Neuroprotection by Minocycline Caused by Direct and Specific Scavenging of Peroxynitrite

Targeting the Overproduction of Peroxynitrite for the Prevention and Reversal of Paclitaxel-Induced Neuropathic Pain

“…Notably, minocycline, a nonselective inhibitor of both microglia (Tikka et al, 2001) and astrocytes (Raghavendra et al, 2003) activation, attenuates paclitaxelinduced mechanical hypersensitivity and downregulation of both GLAST and GLT-1 in spinal cord (Zhang et al, 2012). However, it is possible that the beneficial effects of minocycline are mediated through its antioxidant (Kraus et al, 2005) and potent PN scavenging (Schildknecht et al, 2011) properties. Our findings revealed that glial cells may be important for at least two PNdependent mechanisms in spinal cord.…”

Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model

“…High levels of nitric oxide production via inducible nitric oxide synthase (iNOS) are related to dilated cardiomyopathy and congestive heart failure [23] . Radical interaction of nitric oxide with superoxide will produce another highly toxic oxidant, peroxynitrite anion (ONOO-), which can interact with nucleic acids [24] .…”

Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases

“…Under these conditions, progressive degeneration of neurites and ultimately cell death can be observed. Differentiated lUHMeS cells are electrically active and express functional dopamine transporter (DAT), vesicular monoamine transporter (VMAT-2), and the PD-related protein alpha-synuclein (ASYN) (Schildknecht et al, 2009(Schildknecht et al, , 2011Scholz et al, 2011). In the brain, ASYN accounts for about 1% of total protein mass.…”