Neuroprotection Is Technology, Not Science

DeGracia, Donald J.; Taha, Doaa; Anggraini, Fika Tri; Huang, Zhifeng

doi:10.1007/978-3-319-45345-3_3

Cited by 1 publication

(4 citation statements)

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“…However, the original form of the theory possessed limitations as detailed in Ref. [ 5 ]. This led us to reformulate the theory, which was introduced elsewhere [ 5 ] but for which we here provide a deeper analysis.…”

Section: Introductionmentioning

confidence: 99%

“…[ 5 ]. This led us to reformulate the theory, which was introduced elsewhere [ 5 ] but for which we here provide a deeper analysis. Technically, the original theory consisted of a system of autonomous nonlinear ordinary differential equations.…”

Section: Introductionmentioning

confidence: 99%

“…We have developed the refined theory elsewhere [ 5 ] and therefore give only a brief summary here. We begin with our idealized picture of acute cell injury: there is a cell which is acutely injured with intensity I .…”

Section: Introductionmentioning

confidence: 99%

“…In addition to the assumption embodied by Equation (1) we now assume that (a) the velocity parameter decreases exponentially with time (Equation (3)), and (b) the decay parameter is a function of the instantaneous difference of D and S (Equation (4)). The rationalization of these assumptions was discussed previously [ 5 ].

…”

Section: Introductionmentioning

confidence: 99%

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Abstraction and Idealization in Biomedicine: The Nonautonomous Theory of Acute Cell Injury

et al. 2018

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Neuroprotection seeks to halt cell death after brain ischemia and has been shown to be possible in laboratory studies. However, neuroprotection has not been successfully translated into clinical practice, despite voluminous research and controlled clinical trials. We suggested these failures may be due, at least in part, to the lack of a general theory of cell injury to guide research into specific injuries. The nonlinear dynamical theory of acute cell injury was introduced to ameliorate this situation. Here we present a revised nonautonomous nonlinear theory of acute cell injury and show how to interpret its solutions in terms of acute biomedical injuries. The theory solutions demonstrate the complexity of possible outcomes following an idealized acute injury and indicate that a “one size fits all” therapy is unlikely to be successful. This conclusion is offset by the fact that the theory can (1) determine if a cell has the possibility to survive given a specific acute injury, and (2) calculate the degree of therapy needed to cause survival. To appreciate these conclusions, it is necessary to idealize and abstract complex physical systems to identify the fundamental mechanism governing the injury dynamics. The path of abstraction and idealization in biomedical research opens the possibility for medical treatments that may achieve engineering levels of precision.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

…”

Section: Introductionmentioning

confidence: 99%

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