Neuroprotective action of melatonin on neonatal rat motoneurons after sciatic nerve transection

Rogério, Fábio; Queiróz, Luciano de Souza; Teixeira, Simone Aparecida; Oliveira, Alexandre Leite Rodrigues de; Nucci, Gilberto De; Langone, Francesco

doi:10.1016/s0006-8993(02)02710-5

Cited by 16 publications

(28 citation statements)

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“…[30][31][32] A possible protective effect of MLT as an antioxidant agent and an inhibitor of neuronal NOS (nNOS) was investigated on spinal motoneurons after axonal injury. 33 It was found in this experiment that nNOS might not be involved in neuronal death or survival. 33 Other authors have reported conflicting results concerning the effects of MLT on nNOS activity.…”

Section: Free Radical Scavenging Effects Of Melatonin In Peripheral Nmentioning

confidence: 67%

“…33 It was found in this experiment that nNOS might not be involved in neuronal death or survival. 33 Other authors have reported conflicting results concerning the effects of MLT on nNOS activity. [34][35][36] Apoptotic events after sciatic axotomy and after administration of MLT were investigated experimentally in the spinal cords of neonatal rats.…”

Section: Free Radical Scavenging Effects Of Melatonin In Peripheral Nmentioning

confidence: 67%

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Untitled

2017

J Brachial Plex Peripher Nerve Inj

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Section: Free Radical Scavenging Effects Of Melatonin In Peripheral Nmentioning

confidence: 67%

Section: Free Radical Scavenging Effects Of Melatonin In Peripheral Nmentioning

confidence: 67%

Untitled

2017

J Brachial Plex Peripher Nerve Inj

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“…Melatonin is able to reduce not only apoptotic cell death in the central nervous system [38] but also the death of rat motoneurons induced by sciatic nerve transection in neonatal rats [44]. Rogerio et al [44] reported a significant decrease in motor neuron death in the neonatal spinal cord after administration of results for nerve repair are usually disappointing, and functional recovery is often suboptimal after peripheral nerve injury.…”

Section: Effect Of Melatonin Treatment On Apoptosis and Neuronal Cellmentioning

confidence: 99%

“…Rogerio et al [44] reported a significant decrease in motor neuron death in the neonatal spinal cord after administration of results for nerve repair are usually disappointing, and functional recovery is often suboptimal after peripheral nerve injury. Scar formation is a challenge for peripheral nerve surgeon.…”

Section: Effect Of Melatonin Treatment On Apoptosis and Neuronal Cellmentioning

confidence: 99%

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Melatonin and its therapeutic actions on peripheral nerve regeneration

Kandemir

Sarıkcıoğlu

2015

Folia Morphol

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Neonatal exposure to antiepileptic drugs disrupts striatal synaptic development

Forcelli

Janssen

Vicini

et al. 2012

Annals of Neurology

124

113

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Objective Drug exposure during critical periods of brain development may adversely affect nervous system function, posing a challenge for treating of infants. This is of particular concern for treating neonatal seizures, as early-life exposure to drugs such as phenobarbital is associated with adverse neurological outcomes in patients and induction of neuronal apoptosis in animal models. The functional significance of the preclinical neurotoxicity has been questioned due to the absence of evidence for functional impairment associated with drug-induced developmental apoptosis. Method We used patch-clamp recordings to examine functional synaptic maturation in striatal medium spiny neurons (MSNs) from neonatal rats exposed to antiepileptic drugs with proapoptotic action (phenobarbital, phenytoin, lamotrigine) and without proapoptotic action (levetiracetam). Phenobarbital-exposed rats were also assessed for reversal learning at weaning. Result Recordings from control animals revealed increased inhibitory and excitatory synaptic connectivity between postnatal day (P)10 and 18. This maturation was absent in rats exposed at P7 to a single dose of phenobarbital, phenytoin, or lamotrigine. Additionally, phenobarbital exposure impaired striatal-mediated behavior on P25. Neuroprotective pretreatment with melatonin, which prevents drug-induced neurodevelopmental apoptosis, prevented the drug-induced disruption in maturation. Levetiracetam was found not to disrupt synaptic development. Interpretation Our results provide the first evidence that exposure to antiepileptic drugs during a sensitive postnatal period impairs physiological maturation of synapses in neurons that survive the initial drug insult. These findings suggest a mechanism by which early-life exposure to AEDs can impact cognitive and behavioral outcomes, underscoring the need to identify therapies that control seizures without compromising synaptic maturation.

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Neuroprotective action of melatonin on neonatal rat motoneurons after sciatic nerve transection

Cited by 16 publications

References 0 publications

Untitled

Untitled

Melatonin and its therapeutic actions on peripheral nerve regeneration

Neonatal exposure to antiepileptic drugs disrupts striatal synaptic development

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