Neuroprotection, Photoperiod, and Sleep

Martínez-Vargas, Marina; Porras-Villalobos, Mercedes Graciela; Estrada-Rojo, Francisco; Martínez‐Tapia, Ricardo Jesús; Pérez-Arredondo, Adán; Barajas-Martínez, Antonio; Navarro, Luz

doi:10.5772/intechopen.85013

Cited by 1 publication

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“…In the case of TBI, it is clear that the time of occurrence of this event depends on the activities of the subjects. However, recognizing that there is a differential response depending on the time of occurrence and identifying the systems involved in this response, will provide a novel approach to treat TBI ( Martinez-Vargas et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Diurnal Variation Induces Neurobehavioral and Neuropathological Differences in a Rat Model of Traumatic Brain Injury

et al. 2020

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Traumatic brain injury (TBI) induces two types of brain damage: primary and secondary. Damage initiates a series of pathophysiological processes, such as metabolic crisis, excitotoxicity with oxidative stress-induced damage, and neuroinflammation. The long-term perpetuation of these processes has deleterious consequences for neuronal function. However, it remains to be elucidated further whether physiological variation in the brain microenvironment, depending on diurnal variations, influences the damage, and consequently, exerts a neuroprotective effect. Here, we established an experimental rat model of TBI and evaluated the effects of TBI induced at two different time points of the light–dark cycle. Behavioral responses were assessed using a 21-point neurobehavioral scale and the cylinder test. Morphological damage was assessed in different regions of the central nervous system. We found that rats that experienced a TBI during the dark hours had better behavioral performance than those injured during the light hours. Differences in behavioral performance correlated with less morphological damage in the perilesional zone. Moreover, certain brain areas (CA1 and dentate gyrus subregions of the hippocampus) were less prone to damage in rats that experienced a TBI during the dark hours. Our results suggest that diurnal variation is a crucial determinant of TBI outcome, and the hour of the day at which an injury occurs should be considered for future research.

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Section: Discussionmentioning

confidence: 99%