Neuroprotective benefits of grape seed and skin extract in a mouse model of Parkinson’s disease

Youssef, Sarah Ben; Brisson, G. J.; Doucet-Beaupré, Hélène; Castonguay, Anne-Marie; Gora, Charles; Amri, Mohamed; Lévesque, Martin

doi:10.1080/1028415x.2019.1616435

Cited by 42 publications

(24 citation statements)

References 61 publications

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“…Under ischemic conditions, neuroprotective effects, reducing brain damage, coupled with an anti-apoptotic activity and proteome preservation have been reported in animals pre-treated with grape seed extracts [ 66 , 67 ]. The role of grape seed extracts in attenuating inflammation and delaying the development of Alzheimer’s or acting as a neuroprotection agent in Parkinson’s disease have been reported [ 68 , 69 ]. In rats and mice, grape seed extract was suggested to improve conditions associated with metabolic syndrome [ 70 , 71 , 72 ].…”

Section: Grapes Seeds and Seed Extracts: Natural Sources Of Nutrmentioning

confidence: 99%

Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Martín

Grao‐Cruces

Millán-Linares

et al. 2020

Foods

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Wine production is an ancient human activity that generates several by-products, which include some constituents known for their potential in health care and for their role in the food or cosmetic industries. Any variety of grape (Vitis vinifera L.) contains nutrients and bioactive compounds available from their juice or solid parts. Grape seed extract has demonstrated many activities in disease prevention, such as antioxidant effects, which make it a potential source of nutraceuticals. Grape seed is a remarkable winery industry by-product due to the bioactivity of its constituents. Methods for recovery of oil from grape seeds have evolved to improve both the quantity and quality of the yield. Both the lipophilic and hydrophilic chemicals present in the oil of V. vinifera L. make this wine by-product a source of natural nutraceuticals. Food and non-food industries are becoming novel targets of oil obtained from grape seeds given its various properties. This review focuses on the advantages of grape seed oil intake in our diet regarding its chemical composition in industries not related to wine production and the economic and environmental impact of oil production.

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Section: Grapes Seeds and Seed Extracts: Natural Sources Of Nutrmentioning

confidence: 99%

Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Martín

Grao‐Cruces

Millán-Linares

et al. 2020

Foods

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“…Human neuroblastoma SH-SY5Y cells (oxysterol induced) Quercetin ↓ TLR4 signaling [14] Human PBMC (oxLDL-induced) Quercetin ↓ TLR2 and TLR4 expressions, NF-κB activation, inflammatory enzymes activity [15] Human astrocytes (LPS-induced) Anthocyanins ↓ IL-6 secretion (low LPS and anthocyanin dose); ↑ IL-6 secretion (high anthocyanin dose in LPS absence) [16] Mouse BV2 microglial cells (LPS-induced) Blueberry extract ↓ NO and TNF-α release, iNOS and COX-2 expressions, NF-κB nuclear translocation [17][18][19] Mouse BV2 microglial cells (LPS-induced) Anthocyanins ↓ NO, PGE2, TNF-α and IL-1β release, iNOS and COX-2 expressions, NF-κB nuclear translocation [20,21] Mouse microglial cells (LPS/IFN-γ-induced) Anthocyanins ↓ NO and TNF-α release, iNOS expression [22] Rat HAPI microglial cells (LPS-induced) Tart cherry extract ↓ NO and TNF-α release, COX-2 expression; ↔ iNOS expression [23] Rat astrocytes (LPS-induced) Lingonberry extract ↓ ROS production [24] Animal Mouse model (PD) GSSE ↓ ROS production, inflammatory markers [25] Mouse model (LPS and Aβ-induced microglia neuroinflammation) RES ↓ TLR4, NF-κB and cytokine secretion [26] Mouse model (LPS-impaired adult hippocampal neurogenesis) EGCG ↓ TLR4 signaling [27] Mouse model (LPS-treated) Anthocyanins ↓ NF-kB, TNF-α, and IL-1β levels [28] Mouse model (LPS-treated) PSPC ↓ TNF-α, IL-6 and IL-1β overproduction, NF-kB activation [29] Mouse model (LPS-treated) Anthocyanins ↓ ROS production, NF-kB activation, TNF-α, and IL-1β levels [30] Mouse model (LPS-treated) Anthocyanins ↓ TNF-α, and IL-1β increase; ↑ IL-10 expression [31] Mouse model (high-fat diet) PSPC ↓ iNOS, COX-2, TNF-α, IL-1β and IL-6 expressions, p38 MAPK and NF-kB activation; ↑ IL-10 levels [32] Rat model (MCAO/R) Anthocyanins ↓ TNF-α, IL-6 and IL-1β levels, NF-kB and NLRP3 expressions [33] Human Subjects with AD RES ↓ plasma pro-inflammatory markers [34] ↑: increase; ↓: decrease; ↔: insignificant change; Aβ: beta-amyloid; AD: Alzheimer's disease; COX: cyclooxygenase; EGCG: epigallocatechin gallate; GSSE: grape seed and skin extract; IFN-γ: interferon gamma; IL: interleukin; iNOS: inducible nitric oxide synthase; LDL: low-density lipoprotein; LPS: lipopolysaccharide; MAPK: mitogen-activated protein kinase; MCAO/R: middle cerebral artery occlusion/reperfusion; NF-κB: nuclear factor kappa B; NLRP: NOD-like receptor protein; NO: nitric oxide; ox: oxidized; PBMC: peripheral blood mononuclear cell; PD: Parkinson's disease; PGE2: prostaglandin E2; PSPC: purple sweet potato color; RES: resveratrol; ROS: reactive oxygen...…”

