Neuroprotective effect of Alpinia galanga (L.) fractions on Aβ(25–35) induced amnesia in mice

Singh, Jagjeet; Alagarsamy, V.; Diwan, Prakash V.; Kumar, S. Sathesh; Nisha, J.C.; Reddy, Y. V. R.

doi:10.1016/j.jep.2011.08.048

Cited by 45 publications

(9 citation statements)

References 45 publications

(34 reference statements)

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“…Of course, these factors sometimes do not stand alone in AD. For example, Alpinia galanga (L.) fractions play the neuroprotective effect on Aβ (25‐35)‐induced amnesia in mice via the increment in Na + , K + ‐ATPase, the improvement of antioxidant activity, and the decrease of AChE level to improve the cognition by enhancing cholinergic transmission . On the whole, these studies confirm that altered ion homeostasis disturbed by neuro‐degenerations play an essential role in pathogenesis of experimental AD, suggesting that the alterations of membrane Na + ‐K + ‐ATPase might be a common pathway in AD.…”

Section: Discussionmentioning

confidence: 68%

Na⁺‐K⁺‐ATPase, a potent neuroprotective modulator against Alzheimer disease

Zhang

Sun

Pan

et al. 2012

Fundamemntal Clinical Pharma

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Alzheimer disease (AD) is a neurodegenerative disorder clinically characterized by progressive cognitive and memory dysfunction, which is the most common form of dementia. Although the pathogenesis of neuronal injury in AD is not clear, recent evidences suggest that Na⁺-K⁺-ATPase plays an important role in AD, and may be a potent neuroprotective modulator against AD. This review aims to provide readers with an in-depth understanding of Na⁺-K⁺-ATPase in AD through these modulations of some factors that are as follows, which leads to the change of learning and memory in the process of AD. 1. The deficiency in Na⁺, K⁺-ATPase α1, α2 and α3 isoform genes induced learning and memory deficits, and α isoform was evidently changed in AD, revealing that Na⁺, K⁺-ATPase α isoform genes may play an important role in AD. 2. Some factors, such as β-amyloid, cholinergic and oxidative stress, can modulate learning and memory in AD through the mondulation of Na⁺-K⁺-ATPase activity. 3. Some substances, such as Zn, s-Ethyl cysteine, s-propyl cysteine, citicoline, rivastigmine, Vit E, memantine, tea polyphenol, curcumin, caffeine, Alpinia galanga (L.) fractions, and Bacopa monnieri could play a role in improving memory performance and exert protective effects against AD by increasing expression or activity of Na⁺, K⁺-ATPase.

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Section: Discussionmentioning

confidence: 68%

Na⁺‐K⁺‐ATPase, a potent neuroprotective modulator against Alzheimer disease

Zhang

Sun

Pan

et al. 2012

Fundamemntal Clinical Pharma

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“… 13 Previous reports proved that strong antioxidants increases the Na + , K + -ATPases activities by decreasing AChE (Acetyl cholinesterase) levels and improves the cognition by enhancing cholinergic transmission. 14 …”

Section: Introductionmentioning

confidence: 99%

Role of Lactobacillus plantarum MTCC1325 in membrane-bound transport ATPases system in Alzheimer’s disease-induced rat brain

Nimgampalle¹,

Praveen²,

Yellamma³

2016

Bioimpacts

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Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder, clinically characterized by memory dysfunction and progressive loss of cognition. No curative therapeutic or drug is available for the complete cure of this disease. The present study was aimed to evaluate the efficacy of Lactobacillus plantarum MTCC1325 in ATPases activity in the selected brain regions of rats induced with Alzheimer’s. Methods: For the study, 48 healthy Wistar rats were divided into four groups: group I as control group, group II as AD model (AD induced by intraperitoneal injection of D-Galactose, 120 mg/kg body weight for 6 weeks), group III as normal control rats which were orally administered only with L. plantarum MTCC1325 for 60 days, and group IV where the AD-induced rats simultaneously received oral treatment of L. plantarum MTCC1325 (10ml/kg body weight, 12×108 CFU/mL) for 60 days. The well known membrane bound transport enzymes including Na+, K+-ATPases, Ca2+-ATPases, and Mg2+-ATPases were assayed in the selected brain regions of hippocampus and cerebral cortex in all four groups of rats at selected time intervals. Results: Chronic injection of D-Galactose caused lipid peroxidation, oxidative stress, and mitochondrial dysfunction leading to the damage of neurons in the brain, finally bringing a significant decrease (-20%) in the brain total membrane bound ATPases over the controls. Contrary to this, treatment of AD-induced rats with L. plantarum MTCC1325 reverted all the constituents of ATPase enzymes to near normal levels within 30 days. Conclusion: Lactobacillus plantarum MTCC1325 exerted a beneficial action on the entire ATPases system in AD-induced rat brain by delaying neurodegeneration.

