Neuroprotective Actions of Flavones and Flavonols: Mechanisms and Relationship to Flavonoid Structural Features

Dajas, Federico; Andres, Abin-Carriquiry Juan; Arredondo, Florencia; Echeverry, Carolina; Felicia, Rivera-Megret

doi:10.2174/18715249112129990012

Cited by 64 publications

(13 citation statements)

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“…The ability of flavonoids to protect neurones from cell death is well documented (Dajas et al, 2013;Devore et al, 2012;Grosso et al, 2013;Jager and Saaby, 2011;Latif, 2015;Spencer, 2008a;Vauzour, 2014). A variety of mechanisms appear to underlie such neuroprotective actions.…”

Section: Flavonoids As Neuroprotectants and Antioxidantsmentioning

confidence: 99%

“…Indeed the heath claims of antioxidant capacity regarding polyphenolcontaining nutraceuticals has be described as 'fiction' (Espin et al, 2007). In a study of structural features of the neuroprotective actions of flavonoids it was concluded that neuroprotection appears to be linked to specific structural motifs beyond those involved in antioxidation (Dajas et al, 2013).…”

Section: Flavonoids As Neuroprotectants and Antioxidantsmentioning

confidence: 99%

“…Some individual flavonoids are used as dietary supplements. There are numerous reviews on flavonoids as nutraceuticals (Georgiev et al, 2014;Jain et al, 2010;Tapas et al, 2008), some highlighting the effects of flavonoids on the central nervous system particularly as neuroprotectants (Dajas et al, 2013;Devore et al, 2012;Grosso et al, 2013;Jager and Saaby, 2011;Latif, 2015;Spencer, 2008a;Vauzour, 2014) and for their effects on memory and cognition (Fruson et al, 2012;Letenneur et al, 2007;Mastroiacovo et al, 2015;Spencer, 2008bSpencer, , 2010.…”

Section: Introductionmentioning

confidence: 99%

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Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA

Johnston

2015

Neurochemistry International

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Section: Flavonoids As Neuroprotectants and Antioxidantsmentioning

confidence: 99%

Section: Flavonoids As Neuroprotectants and Antioxidantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA

Johnston

2015

Neurochemistry International

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“…Others: Reduce inflammatory biomarkers; bacteriostatic against some gut pathogenic bacteria; food colorants [205,208,213,214]. Alzheimer's disease [220][221][222].…”

Section: Chlorogenic Acidmentioning

confidence: 99%

Engineering of Microbial Cell Factories for the Production of Plant Polyphenols with Health-Beneficial Properties

Dudnik

Gaspar

Neves

et al. 2018

CPD

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Polyphenols form a group of important natural bioactive compounds with numerous ascribed healthbeneficial attributes (e.g. antioxidant, anti-inflammatory, anti-microbial and tumor-suppressing properties). Some polyphenols can also be used as natural dyes or plastic precursors. Notwithstanding their relevance, production of most of these compounds still relies on extraction from plant material, which for most of it is a costly and an inefficient procedure. The use of microbial cell factories for this purpose is an emerging alternative that could allow a more efficient and sustainable production. The most recent advances in molecular biology and genetic engineering, combined with the ever-growing understanding of microbial physiology have led to multiple success stories. Production of multiple polyphenolic compounds or their direct precursors has been achieved not only in the common production hosts, such as Escherichia coli and Saccharomyces cerevisiae, but also in Corynebacterium glutamicum and Lactococcus lactis. However, boosting production of native compounds or introduction of heterologous biosynthetic pathways also brings certain challenges, such as the need to express, balance and maintain efficient precursor supply. This review will discuss the most recent advances in the field of metabolic engineering of microorganisms for polyphenol biosynthesis and its future perspectives, as well as outlines their potential health benefits and current production methods.

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“…Flavonoids have been considered to be the most potent nutraceuticals because of their widespread beneficial effects for human health by a broad spectrum of mechanisms of action that are widely discussed . Recent research has also shown that some flavonoids may exert their beneficial effects associated with modulation of mitochondrial biogenesis, mitochondrial dynamic oxidative respiration and ATP anabolism and mitochondrial redox status via modulation of mitochondrial function, such as quercetin, epigallocatechin gallate (EGCG), baicalein, and baicalin . In addition, a recent review article has highlighted that flavonoids improve endothelial or adipocyte functions via the mitochondria .…”

Section: Chemoprevention Potential Of Dietary Natural Compounds: Targmentioning

confidence: 99%

Chemoprevention of obesity by dietary natural compounds targeting mitochondrial regulation

Lai

et al. 2016

Molecular Nutrition Food Res

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Mitochondria are at the center stage in the control of energy homeostasis in many organs and tissues including adipose tissue. Recently, abundant evidence from experimental studies has clearly supported the strong correlation between mitochondrial dysfunction in adipocytes and obesity. Various physiological conditions such as excessive nutrition, genetic factors, hypoxia, and toxins disrupt mitochondrial function by impairing mitochondrial biogenesis, dynamics, and oxidative capacity. Mitochondrial dysfunction in adipocytes could have an impact on differentiation, adipogenesis, insulin sensitivity, and the significant alteration in their metabolic function, which ultimately results in obesity and type 2 diabetes. Numerous dietary natural compounds are the subject of research for the prevention and treatment of obesity through reprogramming multiple metabolic pathways. Some of them have the potential against obesity by modulating insulin signaling, decreasing oxidative damage, downregulating adipokines secretion, and increasing mitochondrial DNA that improves mitochondrial function and thus maintain metabolic homeostasis. Here, we focus on and summarize and briefly discuss the currently known targets and the mitochondria-targeting effects of dietary natural compounds in the intervention of obesity.

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Neuroprotective Actions of Flavones and Flavonols: Mechanisms and Relationship to Flavonoid Structural Features

Cited by 64 publications

References 0 publications

Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA

Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA

Engineering of Microbial Cell Factories for the Production of Plant Polyphenols with Health-Beneficial Properties

Chemoprevention of obesity by dietary natural compounds targeting mitochondrial regulation

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