Neuroprotective and memory-enhancing effects of methanolic leaf extract of Peristrophe bicalyculata in rat model of type 2 diabetes mellitus.

Njan, Anoka A.; Adenuga, Francisca O.; Ajayi, Abayomi Mayowa; Sotunde, Olasubomi F; Ologe, Mary O.; Olaoye, Solomon O.; Erdoğan, Özlem; Iwalewa, Olugbenga

doi:10.1016/j.heliyon.2020.e04011

Cited by 19 publications

(9 citation statements)

References 38 publications

(41 reference statements)

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“…For instance, rats treated with Fibraurea recisa showed anti-neuroinflammatory activity and also anti-amyloidogenic and anti-tau effects [ 74 ]. In another rat model, Peristrophe bicalyculata treatment led to anti-neuroinflammatory activity and reduced cognitive decline [ 163 ].…”

Section: Resultsmentioning

confidence: 99%

Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease

Tyler

2022

Nat. Prod. Bioprospect.

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Alzheimer’s disease (AD) is progressive and ultimately fatal, with current drugs failing to reverse and cure it. This study aimed to find plant species which may provide therapeutic bioactivities targeted to causal agents proposed to be driving AD. A novel toolkit methodology was employed, whereby clinical symptoms were translated into categories recognized in ethnomedicine. These categories were applied to find plant species with therapeutic effects, mined from ethnomedical surveys. Survey locations were mapped to assess how this data is at risk. Bioactivities were found of therapeutic relevance to 15 hypothesised causal bases for AD. 107 species with an ethnological report of memory improvement demonstrated therapeutic activity for all these 15 causal bases. The majority of the surveys were found to reside within biodiversity hotspots (centres of high biodiversity under threat), with loss of traditional knowledge the most common threat. Our findings suggest that the documented plants provide a large resource of AD therapeutic potential. In demonstrating bioactivities targeted to these causal bases, such plants may have the capacity to reduce or reverse AD, with promise as drug leads to target multiple AD hallmarks. However, there is a need to preserve ethnomedical knowledge, and the habitats on which this knowledge depends. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease

Tyler

2022

Nat. Prod. Bioprospect.

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“…As stated by Njan et al [ 17 ], rats’ cognitive performance was examined four weeks following STZ injection using MWM test. A circular tank (180 cm in diameter, 60 cm in height) was filled to a depth of 30 cm with opaque water (22 ± 2°C).…”

Section: Methodsmentioning

confidence: 99%

Neurotherapeutic effects of quercetin-loaded nanoparticles and Biochanin-A extracted from Trifolium alexandrinum on PI3K/Akt/GSK-3β signaling in the cerebral cortex of male diabetic rats

Newairy,

Hamaad,

Wahby

et al. 2024

PLoS ONE

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Diabetes mellitus (DM) is a severe metabolic disease that can have significant consequences for cognitive health. Bioflavonoids such as Trifolium alexandrinum (TA), quercetin (Q), and Biochanin-A (BCA) are known to exert a wide range of pharmacological functions including antihyperglycemic activity. This study aimed to investigate the neurotherapeutic effects of quercetin-loaded nanoparticles (Q-LNP) and BCA extracted from TA against diabetes-induced cerebral cortical damage through modulation of PI3K/Akt/GSK-3β and AMPK signaling pathways. Adult male Wistar albino rats (N = 25) were randomly assigned to one of five groups: control, diabetics fed a high-fat diet (HFD) for 2 weeks and intraperitoneally (i.p.) injected with STZ (40 mg/kg), and diabetics treated with Q-LNP (50 mg/kg BW/day), BCA (10 mg/kg BW/day), or TA extract (200 mg/kg BW/day). Treatments were applied by oral gavage once daily for 35 days. Diabetic rats treated with Q-LNP, BCA, and TA extract showed improvement in cognitive performance, cortical oxidative metabolism, antioxidant parameters, and levels of glucose, insulin, triglyceride, and total cholesterol. In addition, these treatments improved neurochemical levels, including acetylcholine, dopamine, and serotonin levels as well acetylcholinesterase and monoamine oxidase activities. Furthermore, these treatments lowered proinflammatory cytokine production for TNF-α and NF-κB; downregulated the levels of IL-1β, iNOS, APP, and PPAR-γ; and attenuated the expressions of PSEN2, BACE, IR, PI3K, FOXO 1, AKT, AMPK, GSK-3β, and GFAP. The histopathological examinations of the cerebral cortical tissues confirmed the biochemical results. Overall, the present findings suggest the potential therapeutic effects of TA bioflavonoids in modulating diabetes-induced cerebral cortical damage.

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“…Where: ID -discrimination index, Tnew -time spent exploring a new object or an object located in a changed place, Tknown -time spent exploring a known object [41].…”

Section: Pharmacological Assaysmentioning

confidence: 99%

MM165 - A Small Hybrid Molecule Modulates the Kynurenine Pathway and Attenuates Lipopolysaccharide-Induced Memory Deficits and Inflammation

Kotańska,

Łanocha,

Bednarski

et al. 2024

Neurochem Res

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Cognitive dysfunctions are now recognized as core symptoms of various psychiatric disorders e.g., major depressive disorder. Sustained immune activation may leads to cognitive dysfunctions. Proin ammatory cytokines shunt the metabolism of tryptophan towards kynurenine and quinolinic acid may accumulate at toxic concentrations. This acid triggers an increase in neuronal nitric oxide synthase function and promotes oxidative stress. The searching for small molecules that can regulate tryptophan metabolites produced in the kynurenic pathway has become an important goal in developing treatments for various central nervous system diseases with an in ammatory component. Previously we have identi ed a small hybrid molecule -MM165 which signi cantly reduces depressive-like symptoms caused by in ammation induced by lipopolysaccharide administration. In the present study, we investigated whether this compound would mitigate cognitive de cits induced by lipopolysaccharide administration and whether treatment with it would affect the plasma or brain levels of quinolinic acid and kynurenic acid.Neuroin ammation was induced in rats by administering lipopolysaccharide at a dose of 0.5 mg/kg body weight for 10 days. We conducted two tests: novel object recognition and object location, to assess the effect on memory impairment in animals previously treated with lipopolysaccharide. In plasma collected from rats, the concentrations of C-reactive protein and tumor necrosis factor alfa were determined. The concentrations of kynurenic acid and quinolinic acid were determined in plasma and homogenates obtained from the cerebral cortex of rats. Interleukin 6 in the cerebral cortex of rats was determined.Additionally, the body mass and spontaneous activity were measured in rats. Our study shows that MM165 may mitigate cognitive de cits induced by in ammation after administration of lipopolysaccharide and alter the concentrations of tryptophan metabolites in the brain. Compounds exhibiting a mechanism of action analogous to that of MM165 may serve as foundational structures for the development of a new class of antidepressants.

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Neuroprotective and memory-enhancing effects of methanolic leaf extract of Peristrophe bicalyculata in rat model of type 2 diabetes mellitus.

Cited by 19 publications

References 38 publications

Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease

Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease

Neurotherapeutic effects of quercetin-loaded nanoparticles and Biochanin-A extracted from Trifolium alexandrinum on PI3K/Akt/GSK-3β signaling in the cerebral cortex of male diabetic rats

MM165 - A Small Hybrid Molecule Modulates the Kynurenine Pathway and Attenuates Lipopolysaccharide-Induced Memory Deficits and Inflammation

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