Neuroprotective and antioxidant effects of docosahexaenoic acid (DHA) in an experimental model of multiple sclerosis

Muñoz-Jurado, Ana; Escribano, Begoña M.; Galván, Alberto; Valdelvira, Manuel E.; Caballero-Villarraso, Javier; Giraldo, Ana I.; Santamaría, Abel; Luque, Evelio; Agüera, Eduardo; LaTorre, Manuel; Túnez, Isaac

doi:10.1016/j.jnutbio.2023.109497

Cited by 1 publication

(1 citation statement)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple sclerosis (MS) is a chronic inflammatory and neurological disease of the central nervous system (CNS) that its prevalence in women is three times higher than in men indicating which sex-related factors have an effect on an individual’s susceptibility to developing the condition [ 1 , 2 ]. MS occurs when lymphocytes cross the blood-brain barrier (BBB) and initiate axonal demyelinating processes [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Resistance training modifies of serum levels of matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases in multiple sclerosis women - a randomized controlled trail

Nezhad,

Parnow,

Khamoushian

et al. 2024

BMC Neurosci

View full text Add to dashboard Cite

The objectives of the present study was to investigate the effects of resistance training (RT) on serum levels of controlling blood-brain barrier (BBB) permeability indices and cognitive performance in MS women (MS-W). In this randomized control trail study (IRCT registration code: IRCT20120912010824N3, 07.09.2023), twenty-five MS-W were randomly divided into sedentary (MS) and resistance exercise (12 weeks/3 times per week/ 60–80% of 1RM) (MS + RT) groups. Fifteen healthy aged-matched women participated as a control group (HCON). The serum level of matrix metalloproteinase-2 (MMP-2), matrix metallopeptidase-9 (MMP-9), tissue metalloproteinase inhibitors-1 (TIMP-1), tissue metalloproteinase inhibitors-2 (TIMP-2), and S100 calcium-binding protein B (S100B) were assessed. In addition, cognitive performance was assessed pre- and post- intervention with the Brief International Cognitive Assessment for MS (BICAMS). A significant reduction in MMP-2, TIMP-2 serum levels, and MMP-2/TIMP-2 ratio were observed in post-test for MS + RT group (p < 0.01) in comparison to the HCON and MS groups; however, no changes were observed in MMP-9, TIMP-1, S100B and MMP-9/TIMP-1 ratio after RT (p > 0.05). The verbal learning was improved in post-test for MS + RT group (p < 0.01), although no change were observed for visuospatial memory and information processing speed (p > 0.05). These findings suggest that resistance training can modify some indices of BBB permeability and improve verbal learning in MS-W. The findings may also be beneficial as a non-pharmacological intervention to reduce inflammation.

show abstract

Section: Introductionmentioning

confidence: 99%