the existing nanotherapeutics and highlights the strategies for developing prospective nanomedicines to mitigate anesthetics‐related toxicity. Initially, general, regional, and local anesthesia along with the commonly used anesthetics and related prevalent side effects are introduced. Furthermore, employing nanotechnology to prevent and alleviate the complications of anesthetics is systematically demonstrated from three aspects, that is, developing 1) safe nano‐formulization for anesthetics; 2) nano‐antidotes to sequester overdosed anesthetics and alter their pharmacokinetics; 3) nanomedicines with pharmacodynamic activities to treat anesthetics toxicity. Finally, the prospects and challenges facing the clinical translation of nanotherapeutics for anesthesia‐related complications are discussed. This work provides a comprehensive roadmap for developing effective nanotherapeutics to prevent and mitigate anesthesia‐associated toxicity, which can potentially revolutionize the management of anesthesia complications.

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Neuroprotective effect of Berberine Nanoparticles Against Seizures in Pentylenetetrazole Induced Kindling Model of Epileptogenesis: Role of Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms

Cited by 6 publications

References 68 publications

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Nanotherapeutics for Alleviating Anesthesia‐Associated Complications

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