Neuroprotective Activities of Orientin: A Review

Abstract

: Orientin is a flavonoid C-glycoside found in many plants, and studies investigating its neuropharmacological benefits have received significant attention in recent years. Orientin has modulating effects on various neuropathological pathways such as Nrf2-ARE, PI3K/Akt, JNK-ERK1/2, and TLR4/NF-kB. Orientin, therefore, evaluated for its benefits in various neurodegenerative diseases such as Alzheimer's and Huntington's disease. This paper reviews Orientin's neuroprotective mechanisms and benefits.