Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid

Packer, Lester; Tritschler, Hans; Wessel, Klaus

doi:10.1016/s0891-5849(96)00269-9

Cited by 595 publications

(362 citation statements)

References 155 publications

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“…a-Lipoic acid is an antioxidant, which penetrates cell membrane and can act intracellularly (Bierhaus et al, 1997). Neuroprotective properties of the substance, e.g., a decrease of the effect of neurotoxins, have been demonstrated in cell culture systems Packer et al, 1997). a-Lipoic acid increases glucose metabolism, e.g.…”

Section: Discussionmentioning

confidence: 99%

Alpha-lipoic acid as a new treatment option for Azheimer type dementia

Häger¹,

Marahrens²,

Kenklies³

et al. 2001

Archives of Gerontology and Geriatrics

166

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Oxidative stress and energy depletion are characteristic biochemical hallmarks of Alzheimer's disease (AD), thus antioxidants with positive effects on glucose metabolism such as thioctic (a-lipoic) acid should exert positive effects in these patients. Therefore, 600 mg a-lipoic acid was given daily to nine patients with AD and related dementias (receiving a standard treatment with acetylcholinesterase inhibitors) in an open study over an observation period of, on avarage, 337 980 days. The treatment led to a stabilization of cognitive functions in the study group, demonstrated by constant scores in two neuropsychological tests (mini-mental state examination: MMSE and AD assessment scale, cognitive subscale: ADAScog). Despite the fact that this study was small and not randomized, this is the first indication that treatment with a-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.

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Section: Discussionmentioning

confidence: 99%

Alpha-lipoic acid as a new treatment option for Azheimer type dementia

Häger¹,

Marahrens²,

Kenklies³

et al. 2001

Archives of Gerontology and Geriatrics

166

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“…2). Thus, antioxidant effects of ALA or its derivates occur both in the hydrophilic phase and in the hydrophobic membrane portion [18][19][20]. Lipoic acid is synthesized in the body in very small amounts and is covalently bound to the E2 enzyme subunit of the four different alpha-keto acid dehydrogenase complexes in mitochondria.…”

Section: Alpha-lipoic Acid (Lipoate)mentioning

confidence: 99%

Therapeutic perspectives on the combination of α-lipoic acid and vitamin E

González-Pérez

González-Castañeda

2006

Nutrition Research

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Alpha-lipoic acid and vitamin E have synergistic effects, as determined in models of oxidant radical lesions. This review summarizes recent findings showing that the combination of alpha-lipoic acid plus vitamin E has beneficial effects in reducing oxidative damage in ischemic or other oxidationrelated pathological events. Both antioxidants are common in the normal human diet and side effects are very rare. Therefore, alpha-lipoic acid and vitamin E can counteract oxidative processes and could have an important role in clinical medicine.

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“…NAC, the precursor molecule of GSH, cannot cross the BBB after exogenous administration (Gilgun-Sherki et al, 2002). On the other hand, a-lipoic acid that is readily absorbed from the diet does cross the BBB (Packer et al, 1997).…”

Section: Cns Bioavailability Of Dietary Antioxidants and Pufasmentioning

confidence: 99%