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“…In addition to chemical pharmacological agents, bioactive extracts derived from natural products are attracting increasing attention in the search for new effective agents for the treatment of AD. Examples of such extracts that, when administered, led to inhibition of Aβ aggregation and related downstream pathological responses include aged garlic extract (AGE) [12] , Ginkgo biloba extract (EGb761) [13] , fungal endophytic extracts of Malaysian medicinal plants [14] , Alpinia galanga (L.) fractions [15] , Yokukansan extract [16] , coffee extract [17] , Samjunghwan extract [18] , Paeonia suffruticosa extract [19] , GEPT (a combination of extracts of ginseng, Epimedium , Polygala and tubers of the Curcuma genus) [20] .…”

Section: Introductionmentioning

confidence: 99%

Effects of Secondary Metabolite Extract from Phomopsis occulta on β-Amyloid Aggregation

Zhang

Williamson

et al. 2014

PLoS ONE

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Inhibition of β-amyloid (Aβ) aggregation is an attractive therapeutic and preventive strategy for the discovery of disease-modifying agents in Alzheimer's disease (AD). Phomopsis occulta is a new, salt-tolerant fungus isolated from mangrove Pongamia pinnata (L.) Pierre. We report here the inhibitory effects of secondary metabolites from Ph. occulta on the aggregation of Aβ42. It was found that mycelia extracts (MEs) from Ph. occulta cultured with 0, 2, and 3 M NaCl exhibited inhibitory activity in an E. coli model of Aβ aggregation. A water-soluble fraction, ME0-W-F1, composed of mainly small peptides, was able to reduce aggregation of an Aβ42-EGFP fusion protein and an early onset familial mutation Aβ42E22G-mCherry fusion protein in transfected HEK293 cells. ME0-W-F1 also antagonized the cytotoxicity of Aβ42 in the neural cell line SH-SY5Y in dose-dependent manner. Moreover, SDS-PAGE and FT-IR analysis confirmed an inhibitory effect of ME0-W-F1 on the aggregation of Aβ42 in vitro. ME0-W-F1 blocked the conformational transition of Aβ42 from α-helix/random coil to β-sheet, and thereby inhibited formation of Aβ42 tetramers and high molecular weight oligomers. ME0-W-F1 and other water-soluble secondary metabolites from Ph. occulta therefore represent new candidate natural products against aggregation of Aβ42, and illustrate the potential of salt tolerant fungi from mangrove as resources for the treatment of AD and other diseases.

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Neuroprotective effect of Alpinia galanga (L.) fractions on Aβ(25–35) induced amnesia in mice

Cited by 45 publications

References 45 publications

Na⁺‐K⁺‐ATPase, a potent neuroprotective modulator against Alzheimer disease

Na⁺‐K⁺‐ATPase, a potent neuroprotective modulator against Alzheimer disease

Role of Lactobacillus plantarum MTCC1325 in membrane-bound transport ATPases system in Alzheimer’s disease-induced rat brain

Effects of Secondary Metabolite Extract from Phomopsis occulta on β-Amyloid Aggregation

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Neuroprotective effect of Alpinia galanga (L.) fractions on Aβ(25–35) induced amnesia in mice

Cited by 45 publications

References 45 publications

Na+‐K+‐ATPase, a potent neuroprotective modulator against Alzheimer disease

Na+‐K+‐ATPase, a potent neuroprotective modulator against Alzheimer disease

Role of Lactobacillus plantarum MTCC1325 in membrane-bound transport ATPases system in Alzheimer’s disease-induced rat brain

Effects of Secondary Metabolite Extract from Phomopsis occulta on β-Amyloid Aggregation

Contact Info

Product

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Na⁺‐K⁺‐ATPase, a potent neuroprotective modulator against Alzheimer disease

Na⁺‐K⁺‐ATPase, a potent neuroprotective modulator against Alzheimer disease