Neuroprotective Effect of a New Taurinamide Derivative — Taurepar

Крылова, И. Б.; Bulion, Valentina V.; Gavrovskaya, L. K.; Selina, Elena N.; Kuznetzova, Nataliya N.; Sapronov, N. S.

doi:10.1007/978-0-387-33504-9_62

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…It also restored the antioxidant system, regulated free radical generation and elevated animal survivability by 40%. TAU-15 also displayed an ameliorating effect on compressed spinal cords [142].…”

Section: Neuropharmacological Potential Of Taurine Analogsmentioning

confidence: 99%

Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms

et al. 2019

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Taurine is a sulfur-containing amino acid and known as semi-essential in mammals and is produced chiefly by the liver and kidney. It presents in different organs, including retina, brain, heart and placenta and demonstrates extensive physiological activities within the body. In the several disease models, it attenuates inflammation- and oxidative stress-mediated injuries. Taurine also modulates ER stress, Ca 2+ homeostasis and neuronal activity at the molecular level as part of its broader roles. Different cellular processes such as energy metabolism, gene expression, osmosis and quality control of protein are regulated by taurine. In addition, taurine displays potential ameliorating effects against different neurological disorders such as neurodegenerative diseases, stroke, epilepsy and diabetic neuropathy and protects against injuries and toxicities of the nervous system. Several findings demonstrate its therapeutic role against neurodevelopmental disorders, including Angelman syndrome, Fragile X syndrome, sleep-wake disorders, neural tube defects and attention-deficit hyperactivity disorder. Considering current biopharmaceutical limitations, developing novel delivery approaches and new derivatives and precursors of taurine may be an attractive option for treating neurological disorders. Herein, we present an overview on the therapeutic potential of taurine against neurological disorders and highlight clinical studies and its molecular mechanistic roles. This article also addresses the neuropharmacological potential of taurine analogs.

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Section: Neuropharmacological Potential Of Taurine Analogsmentioning

confidence: 99%

Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms

et al. 2019

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“…Results show greater tissue sparing which translates into less functional deficit [149]. This sulfur amino acid found endogenously in humans exerts neuroprotective effects by scrubbing ROS and downregulating the expression of proinflammatory mediators such as tumor necrosis factor-alpa (TNF-α) [151,152]. Taurine is another agent that has received little attention.…”

Section: Other Therapiesmentioning

confidence: 99%

Pharmacological Neuroprotection for Acute Spinal Cord Injury

Mestre

Balanzá

Ibarra

2014

Recent Advances in Medicinal Chemistry

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“…In this study, where a brain ischemia situation was simulated through the occlusion of the common carotid arteries, TAU-15 presented a variety of effects: It activated the aerobic oxidation of carbohydrates, improving the energy metabolism; inhibited the hyperactivation of lipid peroxidation under ischemia conditions; restored the antioxidant system, regulating the generation of free radicals; and increase animal lifetime by 40%. In addition to the neuroprotective properties of TAU-15, it is claimed that besides the aforementioned actions, taurepar also has a positive effect in spinal cord compression [48]. …”

Section: Prevention Of Alzheimer’s and Neuroprotectionmentioning

confidence: 99%

Advances in Drug Design Based on the Amino Acid Approach: Taurine Analogues for the Treatment of CNS Diseases

et al. 2012

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Amino acids are well known to be an important class of compounds for the maintenance of body homeostasis and their deficit, even for the polar neuroactive aminoacids, can be controlled by supplementation. However, for the amino acid taurine (2-aminoethanesulfonic acid) this is not true. Due its special physicochemical properties, taurine is unable to cross the blood-brain barrier. In addition of injured taurine transport systems under pathological conditions, CNS supplementation of taurine is almost null. Taurine is a potent antioxidant and anti-inflammatory semi-essential amino acid extensively involved in neurological activities, acting as neurotrophic factor, binding to GABA A/glycine receptors and blocking the excitotoxicity glutamate-induced pathway leading to be a neuroprotective effect and neuromodulation. Taurine deficits have been implicated in several CNS diseases, such as Alzheimer’s, Parkinson’s, epilepsy and in the damage of retinal neurons. This review describes the CNS physiological functions of taurine and the development of new derivatives based on its structure useful in CNS disease treatment.

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Neuroprotective Effect of a New Taurinamide Derivative — Taurepar

Cited by 5 publications

References 3 publications

Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms

Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms

Pharmacological Neuroprotection for Acute Spinal Cord Injury

Advances in Drug Design Based on the Amino Acid Approach: Taurine Analogues for the Treatment of CNS Diseases

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