Section: Model Of Study Agent Effects Referencementioning

confidence: 99%

Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis

et al. 2020

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Oxidative stress plays an important role in the onset as well as the progression of inflammation. Without proper intervention, acute inflammation could progress to chronic inflammation, resulting in the development of inflammatory diseases. Antioxidants, such as polyphenols, have been known to possess anti-oxidative properties which promote redox homeostasis. This has encouraged research on polyphenols as potential therapeutics for inflammation through anti-oxidative and anti-inflammatory pathways. In this review, the ability of polyphenols to modulate the activation of major pathways of inflammation and oxidative stress, and their potential to regulate the activity of immune cells are examined. In addition, in this review, special emphasis has been placed on the effects of polyphenols on inflammation in the brain–liver–gut axis. The data derived from in vitro cell studies, animal models and human intervention studies are discussed.

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“…In a murine model of PD, rasagiline, an inhibitor of dopamine metabolizing monoamine oxidase B, synergized with polyphenols in promoting survival of the dopaminergic nigrostriatal pathway [173][174][175]. In this context, a Vitis vinifera red grape seed and skin extract (GSSE) exhibited in vitro and in vivo neuroprotective activity in a mouse model of PD [176]. GSSE protected dopamine neurons from neurotoxin 6-hydroxydopamine (6-OHDA) damage, reducing apoptosis, ROS production, and inflammatory markers.…”

Section: Neurodegenerationmentioning

confidence: 99%

Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies

Magrone

Russo

et al. 2019

Antioxidants

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In this review, special emphasis will be placed on red grape polyphenols for their antioxidant and anti-inflammatory activities. Therefore, their capacity to inhibit major pathways responsible for activation of oxidative systems and expression and release of proinflammatory cytokines and chemokines will be discussed. Furthermore, regulation of immune cells by polyphenols will be illustrated with special reference to the activation of T regulatory cells which support a tolerogenic pathway at intestinal level. Additionally, the effects of red grape polyphenols will be analyzed in obesity, as a low-grade systemic inflammation. Also, possible modifications of inflammatory bowel disease biomarkers and clinical course have been studied upon polyphenol administration, either in animal models or in clinical trials. Moreover, the ability of polyphenols to cross the blood–brain barrier has been exploited to investigate their neuroprotective properties. In cancer, polyphenols seem to exert several beneficial effects, even if conflicting data are reported about their influence on T regulatory cells. Finally, the effects of polyphenols have been evaluated in experimental models of allergy and autoimmune diseases. Conclusively, red grape polyphenols are endowed with a great antioxidant and anti-inflammatory potential but some issues, such as polyphenol bioavailability, activity of metabolites, and interaction with microbiota, deserve deeper studies.

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Neuroprotective benefits of grape seed and skin extract in a mouse model of Parkinson’s disease

Cited by 42 publications

References 61 publications

Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Interaction of Polyphenols as Antioxidant and Anti-Inflammatory Compounds in Brain–Liver–Gut Axis

Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies

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