Neuroprotective Diterpenes from the Fruiting Body of Antrodia camphorata

Abstract

Three new compounds, 19-hydroxylabda-8(17)-en-16,15-olide (1), 3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (2), and 13-epi-3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (3), together with four known compounds, 19-hydroxylabda-8(17),13-dien-16,15-olide (4), 14-deoxy-11,12-didehydroandrographolide (5), 14-deoxyandrographolide, and pinusolidic acid, were isolated from the fruiting bodies of Antrodia camphorata. The structures of compounds 1-3 were elucidated by the analysis of their spectroscopic data. The in vitro neuroprotective activity of all compounds was evaluated, and compounds 1-5 protected neurons from Abeta damage by 39.2, 35.0, 36.7, 30.6, and 27.0%, respectively, at concentrations between 5 and 20 microM.

Taiwanofungus camphoratusActivates Peroxisome Proliferator-Activated Receptors and Induces Hypotriglyceride in Hypercholesterolemic Rats

“…Although the active compounds wait to be further identified, several terpenoids, such as geraniol, farnesol, and geranylgeraniol, have been confirmed to activate PPAR and its target gene expression. 32) Since several sesquiterpenes, steroids, triterpenoids, and diterpenoids have been found in abundance in the fruiting body of T. camphoratus, 33) it is very likely that the extracts of T. camphoratus activated PPAR mediated by its terpenoid constituents or other steroid constituents. However, we also found that the solid-state culture of T. camphoratus had less effect on reducing the serum glucose and triglyceride levels than the wild fruiting bodies of T. camphoratus.…”

DPPH Radical Scavenging and Semicarbazide-Sensitive Amine Oxidase Inhibitory and Cytotoxic Activities ofTaiwanofungus camphoratus(Chang-Chih)

“…The extractable HWS content was similar in W-CC and SSC-CC, and higher than in LSC-CC. Several triterpenoids were isolated and identified in methanolic (or ethanolic) extracts of W-CC, [25][26][27][28] and Chen et al 8) have reported that HWS and ethanolic extracts in SSC-CC contained triterpenoids that are found in W-CC.…”

Cyclodextrin‐modified capillary electrophoresis for achiral and chiral separation of ergostane and lanostane compounds extracted from the fruiting body of Antrodia camphorata

“…This feature allows its application as a charged chiral selector over a wide pH range [2][3][4][5][6][7][8][9][10][11][12]. Except for the switching between AC1 and AC4, increasing pH from 7 to 9.3 largely unaffected the migration order of the other isolates.…”

“…It has also been used in the formulation of nutraceuticals and functional foods in Taiwan to enhance the immune system and liver function [1]. To date, this edible fungus exhibits several important biological activities: anticancer [2][3][4][5], antihepatotoxic [6,7], antihypertensive [8], anti-inflammatory [9,10], antioxidant [11], and neuroprotective activities [12]. A. camphorata inhibits lipopolysaccharide/inteferon (LPS/ IFN)-g-induced inflammatory mediator production in macrophages, as well as tumor cell proliferation [13].…”

“…A. camphorata inhibits lipopolysaccharide/inteferon (LPS/ IFN)-g-induced inflammatory mediator production in macrophages, as well as tumor cell proliferation [13]. Previous phytochemical investigations on A. camphorata have resulted in the isolation of diterpenoids, triterpenoids, sesquiterpene lactone, benzenoids, and polysaccharides [10,12,[14][15][16][17][18][19][20]. To date, three triterpenoids named antcin A (AC6), antcin B (AC3), and antcin C (AC7) with ergostane skeletons in the fruiting body of A. camphorata were first isolated and identified [16].…”